Plataforma de Información Curricular

Lineas de investigación

Códigos sinápticos y epigenéticos de la memoria en el envejecimiento y en la Enfermedad de Alzheimer
Dimorfismo sexual en los códigos moleculares que controlan la actividad neuronal
Neurobiología traslacional: evaluación de fármacos con potencial terapéutico para el deterioro cognitivo usando sinapsis aisladas de cerebros humanos postmortem

Publicaciones recientes

1. McQuade A., Kang Y., Hasselmann J., Jairaman A., Sotelo A., Coburn M., Shabestari S.K., Chadarevian J.P., Fote G., Tu C.H., Danhash E., Silva J., Martinez E., Cotman C., Prieto G.A., Thomson L.M., Steffan J.S., Smith I., Davtyan H., Cahalan M., Cho H., Blurton-Jones M., Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease, Nature Communications, noviembre de 2020; 11(1), 5370

2. Rodriguez-Ortiz C.J., Prieto G.A., Martini A.C., Forner S., Trujillo-Estrada L., LaFerla F.M., Baglietto D., Cotman C.W., Kitazawa M., miR-181a inhibition rescues synaptic plasticity and memory in models of Alzheimer’s disease, Aging cell, noviembre de 2020; 19(3), e13118

3. Berchtold N.C., Prieto G.A., Phelan P., Gillen D.L., Baldi P., Bennett D.A. Buchman A.S. and Cotman C.W., Hippocampal gene expression patterns linked to late-life physical activity in humans oppose age and AD-related transcriptional decline, Neurobiol Aging, noviembre de 2019; 78, 142-154

4. Forner S., Martini A.C., Prieto G.A., Dang C.T., Trujillo-Estrada L., da Cunha C., Andrews E.J., Phan J., Vu J., Levites Y., Cruz P.E., Ager R., Medeiros R., Cotman C.W., Golde T., Baglietto-Vargas D., LaFerla F.M. , Intra- and extracellular amyloid-β overexpression via AAV-mediated gene transfer impairs memory and synaptic plasticity in the hippocampus, Scientific Reports, noviembre de 2019; 9, 15936

5. Prieto G.A.*, Smith E.D., Tong L., Nguyen M., Cotman C.W., Inhibition of LTP-induced translation by IL-1β reduces the level of newly synthesized proteins in hippocampal dendrites, ACS Chemical Neuroscience, noviembre de 2019; 10(3), 1197-1203.

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Publicaciones

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1. McQuade A., Kang Y., Hasselmann J., Jairaman A., Sotelo A., Coburn M., Shabestari S.K., Chadarevian J.P., Fote G., Tu C.H., Danhash E., Silva J., Martinez E., Cotman C., Prieto G.A., Thomson L.M., Steffan J.S., Smith I., Davtyan H., Cahalan M., Cho H., Blurton-Jones M., Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease, Nature Communications, noviembre de 2020; 11(1), 5370

2. Rodriguez-Ortiz C.J., Prieto G.A., Martini A.C., Forner S., Trujillo-Estrada L., LaFerla F.M., Baglietto D., Cotman C.W., Kitazawa M., miR-181a inhibition rescues synaptic plasticity and memory in models of Alzheimer’s disease, Aging cell, noviembre de 2020; 19(3), e13118

3. Berchtold N.C., Prieto G.A., Phelan P., Gillen D.L., Baldi P., Bennett D.A. Buchman A.S. and Cotman C.W., Hippocampal gene expression patterns linked to late-life physical activity in humans oppose age and AD-related transcriptional decline, Neurobiol Aging, noviembre de 2019; 78, 142-154

4. Forner S., Martini A.C., Prieto G.A., Dang C.T., Trujillo-Estrada L., da Cunha C., Andrews E.J., Phan J., Vu J., Levites Y., Cruz P.E., Ager R., Medeiros R., Cotman C.W., Golde T., Baglietto-Vargas D., LaFerla F.M. , Intra- and extracellular amyloid-β overexpression via AAV-mediated gene transfer impairs memory and synaptic plasticity in the hippocampus, Scientific Reports, noviembre de 2019; 9, 15936

5. Prieto G.A.*, Smith E.D., Tong L., Nguyen M., Cotman C.W., Inhibition of LTP-induced translation by IL-1β reduces the level of newly synthesized proteins in hippocampal dendrites, ACS Chemical Neuroscience, noviembre de 2019; 10(3), 1197-1203.

6. Trujillo-Estrada L., Nguyen C., Cunha C., Cai L., Forner S., Martini A.C., Ager R.R., Prieto G.A., Cotman C.W., Baglietto-Vargas D., LaFerla F.M., Tau underlies synaptic and cognitive deficits for type 1, but not type 2 diabetes mouse models, Aging cell, noviembre de 2019; 18(3), e12919

7. Belloso-Iguerategui A., Zamarbide M., Merino-Galan L., Rodríguez-Chinchilla T., Gago B., Santamaria E., Fernández-Irigoyen J., Cotman C.W., Prieto G.A., Quiroga-Varela A., Rodríguez-Oroz M.C. , Hippocampal synaptic failure is an early event in experimental parkinsonism with subtle cognitive deficit, Brain, diciembre de 2023; 146(12), 4949–4963

8. Lautrup S., Holst C.M., Yde A., Asmussen S., Larsen K., Richner M., Vægter C.B., Prieto G.A., Berchtold N.C., Cotman C.W., Stevnsner T. , The role of aging and BDNF signalling in expression of base excision repair genes in the human brain, Aging cell, septiembre de 2023; 22(9), e13905

9. Prieto G.A.*, Cotman C.W. , Early bioenergetic and autophagy impairments at the Parkinson’s disease synapse, Brain, junio de 2022; 145(6), 1877-1879

10. Prieto G.A.*, Tong L., Smith E.D., Cotman C.W., TNFα and IL-1β but not IL-18 suppresses hippocampal long-term potentiation directly at the synapse, Neurochemical Research, noviembre de 2019; 44(1), 49-60

11. Baglietto D., Prieto G.A., Limon A., Forner S., Rodriguez-Ortiz C.J., Ikemura K., Ager R.R., Medeiros R., Trujillo-Estrada L., Martini A.C., Kitazawa M, Davila J.C., Cotman C.W., Gutierrez A., LaFerla F.M., AMPA signaling and actin cytoskeleton impairments underlie early synaptic dysfunction in a mouse model of Alzheimer’s disease, Aging cell, agosto de 2018; 17(4), e12791

12. Tong L., Prieto G.A., Cotman C.W., IL-1β suppresses cLTP-induced surface expression of GluA1 and actin polymerization via ceramide-mediated Src activation, Journal Of Neuroinflammation, abril de 2018; 15(1), 127

13. Prieto G.A.*, Cotman C.W., On the road towards the global analysis of human synapses, Neural Regeneration Research, octubre de 2017; 12(10), 1586-1589

14. Prieto G.A.* , Abnormalities of dopamine D3 receptor signaling in the diseased brain, J Cent Nerv Syst Dis, agosto de 2017; 9, 1179573517726335

15. Prieto G.A.*, Cotman C.W., Cytokines and cytokine networks target neurons to modulate long-term potentiation, Cytokine & Growth Factor Rev, abril de 2017; 34, 27-33

16. Carlos, A.J., Tong L., Prieto G.A., and Cotman C.W., IL-1b impairs retrograde flow of BDNF signaling by attenuating endosome trafficking, Journal Of Neuroinflammation, febrero de 2017; 14(1), 29

17. Prieto G.A.*, Trieu B.H., Dang C.T., Bilousova T., Gylys K.H., Berchtold N.C., Lynch G. and Cotman C.W., Pharmacological rescue of long-term potentiation in Alzheimer diseased synapses, Journal Of Neuroscience, febrero de 2017; 1(37), 1197-1212

18. Snigdha S., Prieto G.A., Kirakosian A., Loertscher B.M., Dieskau A.P., Overman L.E., Cotman C.W., H3K9me3 Inhibition Improves Memory, Promotes Spine Formation, and Increases BDNF Levels in the Aged Hippocampus, Journal Of Neuroscience, diciembre de 2016; 36(12), 3611-22

19. Prieto G.A.*, Snigdha S., Baglietto-Vargas D., Smith E.D., Berchtold N.C., Tong L., Ajami D., LaFerla F.M., Rebek Jr. J*. and Cotman C.W.*, Synapse-specific IL-1 receptor subunit reconfiguration augments vulnerability to IL-1 in the aged hippocampus, Proc Natl Acad Sci USA, septiembre de 2015; 112(36), E5078-87

20. Hernández-Flores T., Hernández-González O., Pérez-Ramírez M.B., Lara-González E., Arias-García M.A., Duhne M., Perez-Burgos A., Prieto G.A., Figueroa A., Galarraga E., Bargas J., Modulation of direct pathway striatal projection neurons by muscarinic M4–type receptors, Neuropharmacology, febrero de 2015; 89, 232-244

21. Hernández-González O., Hernández-Flores T., Prieto G.A., Perez-Burgos A., Arias-Garcia M.A., Galarraga E., Bargas J, Modulation of Ca2+ currents by sequential and simultaneous activation of adenosine A1 and A2A receptors in striatal projection neurons, Purinergic Signalling, septiembre de 2014; 10(2), 269-281

22. Smith E.D., Prieto G.A., Tong L., Sears-Kraxberger I., Rice J.D., Steward O., Cotman C.W., Rapamycin and Interleukin-1b impair Brain-Derived Neurotrophic Factor–dependent neuron survival by modulating autophagy, Journal Of Biological Chemistry, julio de 2014; 289(30), 20615-20629

23. Snigdha S., Smith E.D., Prieto G.A., Cotman C.W., Caspase-3 activation as a bifurcation point between plasticity and cell death, Neurosci Bull, diciembre de 2012; 28(1), 14-24

24. Tong L., Prieto G.A., Kramar E., Smith E.D., Cribbs D., Lynch G., Cotman C.W., BDNF-dependent synaptic plasticity is suppressed by IL-1b via p38 MAPK, Journal Of Neuroscience, diciembre de 2012; 32(49), 17714 –17724

25. Prieto G.A., Perez-Burgos A., Palomero-Rivero M., Galarraga E., Drucker-Colin R., Bargas J., Up-regulation of D2-class signaling in dopamine-denervated striatum is in part mediated by D3 receptors acting on CaV2.1 channels via PIP2 depletion, Journal Of Neurophysiology, mayo de 2011; 105(5), 2260-2274

26. Prieto G.A., Progression of endometriosis to cancer: too MUCh FoxP3+ regulatory T cells response?, Disease Models & Mechanisms, marzo de 2011; 4(2), 139-140

27. Perez-Burgos A., Prieto G.A., Galarraga E., Bargas J., CaV2.1 is modulated by muscarinic M1 receptors through phosphoinositides hydrolysis in neostriatal neurons, Neuroscience, enero de 2010; 165(2), 293-299

28. Prieto G.A., Perez-Burgos A., Fiordelisio T., Salgado H., Galarraga E., Drucker-Colin R., Bargas J., Dopamine D2-class receptor supersensitivity as reflected in Ca2+ current modulation in neostriatal neurons, Neuroscience, diciembre de 2009; 164(4), 345-350

29. Perez-Burgos A., Perez-Rosello T., Salgado H., Flores E., Prieto G.A., Figueroa A., Galarraga E., Bargas J., Muscarinic M1 modulation of N and L types currents is mediated by protein kinase C in neostriatal neurons, Neuroscience, septiembre de 2008; 155(4), 1079-1097

30. Prieto G.A. & Rosenstein Y., Oestradiol potentiates the suppressive function of human CD4+CD25+ regulatory T cells by promoting their proliferation, Immunology, mayo de 2006; 118, 58-65

31. Prieto G.A., Cabral A.R., Zapata-Zuñiga M., Simón A.J., Villa A.R., Alarcón-Segovia D. and Cabiedes J., Valine/Valine genotype at the position 247 of the 2-glicoprotein-I gene in Mexican patients with primary anti-phospholipid syndrome. Association with anti-2-glycoprotein-I antibodies, Arthritis Rheumatism, febrero de 2003; 48(2), 471-474

32. Prieto G.A., Cabral A.R., Cabiedes J., b2-Glycoprotein-I polymorphism. Its role in antiphospholipid syndrome, Revista Española de Reumatología, diciembre de 2002; 29(8), 396-404

33. Prieto G.A., Villamar-Cruz O., Saqui-Salces M., Neri-Gómez T., Almaraz-Nieves A., Hernández-Molina V.I., Valdez-Rodríguez H., Camacho-Arroyo I., How do steroid hormones work?, Educacion Quimica, diciembre de 2002; 14(4), 196-201

Ultimas tesis dirigidas

1. ARISBETH CITLALI VALENCIA MORALES (estudiante), Análisis del marcador epigenético H3K9me3 en neuronas de hipocampo dorsal en ratones expuestos a un ambiente novedoso, Modalidad: Tesis, NEUROCIENCIAS, Licenciatura, INB, Instituto de Neurobiología UNAM-Juriquilla, Fecha de presentación de examen: 26/05/2023, Prieto Moreno G. Aleph (Director)

2. Citlali Anahí Suárez Rangel (estudiante), PAPEL DEL MARCADOR EPIGENÉTICO H3K9me3 EN LA ACTIVACIÓN DE LAS NEURONAS DEL GIRO DENTADO , Modalidad: Tesis, Química Farmacéutico Biológica, Licenciatura, Facultad de Química, Universidad Autónoma de Queretaro, Fecha de presentación de examen: 29/07/2022, Prieto Moreno G. Aleph (Director)

3. JOSÉ ALBERTO BONILLA TORRES (estudiante), Diseño e implementación de un método para el estudio simultáneo de marcadores sinápticos y epigenéticos en el hipocampo , Modalidad: Tesis, Ing. en Biotecnología, Licenciatura, UTC, Universidad Tecnológica de Corregidora, Fecha de presentación de examen: 30/07/2021, Prieto Moreno G. Aleph (Director)

Capítulos en libros recientes

1. Prieto G.A. & Rosenstein Y, P. Joseph-Bravo , Molecular Endocrinology, 1, 1, , India, enero de 2006