Plataforma de Información Curricular

Research Interest

Thyroid hormones and their role in the development of the central nervous system. New approaches to study the molecular mechanisms mediated by their nuclear receptors.

Most Recent Publications

1. Lazcano I.*, Pech-Pool SM., Maldonado-Lira MF., Olvera A., Darras VM., Orozco A., Ontogeny of Thyroid Hormone Signaling in the Retina of Zebrafish: Effects of Thyroidal Status on Retinal Morphology, Cell Survival, and Color Preference., International Journal in Molecular Sciences, November 2024; 25(22), 12215

2. Lazcano I., Pech-Pool S.M.*, Olvera A.*, García-Martínez I., Palacios-Pérez S., Orozco A.* , The importance of thyroid hormone signaling during early development: Lessons from the zebrafish model. , General and Comparative Endocrinology, April 2023; General and Comparative Endocrinology 334: 114225.(334), 114225

3. Farías-Serratos BM., Lazcano I., Villalobos P. and Orozco A*., Thyroid hormone deficiency during zebrafish development impairs CNS myelination. , Plos One, August 2021

4. Lazcano I., Cisneros A., Concha L., Ortíz J., Garza E, Orozco A. , MRI- and histologically-derived neuroanatomical atlas of the Ambystoma mexicanum (axolotl)., Scientific Reports, May 2021; 11(9850)

5. Hernández-Linares Y., Olvera A., Villalobos P. Lozano-Flores C., Varela-Echavarría A., Luna M., Orozco A. , 3,5-T2 and 3,3′,5-T3 Regulate Cerebellar Thyroid Hormone Signalling and Myelin Molecular Dynamics in Tilapia. , Scientific Reports, April 2019; 9(7359)

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Publicaciones

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1. Lazcano I.*, Pech-Pool SM., Maldonado-Lira MF., Olvera A., Darras VM., Orozco A., Ontogeny of Thyroid Hormone Signaling in the Retina of Zebrafish: Effects of Thyroidal Status on Retinal Morphology, Cell Survival, and Color Preference., International Journal in Molecular Sciences, November 2024; 25(22), 12215

2. Lazcano I., Pech-Pool S.M.*, Olvera A.*, García-Martínez I., Palacios-Pérez S., Orozco A.* , The importance of thyroid hormone signaling during early development: Lessons from the zebrafish model. , General and Comparative Endocrinology, April 2023; General and Comparative Endocrinology 334: 114225.(334), 114225

3. Farías-Serratos BM., Lazcano I., Villalobos P. and Orozco A*., Thyroid hormone deficiency during zebrafish development impairs CNS myelination. , Plos One, August 2021

4. Lazcano I., Cisneros A., Concha L., Ortíz J., Garza E, Orozco A. , MRI- and histologically-derived neuroanatomical atlas of the Ambystoma mexicanum (axolotl)., Scientific Reports, May 2021; 11(9850)

5. Hernández-Linares Y., Olvera A., Villalobos P. Lozano-Flores C., Varela-Echavarría A., Luna M., Orozco A. , 3,5-T2 and 3,3′,5-T3 Regulate Cerebellar Thyroid Hormone Signalling and Myelin Molecular Dynamics in Tilapia. , Scientific Reports, April 2019; 9(7359)

6. Lazcano I, Hernández-Puga G, Robles JP, Orozco A. , Alternative Ligands for Thyroid Hormone Receptors., Mol Cell Endocrinol , April 2019; 493(110048)

7. Lazcano I., Rodríguez-Ortiz R., Villalobos P., Martínez-Torres A., Solís-Saínz J.C., Orozco A., Knock-down of specific thyroid hormone receptor isoforms impairs body plan development in zebrafish. , Frontiers in Endocrinology, January 2019; 10(156)

8. Lazcano I. Orozco A., Revisiting Available Knowledge on Teleostean Thyroid Hormone Receptors., General And Comparative Endocrinology, January 2018; 265(128), 132

9. Olvera A, Martyniuk C. J., Buisine N., Jiménez-Jacinto V., Sanchez-Flores A., Sachs L.M., Orozco A*., Differential transcriptome regulation by 3,5-T2 and 3,3,5-T3 in brain and liver uncovers novel roles for thyroid hormones in tilapia., Scientific Reports, December 2017; 7, 15043

10. Hernández-Puga G., Mendoza A., León-del-Río A., Orozco A, Jab1 is a T2-dependent coactivator or a T3-dependent corepressor of TRB1-mediated gene regulation., J Endocrinol, January 2017; 232, 1-9

11. Hernández-Puga G., Navarrete-Ramírez P., Olvera A. Mendoza A., Villalobos, P., Orozco A. , 3,5-diiodothyronine-mediated transrepression of the thyroid hormone receptor beta gene in tilapia. insights on cross-talk between the thyroid hormone and cortisol signaling pathways. , Molecular And Cellular Endocrinology, April 2016; 425, 103-110

12. Olvera A., Mendoza A., Villalobos P., Mayorga-Martínez P., Orozco A.*, Valverde-R. C., The variable region of iodothyronine deiodinases directs their catalytic properties and subcellular localization., Molecular And Cellular Endocrinology, January 2015; 402, 107-112

13. Orozco A., Navarrete-R, P., Olvera A., García-G, C. , 3,5-Diiodothyronine (T2) is on a Role. A New Hormone in the Search of Recognition., General And Comparative Endocrinology, July 2014; 203, 174-180

14. Navarrete-Ramírez P., Luna M., Valverde-R C., Orozco A., 3,5-T2 Participates in Tilapia Growth through a Different Isoform of Thyroid Hormone Receptor β1., Journal Of Molecular Endocrinology, February 2014; 52, 1-9

15. Ávila-Mendoza J., Urban-Sosa VA., Lazcano I., Orozco A., Luna M. Martínez-Moreno CG., Arámburo C. , Comparative analysis of Krüppel-like factors expression in the retinas of zebrafish and mice during development and after injury., General and Comparative Endocrinology, July 2024

16. Lazcano I., Olvera A., Pech-Pool S., Sach L., Buisine N. and Orozco A.* , Differential effects of 3,5-diiodo-L-thyronine and 3,3',5-L-triiodothyronine on the gill regeneration and metamorphosis of the Ambystoma mexicanum (axolotl). , Frontieres in Endocrinology (Lausanne), July 2023; 14, 1208182

17. Reyes-Bravo DY., Villalobos-Aguilera P., Almonte-Zepeda J.T., Mendoza-Trejo MS., Giordano M., Orozco A., Rodríguez V.M. , Chronic atrazine exposure increases the expression of genes associated with GABAergic and glutamatergic systems in the brain of male albino rat., Frontiers in Toxicology, August 2022

18. Lazcano I., Rodríguez Rodríguez A., Uribe R.M., Orozco A., Joseph-Bravo P. and Charli J-L., Evolution of thyrotropin-releasing factor extracellular communication units., General And Comparative Endocrinology, October 2020

19. Orozco A*., Hernández-Puga G., Lazcano I., Olvera A. , Non-mammalian models reveal the role of alternative ligands for thyroid hormone receptors., Mol Cell Endocrinol , December 2017; 459(59), 63

20. Ávila-Mendoza J., Carranza M, Villalobos P., Olvera A., Orozco A., Luna M., Aramburo C. , Differential responses of the somatotropic and thyroid axes to environmental temperature changes in the green iguana., General And Comparative Endocrinology, April 2016; 230-231, 76-86

21. Mendoza A., Navarrete-Ramírez P., Hernández-Puga G., Villalobos P., Holzer G., Renaud J.P., Laudet V., Orozco A., 3,5-T2 is an Alternative Ligand for the Thyroid Hormone Receptor β1., Endocrinology, August 2013; 154, 2948-2958

22. Orozco A., Valverde-R C., Olvera A. García-G C. , Iodothyronine Deiodinases. An Evolutionary and Functional Perspective., J Endocrinol, September 2012; 215, 207–219

23. Navarrete Ramírez P., Orozco A., Olvera A., Valverde-R C., Toledo Cuevas M., Ross. L.G., Martínez-Palacios C.A. , Effects of the administration of micro doses of thyroxine (T4) on the growth and survival of pike silverside (Chirostoma estor) juveniles. , Aquaculture Research, May 2011; 42, 808-814

24. Solis-S J.C., Orozco A., García-G C., Robles L., Valverde-R C., Bioactividad de las hormonas tiroideas. Importancia clínica de los transportadores de membrana, de las desyodasas y de los receptores nucleares. Revisión, Revista de Investigacion Clinica, May 2011; 63(3), 284-305

25. Valverde-R.,C. y Orozco, A. , Sin hormonas no hay neuronas, y menos si las que faltan son las tiroideas, Revista Digital Universitaria, March 2011; 12(3), xxx-xxx online

26. Solis-S. J.C., Villalobos P., Orozco A., Delgado G, Quintanar-Stephano A, García-Solís P, Hernández-Montiel H, Robles-Osorio L and Valverde-R C. , Inhibition of intrathyroidal dehalogenation by iodine., J Endocrinol, January 2011; 208, 89-96

27. Villalobos P., Orozco A., and Valverde-R. C. , Hepatic iodothyronine deiodinase type 3 in the snake Pituophis deppei: Biochemical and molecular characterization, General And Comparative Endocrinology, 2010; 169(2), 167-173

28. Mayorga M.L., Orozco A., Villalobos P., and Valverde-R. C. , Cloning and Characterization of a Type 3 Iodothyronine Deiodinase (D3) in the Liver of the Chondrichtyan Chiloscyllium punctatum., General And Comparative Endocrinology, March 2008; 156(1), 464-469 online

29. López-Bojorquez L, Villalobos P., García-G C., Orozco A., and Valverde-R C. , Functional identification of an osmotic response element (ORE) in the promoter region of deiodinase 2 (FhDio2) in the killifish. , Journal Of Experimental Biology, 2007; 210, 3126-3132

30. García-G. C., López-Bojórquez L., Nuñez J., Valverde-R.C., Orozco A., 3,5- diiodothyronine (3,5-T2) in vivo maintains euthyroidal hepatic expression of type 2 iodothyronine deiodinase, growth hormone and thyroid hormone receptor β1 in the killifish., American Journal Of Physiology-Cell Physiology, May 2007; 293(0), 877-883 online

31. Orozco A., Valverde-R.C., Thyroid hormone deiodination in fish. Review, Thyroid, January 2005; 15(8), 799-813 online

32. García-G. C., Jeziorski M.C., Valverde-R C., and Orozco A., Effects of iodothyronines on the hepatic thyroid hormone activating pathway in killifish., General And Comparative Endocrinology, 2004; 135, 201-209

33. Solis-Sainz, J.C., Villalobos, P., Orozco A., and Valverde-R, C, Biochemical Characterization and Comparison of Rat Thyroid Iodotyrosine Dehalogenase and Iodothyronine Deiodinase Type 1., Journal Of Endocrinology, 2004; 181(3), 385-392

34. Valverde-R, C., Orozco, A., Becerra, A., Jeziorski M.C., Villalobos, P., and Solis-S, J.C, Halometabolites and cellular dehalogenase systems. An evolutionary perspective. Review, International Review of Cytology, 2004; 234, 143 – 199

35. Orozco A., Fenton B., and Valverde-R C, Temporal profile of the outer- and inner-ring iodothyronine deiodinase pathways in the liver and skin of the rainbow trout, Oncorhynchus mykiss., Fish Physiology And Biochemistry, 2003; 29(4), 297-303

36. Orozco A., Villalobos P., Jeziorski M.C., and Valverde-R C., The liver of Fundulus heteroclitus expresses deiodinase type 1 mRNA., General And Comparative Endocrinology, 2003; 130(1), 84-91

37. Orozco A., Villalobos P., Valverde-R C, Environmental salinity selectively modifies the outer-ring deiodinating activity of liver and kidney in the rainbow trout., Comparative Biochemistry And Physiology A-Molecular & Integrative Physiology, 2002; 131(2), 387-395

38. Orozco A, Jeziorski MC, Linser PJ, Greenberg RM, Valverde-R C, Characterization of the gene and complete cDNA encoding a type II deiodinase from Fundulus heteroclitus, General And Comparative Endocrinology, January 2002; 128(0), 162-167

39. Orozco A., Linser P.J., Valverde-R.C., Kinetic characterization of outer-ring deiodinase activity (ORD) in the liver, gill and retina of Fundulus heteroclitus., Comparative Biochemistry And Physiology B-Biochemistry & Molecular Biology, January 2000; 126(0), 283-290

40. Orozco A., Linser, P.J., and Valverde-R C. , Salinity modifies hepatic outer ring deiodinating (ORD) activity in Fundulus heteroclitus. , Annals of the New York Academy of Sciences. Trends in Comparative Endocrinology and Neurobiology, 1998; 839(13), 409-411

41. Fenton B., Orozco A. y Valverde-R C. , Kinetic characterization of skin inner-ring deiodinase pathways and its correlation with circulating levels of reverse T3 (rT3) in developing rainbow trout. , Endocrinology, January 1997; 154(3), 547-554

42. Orozco A., Silva J. E., Valverde-R.C., Rainbow trout liver expresses two iodothyronine phenolic deiodinase pathways with the characteristics of mammalian types I and II 5'deiodinases., Endocrinology, January 1997; 138(0), 254-258

43. Valverde-R.C., Croteau W., LaFleur. G. J.Jr., Orozco A., Germain D.L., Cloning and expression of a 5'-iodothyronine deiodinase from the liver of Fundulus heteroclitus., Endocrinology, January 1997; 138(0), 642-648

44. Orozco A., Ruíz Juvera A. y Valverde-R.C. , The importance of employing homologous serum free of thyronines in radioimmunoassays to assess circulating thyroid hormones in rainbow trout., Bol. Estud. Med. Biol. Méx, January 1992; 14(4), 41-49

Most Recent Advised Theses

1. María Guadalupe GarcíA Martínez (estudiante), Efectos del tratamiento con vinclozolin (VZ) durante la embriogénesis en la formación de mielina de los oligodendrocitos y en la conducta asociada a la mielinización en el pez cebra (Danio rerio)., Modalidad: Por proyecto de investigación, Maestría en Ciencias en Neurometabolismo. , Maestría, Universidad Autónoma de Querétaro, Universidad Autónoma de Querétaro, Fecha de presentación de examen: 2024-04-30, Orozco Rivas Aurea (Director)

2. Brenda Minerva Farías Serratos (estudiante), La deficiencia de hormonas tiroideas durante el desarrollo del sistema nervioso central afecta la mielinización en el pez cebra., Modalidad: Tesis, Doctorado en Ciencias Biomédicas, Doctorado, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Fecha de presentación de examen: 2022-08-31, Orozco Rivas Aurea (Director)

3. Samuel Palacios Pérez (estudiante), Identificación de receptores de hormonas tiroideas y su participación en el proceso de mielinización en el desarrollo del sistema nervioso central., Modalidad: Tesis, Licenciatura en Ingeniería Bioquímica, Licenciatura, Universidad Tecnológica de Corregidora, Universidad Tecnológica de Corregidora., Fecha de presentación de examen: 2022-05-27, Orozco Rivas Aurea (Director)

4. Rolando López Avalos (estudiante), La participación del binomio T3-thraa en los procesos de mielinización temprana del pez cebra., Modalidad: Tesis, Licenciatura en Químico Farmacéutico Biotecnólogo, Licenciatura, Universidad del Valle de México, Universidad del Valle de México, Fecha de presentación de examen: 2021-11-26, Orozco Rivas Aurea (Director)

5. Guadalupe Yasmín Hernández Linares (estudiante), T3 y T2 regulan diferencialmente la expresión de genes asociados a la función tiroidea en el cerebelo de tilapia., Modalidad: Tesis, Doctorado en Ciencias Biomédicas, Doctorado, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Fecha de presentación de examen: 2021-05-05, Orozco Rivas Aurea (Director)