Plataforma de Información Curricular

Research Interest

Assessment of contrast sensitivity as a method of prediction and monitoring of early diabetic neuroretinopathy
Characterization of slow intrinsic oscillations in the retina under physiological conditions and models of obesity and diabetes: focus on voltage-dependent channels and TRPV4
Exploration of intrinsic retinal oscillations as a marker of neurodegenerative damage and functional recovery in response to treatment.
Usin of slow intrinsic retinal oscillations for screening for early diabetic neuroretinopathy, risk factors for type 2 diabetes, open-angle glaucoma, and mental disorders like depression

Most Recent Publications

1. Noguez Imm R, Muñoz-Benitez J, Medina D, Barcenas E, Molero-Castillo G, Reyes-Ortega P, Hughes-Cano JA, Medrano-Gracia L, Miranda-Anaya M, Rojas-Piloni G, Quiroz-Mercado H, Hernández-Zimbrón LF, Fajardo-Cruz ED, Ferreyra-Severo E, García-Franco R, Rubio Mijangos JF, López-Star E, García-Roa M, Lansingh VC, and Thébault SC , Preventable risk factors for type 2 diabetes can be detected using noninvasive spontaneous electroretinogram signals, Plos One, January 2023; 1(18)

2. Ramsés Noguez Imm, Julio Muñoz-Benitez, Diego Medina, Everardo Barcenas, Guillermo Molero-Castillo, Pamela Reyes-Ortega, Jorge Armando Hughes-Cano, Leticia Medrano-Gracia, Manuel Miranda-Anaya, Gerardo Rojas-Piloni, Hugo Quiroz-Mercado, Luis Fernando Hernández-Zimbrón, Elisa Denisse Fajardo-Cruz, Ezequiel Ferreyra-Severo, Renata García-Franco, Ellery López-Star, Marlon García-Roa, Van Charles Lansingh, Stéphanie C. Thébault, Spontaneous electroretinogram signals to screen people with early risk factors for diabetic retinopathy, MedRxiv, November 2022

3. Stéphanie Thébault, Minireview: Insights into the role of TRP channels in the retinal circulation and function, Neuroscience Letters, November 2020; 765(136285)

4. Edith Arnold*, Stéphanie Thébault*, Rodrigo M. Aroña*(*co-autoria), Gonzalo Martínez de la Escalera, Carmen Clapp, Prolactin mitigates deficiencies of retinal function associated with aging, Neurobiology of Aging, October 2019; 85, 38-48

5. Orduña Ríos M, Noguez Imm R, Hernández Godínez N, Bautista Cortes AM, Liedtke W, Martínez-Torres A, Concha L, Thebault S , TRPV4 inhibition prevents increased water diffusion and blood-retina barrier breakdown in the retinal of streptozotocin-induced diabetic mice, Plos One, May 2019; 14(5), e0212158

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Publicaciones

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1. Noguez Imm R, Muñoz-Benitez J, Medina D, Barcenas E, Molero-Castillo G, Reyes-Ortega P, Hughes-Cano JA, Medrano-Gracia L, Miranda-Anaya M, Rojas-Piloni G, Quiroz-Mercado H, Hernández-Zimbrón LF, Fajardo-Cruz ED, Ferreyra-Severo E, García-Franco R, Rubio Mijangos JF, López-Star E, García-Roa M, Lansingh VC, and Thébault SC , Preventable risk factors for type 2 diabetes can be detected using noninvasive spontaneous electroretinogram signals, Plos One, January 2023; 1(18)

2. Ramsés Noguez Imm, Julio Muñoz-Benitez, Diego Medina, Everardo Barcenas, Guillermo Molero-Castillo, Pamela Reyes-Ortega, Jorge Armando Hughes-Cano, Leticia Medrano-Gracia, Manuel Miranda-Anaya, Gerardo Rojas-Piloni, Hugo Quiroz-Mercado, Luis Fernando Hernández-Zimbrón, Elisa Denisse Fajardo-Cruz, Ezequiel Ferreyra-Severo, Renata García-Franco, Ellery López-Star, Marlon García-Roa, Van Charles Lansingh, Stéphanie C. Thébault, Spontaneous electroretinogram signals to screen people with early risk factors for diabetic retinopathy, MedRxiv, November 2022

3. Stéphanie Thébault, Minireview: Insights into the role of TRP channels in the retinal circulation and function, Neuroscience Letters, November 2020; 765(136285)

4. Edith Arnold*, Stéphanie Thébault*, Rodrigo M. Aroña*(*co-autoria), Gonzalo Martínez de la Escalera, Carmen Clapp, Prolactin mitigates deficiencies of retinal function associated with aging, Neurobiology of Aging, October 2019; 85, 38-48

5. Orduña Ríos M, Noguez Imm R, Hernández Godínez N, Bautista Cortes AM, Liedtke W, Martínez-Torres A, Concha L, Thebault S , TRPV4 inhibition prevents increased water diffusion and blood-retina barrier breakdown in the retinal of streptozotocin-induced diabetic mice, Plos One, May 2019; 14(5), e0212158

6. Arredondo Zamarripa D*, Noguez Imm R* (*co-autoria), Bautista Cortés AM, Vázquez Ruíz O, Bernardini M, Fiorio Pla A, Gkika D, Prevarskaya N, López-Casillas F, Liedtke W, Clapp C, and Thebault S , Dual contribution of TRPV4 antagonism in the regulatory effect of vasoinhibins on blood-retinal barrier permeability: diabetic milieu makes a difference. , Scientific Reports, October 2017; 7(1), 13094

7. Thebault S, Potential mechanisms behind the antioxidant actions of prolactin in the retina, Experimental Eye Research, July 2017; 160, 56-61

8. Meléndez García R*, Arredondo Zamarripa R*, Arnold E* (*, equal contribution), Ruiz-Herrera X, Noguez Imm R, Baeza Cruz G, Adán N, Binart N, Riesgo-Escovar N, Goffin V, Ordaz B, Peña-Ortega F, Martínez-Torres A, Clapp C, and Thebault S, Prolactin protects retinal pigment epithelium by inhibiting SIRT2-dependent cell death, EBioMedicine, April 2016; 7, 35-49

9. Arredondo Zamarripa D, Díaz-Lezama N, Meléndez García R, Clapp C, and Thebault S (autor de correspondencia), Vasoinhibins regulate the inner and outer blood-retinal barrier and limit retinal oxidative stress, Frontiers in Cellular Neuroscience, October 2014; 8(333)

10. Arnold E*, Thebault S* (*co-autoria; autor de correspondencia), Baeza-Cruz G, Arredondo Zamarripa D, Adán N, Quintanar-Stéphano A, Condés-Lara M, Rojas-Piloni G, Binart N, Martínez de la Escalera G, and Clapp C., The hormone prolactin is a novel, endogenous trophic factor able to regulate reactive glia and to limit retinal degeneration., Journal Of Neuroscience, June 2014; 34(5), 1868-78

11. Thebault S, El epitelio pigmentario retiniano como componente de la barrera hematoretiniana: implicación en la retinopatía diabética, Revista Digital Universitaria, June 2011; 12(3), 00-10 online

12. Clapp C, Thebault S, Jeziorski MC, and Martínez de la Escalera G. , Peptide hormone regulation of angiogenesis, Physiological Reviews, June 2009; 89(4), 1177-215

13. García, C., Aranda, J., Arnold, E., Thebault, S., Macotela, J., López-Casillas, F., Mendoza, V., Quiroz-Mercado, H., Lin, S.H., Martínez de la Escalera, G., Clapp, C., Vasoinhibins prevent increased retinal vasopermeability associated with diabetic retinopathy via protein phosphatase 2A-dependent eNOS inactivation, Journal Of Clinical Investigation, June 2008; 118(6), 2291-2300

14. Rivera, J.C., Aranda, J., Riesgo, J., Nava, G., Thebault, S., López-Barrera, F., Ramírez, M., Martínez de la Escalera, G., Clapp, C, Expression and cellular localization of prolactin and the prolactin receptor in mammalian retina., Experimental Eye Research, June 2008; 86(2), 314-321

15. Tiel Groenestege WM, Thebault S, van den Berg D, Janssen R, Tejpar S, van den Heuvel LP, van Cutsem E, Hoenderop JG, Knoers NV and Bindels RJ, Impaired basolateral sorting of pro-EGF causes isolated recessive renal hypomagnesemia, Journal Of Clinical Investigation, June 2007; 117(8), 2260-2267

16. Thebault S, Flourakis M, Vanoverberghe K, Vandermoere F, Roudbaraki M, Lehen´kyi V, Slomianny C, Beck B, Mariot P, Bonnal JL, Mauroy B, Shuba Y, Capiod T, Skryma R, Prevarskaya N., Differential role of transient receptor potential channels in Ca2+ entry and proliferation of prostate cancer epithelial cells, Cancer Research, June 2006; 66(4), 2038-2047

17. Thebault S (autor de correspondencia), Zholos A, Enfissi A, Slomianny C, Dewailly E, Roudbaraki M, Parys J, Prevarskaya N., Receptor-operated Ca2+ entry mediated by TRPC3/TRPC6 proteins in rat prostate smooth muscle (PS1) cell line, Journal Of Cellular Physiology, June 2005; 204(1), 320-328

18. Thebault S, Lemonnier L, Bidaux G, Flourakis M, Bavencoffe A, Gordienko D, Roudbaraki M, Delcourt P, Panchin Y, Shuba Y, Skryma R, Prevarskaya N., Novel role of cold/menthol-sensitive transient receptor potential melastatine family member 8 (TRPM8) in the activation of store-operated channels in LNCaP human prostate cancer epithelial cells., Journal Of Biological Chemistry, June 2005; 280(47), 39423-39435

19. Thebault S, Roudbaraki M, Sydorenko V, Shuba Y, Lemonnier L, Slomianny C, Dewailly E, Bonnal JL, Mauroy B, Skryma R, Prevarskaya N., Alpha1-adrenergic receptors activate Ca(2+)-permeable cationic channels in prostate cancer epithelial cells, Journal Of Clinical Investigation, June 2003; 111(11), 1691-1701

20. Rodríguez-Arzate CA, Noguez-Imm R, Reyes-Ortega P, Rodríguez-Ortiz LR, García-Peña MF, Ordaz RP, Vélez-Uriza F, Cisneros-Mejorado A, Arellano RO, Perez CI, Hernández-Zimbrón LF, Hughes-Cano JA, Quiroz-Mercado H, García-Franco R, Rubio Mijangos JF, López-Star E, García-Roa E, Lansingh VC, Dégardin J, Simonutti M, Picaud D, and Thébault SC, Potential contributions of the intrinsic retinal oscillation recording using non-invasive electroretinogram to bioelectronics., Frontiers in Cellular Neuroscience, December 2023

21. Hughes-Cano JA, Quiroz-Mercado H, Hernández-Zimbrón LF, García-Franco R, Rubio Mijangos JF, López-Star E, García-Roa M, Lansingh VC, Olivares-Pinto U, Thébault SC, Improved predictive diagnosis of diabetic macular edema based on hybrid models: an observational study, Computers in Biology and Medicine, March 2023; 170

22. Gonzalez-Gonzalez MA, Conde SV, Latorre R, Thébault SC, Pratelli M, Spitzer NC, Verkhratsky A, Tremblay ME, Akcora CG, Hernandez-Reynoso AG, Ecker M, Coates J, Vincent KL, Ma B, Bioelectronic medicine: a multidisciplinary roadmap from biophysics to precision therapies, Frontiers in Integrative Neuroscience, February 2023

23. Pamela Reyes-Ortega, Alejandra Rodríguez-Arzate, Ramsés Noguez-Imm, Edith Arnold, and Stéphanie C. Thébault, Contribution of chemical and electrical transmission to the low delta-like intrinsic retinal oscillation in mice: a role for day-light activated neuromodulators , European Journal Of Pharmacology, February 2023

24. JA Hughes-Cano, H Quiroz-Mercado, LF Hernández-Zimbrón, R García-Franco, JF Rubio Mijangos, E López-Star, M García-Roa, VC Lansingh, U Olivares-Pinto, Thebault SC. , Improved predictive diagnosis of diabetic macular edema based on hybrid models: an observational study, MedRxiv, January 2023

25. Lázaro-Guevara J.M., Flores- Robles B-J, Garrido-Lopez K.M., Labrador-Sánchez E., Pinillos-Aransay V., Trasahedo E.A., López-Martín J-A., Tellez-Arreola J.L., Thebault SC (corresponding author), Identification of RP1 as the genetic cause of retinitis pigmentosa in a multi-generational pedigree using Extremely Low-Coverage Whole Genome Sequencing (XLC-WGS), GENE, January 2023

26. Benítez-Angeles M., Juárez-González E., Vergara-Jaque A., Llorente I., Rangel-Yescas G., Thébault S.C. Hiriart M., Islas L.D., Rosenbaum T. , Unconventional interactions of the TRPV4 ion channel with beta-adrenergic receptor ligands, Life Science Alliance, December 2022

27. Thebault S, Pérdida de visión por diabetes: detección y tratamiento, Revista Digital Universitaria, May 2019; 20(3)

28. Thebault S, Una luz frente a la pérdida de visión por diabetes, Revista Digital Universitaria, September 2018; 19(5)

29. David Arredondo Zamarripa, Ramsés Noguez Imm, Dulce María Soría Lara, Alessandra Fiorio Pla, Dimitra Gkika, Natalia Prevarskaya, Ataúlfo Martínez-Torres, Wolfang Liedtke, Carmen Clapp, and Stéphanie Thebault., Dual contribution of TRPV4 antagonism in the regulatory effect of vasoinhibins on blood-retinal barrier permeability: diabetic milieu makes a difference., Scientific Reports, December 2017; 7(1), 13094

30. Thebault S, Potential mechanisms behind the antioxidant actions of prolactin in the retina, Experimental Eye Research, December 2017; (160), 56-61

31. Zamorano M, Ledesma-Colunga MG, Adán N, Vera-Massieu C, Lemini M, Méndez I, Moreno-Carranza B, Neumann ID, Thebault S, Martínez de la Escalera G, Torner L, and Clapp C. , Prolactin-derived vasoinhibins increase anxiety- and depression-related behaviors., Psychoneuroendocrinology, June 2014; 44, 123-32

32. García, C., Nuñez-Arita, R.E., Thebault, S. (autor de correspondencia), Arredondo-Zamarripa, D., Jeziorski, M.C., Martínez de la Escalera, G., Clapp, C. , Requirement of phosphorytable endothelial nitric oxide synthase at Ser-1177 for vasoinhibin-mediated antiangiogenic effects, Endocrine, March 2014; 45(2), 263-270

33. Adan N, Guzman-Morales J, Ledesma-Colunga G, Perales-Canales SI, Quintanar-Stephano A, Lopez-Barrera F, Mendez I, Moreno-Carranza B, Triebel J, Binart N, Martínez de la Escalera G, Thebault S, and Clapp C, Prolactin promotes cartilage survival and attenuates inflammation in rheumatoid arthritis., Journal Of Clinical Investigation, September 2013; 123(9), 3902-13

34. Vanoverberghe K*, Lehen'kyi V*, Thébault S* (*, de igual contribución), Raphaël M, Vanden Abeele F, Slomianny C, Mariot P, Prevarskaya N., Cytoskeleton reorganization as an alternative mechanism of store-operated calcium entry control in neuroendocrine-differentiated cells, Plos One, December 2012; 9(9), e45615

35. Thebault S* (autor de correspondencia), González C* (*, de igual contribución), García C, Arredondo Zamarripa D, Nava G, Vaca L, López-Casillas F, Martinez de la Escalera G, Clapp C., Vasoinhibins Prevent Bradykinin-Stimulated Endothelial Cell Proliferation by Inactivating eNOS via Reduction of both Intracellular Ca2+ Levels and eNOS Phosphorylation at Ser1179., Pharmaceuticals, December 2011; (4), 1052-1069

36. Vega C, Moreno-Carranza B, Zamorano M, Quintanar-Stephano A, Méndez I, Thebault S, Martinez de la Escalera G, Clapp C., Prolactin promotes oxytocin and vasopressin release by activating neuronal nitric oxide synthase in the supraoptic and paraventricular nuclei., AMERICAN JOURNAL OF PHYSIOLOGY: Regulatory, Integrative and Comparative Physiology, October 2010; 299(6), R1701-8

37. Arnold E, Rivera JC, Thebault S, Moreno-Páramo D, Quiroz-Mercado H, Quintanar-Stéphano A, Binart N, de la Escalera GM, Clapp C, High levels of serum prolactin protect against diabetic retinopathy by increasing ocular vasoinhibins. , Diabetes, August 2010; 59(12), 3192-7

38. Castilla A, García C, Cruz-Soto M, Martínez de la Escalera G, Thebault S (autor de correspondencia), and Clapp C. , Prolactin in ovarian follicular fluid stimulates endothelial cell proliferation., Journal of Vascular Research, December 2009; 47(1), 45-53

39. Cruz-Soto ME, Cosío G, Jeziorski MC, Vargas-Barroso V, Aguilar MB, Cárabez A, Berger P, Saftig P, Arnold E, Thebault S, Martínez de la Escalera G, and Clapp C. , Cathepsin D is the primary protease for the generation of adenohypophyseal vasoinhibins: Cleavage occurs within the prolactin secretory granules., Endocrinology, December 2009; 150(12), 5446-54

40. Thebault S, Alexander RT, Tiel Groenestege WM, Hoenderop JG, Bindels RJ., EGF increases TRPM6 activity and surface expression, Journal of the American Society of Nephrology, January 2009; 20(1), 78-85

41. Cao G*, Thébault S* (*, de igual contribución), van der Wijst J, van der Kemp A, Lasonder E, Bindels RJ, Hoenderop JG., RACK1 Inhibits TRPM6 Activity via Phosphorylation of the Fused alpha-Kinase Domain, Current Biology, December 2008; 18(3), 168-176

42. Clapp C, Thebault S, Arnold E, García C, Rivera JC, Martínez de la Escalera G., Vasoinhibins: Novel inhibitors of ocular angiogenesis, American Journal Of Physiology, Endocrinology And Metabolism, October 2008; 295(4), 772-778

43. Thébault S, Cao G, Venselaar H, Xi Q, Bindels RJ, Hoenderop JG., Role of the alpha-kinase domain in TRPM6 channel and regulation by intracellular ATP, Journal Of Biological Chemistry, May 2008; 283(29), 19999-20007

44. Clapp, C., Thebault, S, Martínez de la Escalera, G., Role of prolactin and vasoinhibins in the regulation of vascular function in mammary gland., Journal Of Mammary Gland Biology And Neoplasia, March 2008; 13(1), 55-67

45. Clapp C., Thebault S., Martínez de la Escalera G., Hormones and postpartum cardiomyopathy, Trends In Endocrinology And Metabolism, November 2007; 18(9), 329-330

46. Bidaux G, Flourakis M, Thebault S, Zholos A, Beck B, Roudbaraki M, Bonnal JL, Mauroy B, Shuba Y, Skryma R and Prevarskaya N, . Differentation status of prostate cells determines TRPM8 channel subcellular localization and function: involvement in carcinogenesis, Journal Of Clinical Investigation, June 2007; 117(6), 1647-1657

47. Topala CN, Tiel-Groenestege W, Thebault S, van den Berg D, Nilius B, Hoenderop JGJ, Bindels R., Molecular determinants of permeation through the cation channel TRPM6, Cell Calcium, June 2007; 41(6), 513-523

48. Beck B, Bidaux G, Bavencoffe A, Lemonnier L, Thebault S, Shuba Y, Barrit G, Skryma R, Prevarskaya N., Prospects for prostate cancer imaging and therapy using high-affinity TRPM8 activators, Cell Calcium, March 2007; 41(3), 285-294

49. Prevarskaya N, Flourakis M, Bidaux G, Thebault S, Skryma R., Differential role of TRP channels in prostate cancer, Biochemical Society Transactions, February 2007; 35(1), 133-135

50. Vanden Abeele F, Zholos A, Bidaux G, Shuba Y, Thebault S, Beck B, Flourakis M, Panchin Y, Skryma R, Prevarskaya N., iPLA2-dependent gating of TRPM8 by lysophospholipids., Journal Of Biological Chemistry, December 2006; 281(52), 40174-40182

51. Gkika D, Topala CN, Chang Q, Picard N, Thebault S, Houillier P, Hoenderop JG and Bindels RJM., Tissue kallikrein stimulates Ca2+ reabsorption via PKC-dependent plasma membrane accumulation of TRPV5, Embo Journal, October 2006; 25(20), 4707-4716

52. Thebault S, Hoenderop JG, Bindels RJ, Epithelial Ca2+ and Mg2+ channels in kidney disease, Advances In Chronic Kidney Disease, April 2006; 13(2), 110-117

53. Bidaux G, Roudbaraki M, Merle C, Crepin A, Delcourt P, Slomianny C, Thebault S, Bonnal JL, Benahmed M, Cabon F, Mauroy B, Prevarskaya N., Evidence for specific TRPM8 expression in human prostate secretory epithelial cells: functional androgen receptor requirement, Endocrine-Related Cancer, June 2005; 12(2), 367-382

54. Lemonnier L, Lazarenko R, Shuba Y, Thebault S, Roudbaraki M, Lepage G, Prevarskaya N, Skryma R., Alterations in the regulatory volume decrease (RVD) and swelling-activated Cl- current associated with neuroendocrine differentiation of prostate cancer epithelial cells, Endocrine-Related Cancer, June 2005; 12(2), 335-349

55. Vanden Abeele F, Lemonnier L, Thebault S, Lepage G, Parys JB, Shuba Y, Skryma R, Prevarskaya N., Two types of store-operated Ca2+ channels with different activation modes and molecular origin in LNCaP human prostate cancer epithelial cells, Journal Of Biological Chemistry, July 2004; 279(29), 30326-30337

56. Sydorenko V, Shuba Y, Thebault S, Roudbaraki M, Lepage G, Prevarskaya N, Skryma R., Receptor-coupled, DAG-gated Ca2+-permeable cationic channels in LNCaP human prostate cancer epithelial cells, Journal Of Physiology-London, May 2003; 548(3), 823-836

Most Recent Advised Theses

1. Jorge Armando Hughes (estudiante), Cambios en las oscilaciones basales del electrorretinograma y en imágenes de tomografía de coherencia óptica y fondo de ojo como método de predicción del edema macular diabético, Modalidad: Obtención de grado, Maestría en Ciencias (Neurobiología), Maestría, UNAM, Instituto de Neurobiologia, Fecha de presentación de examen: 2023-11-14, Thebault - Stéphanie, Colette (Director)

2. Ramsés Noguez Imm (estudiante), Caracterización de la actividad espontánea en retina de ratón y análisis de la contribución del canal TRPV4 en esa actividad en el contexto de la diabetes, Modalidad: Obtención de grado, Doctorado en Ciencias Biomédicas, Doctorado, Instituto de Neurobiología UNAM-Juriquilla, Instituto de Neurobiología UNAM-Juriquilla, Fecha de presentación de examen: 2022-12-13, Thebault - Stéphanie, Colette (Director)

3. Laura Alejandra Montoya Medina (estudiante), Contribución de la glia y de los canales iónicos en la actividad neural intrínseca de la retina en ratón: implicación en un modelo de prediabetes por dieta alta en grasa, Modalidad: Tesis, INGENIERÍA BIOQUÍMICA, Licenciatura, Instituto Tecnológico de Celaya, Instituto Tecnológico Nacional, Fecha de presentación de examen: 2022-06-02, Thebault - Stéphanie, Colette (Director)

4. Marlene Araujo Meza (estudiante), Implementación de la técnica de electrorretinograma ex vivo en explantes retinianos de ratón Mus musculus, Modalidad: Tesis, Ingeniero Bioquímico, Licenciatura, Tecnológico Nacional de México en Celaya, Instituto Tecnológico Nacional, Fecha de presentación de examen: 2019-10-11, Thebault - Stéphanie, Colette (Director)

5. Ana María Bautista Cortés (estudiante), Análisis de la expresión del canal de cloruro activado por calcio TMEM16B en el epitelio pigmentario retiniano en ratones diabéticos por estreptozotocina., Modalidad: Otra modalidad, de Ingeniería en Biotecnología en la Universidad Politécnica de Pachuca , Licenciatura, Universidad Politécnica de Pachuca, Universidad Politécnica de Pachuca, Fecha de presentación de examen: 2018-04-06, Thebault - Stéphanie, Colette (Director)