Plataforma de Información Curricular

Lineas de investigación

Neurofisiología del procesamiento temporal en el rango de los cientos de los milisegundos.
Neurophysiology of temporal processing in primates

Publicaciones recientes

1. Honing, H., Bouwer, FL., Prado, L., and Merchant, H. , Rhesus monkeys (Macaca mulatta) sense isochrony in rhythm, but not the beat. Additional support for the gradual audiomotor evolution hypothesis. , Frontiers in Neuroscience, agosto de 2018; 12(475), 1-15

2. Merchant H.,* and Menon RS. , Editorial Focus on: Invariant and heritable local cortical organization as revealed by fMRI. , Journal Of Neurophysiology, agosto de 2018; 120(1), 758-759

3. Gamez J., Yc, K., Ayala, Y., Prado, L. and Merchant, H*, Predictive and flexible rhythmic tapping in the non-human primate, Annals Of The New York Academy Of Science, mayo de 2018, 30-49.

4. Perez, O. and Merchant, H, The synaptic properties of cells define the hallmarks of interval timing in a recurrent neural network, Journal Of Neuroscience, abril de 2018; 38(17), 4186-4199

5. Mendoza, G., Mendez, J.C., Perez, O. Prado, L., and Merchant, H, Neural basis for categorical boundaries in the primate pre-SMA during relative categorization of time intervals. , Nature Communications, marzo de 2018; 9(1), 1098

...mas

Publicaciones

...menos

1. Honing, H., Bouwer, FL., Prado, L., and Merchant, H. , Rhesus monkeys (Macaca mulatta) sense isochrony in rhythm, but not the beat. Additional support for the gradual audiomotor evolution hypothesis. , Frontiers in Neuroscience, agosto de 2018; 12(475), 1-15

2. Merchant H.,* and Menon RS. , Editorial Focus on: Invariant and heritable local cortical organization as revealed by fMRI. , Journal Of Neurophysiology, agosto de 2018; 120(1), 758-759

3. Gamez J., Yc, K., Ayala, Y., Prado, L. and Merchant, H*, Predictive and flexible rhythmic tapping in the non-human primate, Annals Of The New York Academy Of Science, mayo de 2018, 30-49.

4. Perez, O. and Merchant, H, The synaptic properties of cells define the hallmarks of interval timing in a recurrent neural network, Journal Of Neuroscience, abril de 2018; 38(17), 4186-4199

5. Mendoza, G., Mendez, J.C., Perez, O. Prado, L., and Merchant, H, Neural basis for categorical boundaries in the primate pre-SMA during relative categorization of time intervals. , Nature Communications, marzo de 2018; 9(1), 1098

6. Ayala YA, Lehmann A, and Merchant, H, Monkeys share with humans the neurophysiological basis for encoding sound periodicities captured by the frequency-following response., Scientific Reports, diciembre de 2017; 7(16687)

7. Mendez, J.C., Rocchi, L., Rothwell, J., Jahanshahi, J. and Merchant, H*. , Probing the timing network: a continuous theta burst stimulation study of temporal categorization. , Neuroscience, mayo de 2017; 356(1), 167-175

8. Merchant H.,* and Averbeck BB. , The computational and neural basis of rhythmic timing in medial premotor cortex., Journal Of Neuroscience, abril de 2017; 37(17), 4552-4564

9. Merchant H.,* and Bartolo, R. , Primate beta oscillations and rhythmic behaviors, Journal Of Neural Transmission, marzo de 2017; 124(5), 20-31

10. Gupta D.S., and Merchant H.*, Editorial: Understanding the role of the time dimension in the brain information processing., Frontiers in Psychology , febrero de 2017; 8(240), 1-4

11. García-Garibay, O., Cadena, J., Merchant, H. and de Lafuente, V., Monkeys share the human ability to internally maintain a temporal rhythm., Frontiers in Psychology , diciembre de 2016; 7(1971), 1-12

12. Petter, E.P. and Merchant H. , Temporal Processing by Intrinsic Neural Network Dynamics, Timing & Time Perception, diciembre de 2016; 4(4), 399-410

13. Mendoza, G., Peyrache, A., Gámez, J., Prado, L., Buzsáki, G. and Merchant, H, Recording extracellular neural activity in the behaving monkey using a semi-chronic, high-density electrode system. , Journal Of Neurophysiology, septiembre de 2016; 116(2), 563-574

14. Merchant, H.* and Yarrow, K. , How the motor system both encodes and influences our sense of time., Current Opinion in Behavioral Sicences, febrero de 2016; 8(1), 22-27

15. Bartolo, R. and Merchant, H*. , Beta oscillations are linked to the initiation of sensory-cued movement sequences and the internal guidance of regular tapping in the monkey., Journal Of Neuroscience, abril de 2015; 35(11), 4635-4640

16. Hoeschele, M., Merchant, H., Hattori, Y., Kikuchi, Y., and ten Cate, C. , Comparative studies on the biology of music: bridging the gap between constrained experiments and natural behavior in the search for animal musicality. , Philosophical Transactions of the Royal Society B: Biological Sciences, marzo de 2015; 370(1664), 232-245

17. Merchant, H*., Grahn, J., Trainer, L., Rohrmeier, M., and Fitch, TW., Finding the beat: A neural perspective across humans and non-human primates., Philosophical Transactions of the Royal Society B: Biological Sciences, marzo de 2015; 370(1664), 186-202

18. Merchant, H.*, Perez, O., Bartolo, R., Mendez JC., Mendoza, G., Gamez, J., Yc, K., Prado, L. , Sensorimotor neural dynamics during isochronous tapping in the medial premotor cortex of the macaque, European Journal Of Neuroscience, marzo de 2015; 41(5), 586-602

19. Merchant, H.* and de Lafuente V. , Introduction to the Neurobiology of Interval Timing. , Advances In Experimental Medicine And Biology, noviembre de 2014; 829, 1-13

20. Merchant, H.*, Bartolo, R., Perez, O., Mendez JC., Mendoza, G., Gamez, J., Yc, K. Prado, L. , Neurophysiology of timing in the hundreds of milliseconds: multiple layers of neuronal clocks in the medial premotor areas. , Advances In Experimental Medicine And Biology, noviembre de 2014; 829, 143-154

21. Mendoza G and Merchant H., Motor system evolution and the emergence of high cognitive functions, Progress In Neurobiology, octubre de 2014; 121(1), 20-41

22. Crowe, D.A., Zarco, W., Bartolo, R., and Merchant, H*. , Dynamic representation of the temporal and sequential structure of rhythmic movements in the primate medial premotor cortex., Journal Of Neuroscience, septiembre de 2014; 34(36), 11972-11983

23. Mendez, J.C., Perez, O., Prado, L., and Merchant, H, Linking perception, cognition, and action: Psychophysical observations and neural network modelling., Plos One, julio de 2014; 9(7), 18

24. Merchant, H., Crowe, D.A., Fortes, A.F., and Georgopoulos, A.P., Cognitive modulation of Neural Synchronicity, Frontiers in Neuroscience, julio de 2014; 8(245), 9

25. Donnet, S., Bartolo, R., Fernandes J.M., Cunha J.P., Prado, L. and Merchant, H, Monkeys time their movement pauses and not their movement kinematics during a synchronization-continuation rhythmic task. , Journal Of Neurophysiology, mayo de 2014; 111(10), 2138

26. Bartolo, R., Prado, L., and Merchant, H, Information processing in the primate basal ganglia during sensory guided and internally driven rhythmic tapping, Journal Of Neuroscience, marzo de 2014; 34(11), 3910-3923

27. Honing H and Merchant H., Differences in auditory timing between human and non-human primates. , Behavioral and Brain Sciences, marzo de 2014; 37(6), 873-874

28. Merchant, H. and Honing, H. , Are non-human primates capable of rhythmic entrainment? Evidence for the gradual audiomotor evolution hypothesis, Frontiers in Neuroscience, enero de 2014; 7(274), 1-9

29. Merchant, H., Harrington, D. and Meck, W.H., Neural Basis of the Perception and Estimation of Time, Annual Review of Neuroscience, mayo de 2013; 36(1), 313-336

30. Merchant, H*., Pérez, O., Zarco, W., and Gámez, J. , Interval tuning in the primate medial premotor cortex as a general timing mechanism , Journal Of Neuroscience, mayo de 2013; 33(21), 9082-9096

31. Perez, O., Kass R.E., Merchant H, Trial time warping to discriminate stimulus-related from movement-related neural activity., Journal of Neuroscience Methods, enero de 2013; 212(2), 203-210

32. Merchant, H,. de Lafuente V., Peña F., Larriva-Sahd J., Functional impact of interneuronal inhibition in the cerebral cortex of behaving animals. , Progress In Neurobiology, noviembre de 2012; 99(2), 163-178

33. Honing, H., Merchant, H., Heden, G., Prado, L. A., and Bartolo, R, Rhesus monkeys (Macaca mulatta) can detect rhythmic groups in music, but not the beat, Plos One, enero de 2012; 7(12), e51369, 1-9

34. DiFabio RP., Merchant, H., Bartolo, R., Tuite P. , Temporal Discrimination Learning for Treatment of Gait Dysfunction In Parkinson’s Disease: A Feasibility Study using Single Subject Design, Journal of Parkinsonism and Restless Legs Syndrome, diciembre de 2011; 1(1), 8-11 online

35. Merchant, H., Zarco W., Perez, O., Prado, L., and Bartolo, R. , Measuring time with multiple neural chronometers during a synchronization-continuation task. , Proceedings Of The National Academy Of Sciences Of The United States Of America, diciembre de 2011; 108(49), 19784-19789.

36. Merchant, H*., Crowe, D.A., Robertson MS., Fortes, A.F. and Georgopoulos, A.P. , Top-down spatial categorization signal from prefrontal to posterior parietal cortex in the primate. , Frontiers in Systems Neuroscience, junio de 2011; 5(69), 1-90 online

37. Mendez, J.C., Prado, L., Mendoza, G and Merchant, H, Temporal and Spatial Categorization in Human and Non-Human Primates, Frontiers in Integrative Neuroscience, abril de 2011; 5(50), 1-10 online

38. Merchant, H, "Apneas" in Purkinje cell activity: Evidence of the bistability of membrane potential in the cerebellum of the awake cat. , Frontiers in Neuroscience, marzo de 2010; 4(1), 6-6 online

39. Zarco, W. Merchant, H., Prado, L. and Mendez J.C., Subsecond timing in primates: comparison of interval production between human subjects and Rhesus monkeys, Journal Of Neurophysiology, diciembre de 2009; 102(6), 3191-3202 online

40. Bartolo, R.O. and Merchant, H, LEARNING AND GENERALIZATION OF TIME PRODUCTION IN HUMANS: RULES OF TRANSFER ACROSS MODALITIES AND INTERVAL DURATIONS., Experimental Brain Research, enero de 2009; 197(1), 91-100

41. Merchant, H. Zarco, W. Prado, L. and Perez O., BEHAVIORAL AND NEUROPHYSIOLOGICAL ASPECTS OF TARGET INTERCEPTION., Advances In Experimental Medicine And Biology, enero de 2009; 629(1), 201-220

42. Merchant, H., Luciana, M., Hooper, C., Majestic, S., Tuite, P., INTERVAL TIMING AND PARKINSON´S DISEASE: HETEROGENEITY IN TEMPORAL PERFORMANCE., Experimental Brain Research, enero de 2008; 184(2), 233-248

43. Merchant, H., Narselaris, T., Georgopoulos, A.P., DYNAMIC SCULPTING OF DIRECTIONAL TUNING BY INTERNEURONS IN THE PRIMATE MOTOR CORTEX DURING 3D REACHING., Journal Of Neuroscience, enero de 2008; 28(37), 9164-9172

44. Merchant, H., Zarco, W., Bartolo, R. and Prado, L., THE CONTEXT OF TEMPORAL PROCESSING IS REPRESENTED IN THE MULTIDIMENSIONAL RELATIONSHIPS BETWEEN TIMING TASKS., Plos One, enero de 2008; 3(9), 1-9

45. Merchant, H., Zarco, W., Prado, L., DO WE HAVE A COMMON MECHANISM FOR MEASURING TIME IN THE HUNDREDS OF MILLISECOND RANGE? EVIDENCE FROM MULTIPLE INTERVAL TIMING TASKS., Journal Of Neurophysiology, enero de 2008; 99(2), 939-949

46. Zarco,W., Merchant H., NEURAL TEMPORAL CODES FOR REPRESENTATION OF INFORMATION IN THE NERVOUS SYSTEM., Cognitive Critique, enero de 2008; 1(1), 1-30

47. Georgopoulos A.P., Merchant H., Narselaris T., Amirikian B., MAPPING OF THE PREFERRED DIRECTION IN THE MOTOR CORTEX., Proceedings Of The National Academy Of Sciences Of The United States Of America, enero de 2007; 104(0), 11068-11072

48. Georgopoulos A.P., Narselaris T., Merchant H., Amirikian B., CONTRASTING INTERPRETATIONS OF THE NON-UNIFORM DISTRIBUTION OF PREFERRED DIRECTIONS WITHIN PRIMARY MOTOR CORTEX., Journal Of Neurophysiology, enero de 2007; 97(0), 4391-4392

49. Merchant H., Georgopoulos A.P., NEUROPHYSIOLOGY OF PERCEPTUAL AND MOTOR ASPECTS OF INTERCEPTION., Journal Of Neurophysiology, enero de 2006; 95(0), 1-13

50. Narselaris T., Merchant H., Amirikian B., Georgopoulos A.P., LARGE-SCALE ORGANIZATION OF PREFERRED DIRECTIONS IN THE MOTOR CORTEX II: ANALYSIS OF LOCAL DISTRIBUTIONS., Journal Of Neurophysiology, enero de 2006; 96(0), 3237-3247

51. Narselaris T., Merchant H., Amirikian B., Georgopoulos A.P., LARGE-SCALE ORGANIZATION OF PREFERRED DIRECTIONS IN THE MOTOR CORTEX I: MOTOR CORTICAL HYPERACUITY FOR FORWARD REACHING., Journal Of Neurophysiology, enero de 2006; 96(0), 3231-3236

52. Merchant H., Battaglia-Mayer A., Georgopoulos A.P., DECODING OF PATH-GUIDED APPARENT MOTION FROM NEURAL ENSEMBLES IN POSTERIOR PARIETAL CORTEX., Experimental Brain Research, enero de 2005; 161(0), 532-540

53. NARSELARIS, T., MERCHANT, H., AMIRIKIAN B., GEORGOPOULOS, A.P., SPATIAL RECONSTRUCTION OF TRAJECTORIES OF AN ARRAY OF RECORDING MICROELECTRODES., Journal Of Neurophysiology, enero de 2005; 93(4), 2318-2330

54. FORTES, A.F., MERCHANT, H., GEORGOPOULOS, A.P., COMPARATIVE AND CATEGORICAL SPATIAL JUDGMENTS IN THE MONKEY HIGH AND LOW., Animal Cognition, enero de 2004; 7(2), 101-107

55. Merchant H., Battaglia-Mayer A., Georgopoulos A.P., NEUROPHYSIOLOGY OF THE PARIETO-FRONTAL SYSTEM DURING TARGET INTERCEPTION., Neurology & Clinical Neurophysiology, enero de 2004; 1(0), 1-5

56. MERCHANT, H., BATTAGLIAMAYER, A., GEORGOPOULOS, A.P., NEURAL RESPONSES DURING INTERCEPTION OF REAL AND APPARENT CIRCULARLY MOVING TARGETS IN MOTOR CORTEX AND AREA 7A., Cerebral Cortex, enero de 2004; 14(3), 314-331

57. MERCHANT, H., BATTAGLIAMAYER, A., GEORGOPOULOS, A.P., NEURAL RESPONSES IN MOTOR CORTEX AND AREA 7A TO REAL AND APPARENT MOTION., Experimental Brain Research, enero de 2004; 154(3), 291-307

58. MERCHANT, H., FORTES, A.F., GEORGOPOULOS, A.P., SHORT TERM MEMORY EFFECTS ON THE REPRESENTATION OF TWO DIMENSIONAL SPACE IN THE RHESUS MONKEY., Animal Cognition, enero de 2004; 7(3), 133-143

59. MERCHANT, H., BATTAGLIAMAYER, A., GEORGOPOULOS, A.P., FUNCTIONAL ORGANIZATION OF PARIETAL NEURONAL RESPONSES TO OPTIC FLOW STIMULI., Journal Of Neurophysiology, enero de 2003; 90(2), 675-682

60. MERCHANT, H., BATTAGLIAMAYER, A., GEORGOPOULOS, A.P., INTERCEPTION OF REAL AND APPARENT CIRCULARLY MOVING TARGETS PSYCHOPHYSICS IN HUMAN SUBJECTS AND MONKEYS., Experimental Brain Research, enero de 2003; 152(1), 106-112

61. MERCHANT, H., BATTAGLIAMAYER, A., GEORGOPOULOS, A.P., EFFECTS OF OPTIC FLOW IN MOTOR CORTEX AND AREA 7A., Journal Of Neurophysiology, enero de 2001; 86(4), 1955-1971

62. VAZQUEZ, J., MERCHANT-NANCY, H., GARCIA, F., DRUCKER-COLIN, R., THE EFFECTS OF SENSORY STIMULATION ON REM SLEEP DURATION., Sleep, enero de 1998; 21(2), 138-142

63. MERCHANT, H., ZAINOS, A., HERNANDEZ, A., SALINAS, E., ROMO, R., FUNCTIONAL PROPERTIES OF PRIMATE PUTAMEN NEURONS DURING THE CATEGORIZATION OF TACTILE STIMULI., Journal Of Neurophysiology, enero de 1997; 77(3), 1132-1154

64. ROMO, R., MERCHANT, H., ZAINOS, A., HERNANDEZ, A., CATEGORICAL PERCEPTION OF SOMESTHETIC STIMULI PSYCHOPHYSICAL MEASUREMENTS CORRELATED WITH NEURONAL EVENTS IN PRIMATE MEDIAL PREMOTOR CORTEX., Cerebral Cortex, enero de 1997; 7(4), 317-326

65. ZAINOS, A., MERCHANT, H., HERNANDEZ, A., SALINAS, E., ROMO, R., ROLE OF PRIMARY SOMATIC SENSORY CORTEX IN THE CATEGORIZATION OF TACTILE STIMULI EFFECTS OF LESIONS., Experimental Brain Research, enero de 1997; 115(2), 357-360

66. ROMO R., MERCHANT, H., ZAINOS, A., HERNANDEZ, A., CATEGORIZATION OF SOMESTHETIC STIMULI SENSORYMOTORPERFORMANCE AND NEURAL ACTIVITY IN PRIMARY SOMATIC SENSORYCORTEX OF AWAKE MONKEYS., Neuroreport, enero de 1996; 7(7), 1273-1279

67. MERCHANT-NANCY, H., VAZQUEZ, J., GARCIA, F., DRUCKER-COLIN, R., BRAIN DISTRIBUTION OF CFOS EXPRESSION AS A RESULT OFPROLONGED RAPID EYE MOVEMENT (REM) SLEEP PERIOD DURATION., Brain Research, enero de 1995; 681(1), 15-22

68. ROMO R., MERCHANT, H., RUIZ S., CRESPO P., ZAINOS, A., NEURONAL ACTIVITY OF PRIMATE PUTAMEN DURING CATEGORICALPERCEPTION OF SOMAESTETIC STIMULI., Neuroreport, enero de 1995; 6(7), 1013-1017

69. SALIN-PASCUAL R., JIMENEZ-ANGUIANO A., DURAN-VAZQUEZ A., MERCHANT-NANCY, H. DRUCKER-COLIN, R., ADMINISTRATION OF AUDITORY STIMULATION DURING RECOVERY AFTER SLEEP DEPRIVATION., Sleep, enero de 1994; 17(3), 231-235

70. ROMO R., RUIZ S., CRESPO P., ZAINOS, A., MERCHANT, H., REPRESENTATION OF TACTILE SIGNALS IN PRIMATE SUPPLEMENTARYMOTOR AREA., Journal Of Neurophysiology, enero de 1993; 70(6), 2690-2694

71. MERCHANT-NANCY H., VAZQUEZ J., AGUILAR-ROBLERO R., DRUCKER-COLIN R., CFOS PROTOONCOGENE CHANGES IN RELATION TO REM SLEEP DURATION., Brain Research, enero de 1992; 579(2), 342-346

Ultimas tesis dirigidas

1. Itzamná Carlos Sánchez Moncada. (estudiante), Bases neurales del aprendizaje y generalización de la percepción del paso del tiempo, Modalidad: Por proyecto de investigación, Maestria en ciencias (Neurobiologia), Maestría, Instituto de Neurobiología UNAM-Juriquilla, Instituto de Neurobiología UNAM-Juriquilla, Fecha de presentación de examen: 29/01/2016, Merchant Nancy Hugo (Director), Concha Loyola Luis (Director)

2. Ramón Bartolo Orozco. (estudiante), BASES NEUROFISIOLOGICAS DE LA PRODUCCION DE INTERVALOS DE TIEMPO EN EL NEOESTRIADO DEL PRIMATE, Modalidad: Tesis, Doctorado en Ciencias Biomédicas, Doctorado, Instituto de Neurobiología UNAM-Juriquilla, UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO, Fecha de presentación de examen: 12/11/2014, Merchant Nancy Hugo (Director)

3. Juan Carlos Méndez Núñez. (estudiante), Neurofisiología de la categorización espacial y temporal en la corteza prefrontal dorsolateral del primate. , Modalidad: Tesis, Doctorado en Ciencias Biomédicas, Doctorado, Instituto de Neurobiología UNAM-Juriquilla, UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO, Fecha de presentación de examen: 07/11/2014, Merchant Nancy Hugo (Director)

4. WILBERT ZARCO (estudiante), ACTIVIDAD NEURONAL DE DOS AREAS DE LA CORTEZA PREMOTORA MEDIAL DEL PRIMATE DURANTE LA PRODUCCION THE INTERVALOS DE TIEMPO, Modalidad: Tesis, Doctorado en Ciencias Biomédicas, Doctorado, Instituto de Neurobiología UNAM-Juriquilla, INB-UNAM, Instituto de Neurobiología UNAM-Juriquilla, Fecha de presentación de examen: 01/04/2011, Merchant Nancy Hugo (Director)

5. Jorge Arturo Gaméz de León. (estudiante), ALGORITMO PARA LA DISCRIMINACION AUTOMATICA DE POTENCIALES DE ACCION REGISTRADOS EXTRACELULARMENTE, Modalidad: Tesis, Maestría en Ciencias, Neurobiología, Maestría, Instituto de Neurobiología UNAM-Juriquilla, INB-UNAM, Instituto de Neurobiología UNAM-Juriquilla, Fecha de presentación de examen: 01/12/2010, Merchant Nancy Hugo (Director)

Ultimos libros publicados

1. Hugo Merchant and Victor de Lafuente , Neurobiology of interval timing, 1, 1, , Estados Unidos de América, ISBN: 978-1-4939-1781-5, noviembre de 2014

Capítulos en libros recientes

1. Merchant H., Georgopoulos, AP. , Handbook of Brain Microcircuits. , 4, 4, , Estados Unidos de América, ISBN: g, octubre de 2017

2. Hugo Merchant* and Victor de Lafuente., Neurobiology of Interval Timing, 1, 1, , Estados Unidos de América, diciembre de 2013

3. Merchant, H., Bartolo, R., Perez, O., Mendez JC., Mendoza, G., Gamez, J., Yc, K. Prado, L. , Neurobiology of interval timing, 1, 1, , Estados Unidos de América, diciembre de 2013

4. Meck W.H., Doyere, V., Gruart A., Frontiers in Timing Neuroscience. , 1, 1, , Suiza, 2012

5. Merchant, H., Propiedades emergentes de redes neuronales, su relevancia en procesos motores y cognitivos y en el desarrollo de la conciencia, 1, 1a, , México, abril de 2012