Plataforma de Información Curricular

Research Interest

Molecular and Biochemical Mechanisms of Biological Clock in the Liver and Muscle. Synchronization of Circadian Clock by Feeding Restriction.
Role of Hepatic Glutamate System Components in Physiological and Inflammatory Conditions: Fibrosis, Cirrhosis and Hepatocarcinoma.

Most Recent Publications

1. MÉNDEZ I, HERNÁNDEZ-ABREGO A, GARCÍA GAYTÁN AC, DE ITA-PÉREZ D, DE LOS RÍOS EA, TURRUBIATE PAZ I, GÁMEZ-ROSAS E, DÍAZ-MUÑOZ M, Expression and role of the metabotropic glutamate receptor type 3 in hepatocarcinoma", Journal of Hepatology, July 2023; 78(S1), S547-S548 online

2. FLORES-ESPINOSA P, MÉNDEZ I, IRLES C, OLMOS-ORTIZ A, HELGUERA-REPETTO C, MANCILLA-HERRERA I, ORTUÑO-SAHAGÚN D, GOFFIN V, ZAGA-CLAVELLINA V, Immunomodulatory role of decidual prolactin on the human fetal membranes and placenta, Frontiers in Immunology, May 2023; 14, 1-11 online

3. GARCÍA-GAYTÁN AC, HERNÁNDEZ-ABREGO A, DÍAZ-MUÑOZ M, MÉNDEZ I., Glutamatergic system components as potential biomarkers and therapeutic targets in cancer in non-neural organs, Frontiers in Endocrinology, November 2022, 1-20 online

4. RAMÍREZ-VENEGAS G, DE ITA-PÉREZ D, DÍAZ-MUÑOZ M, MÉNDEZ I, GARCÍA-GASCA T, AHUMADA-SOLÓRZANO M, ZAMBRANO-ESTRADA X, VÁZQUEZ-MARTÍNEZ O, GUZMÁN-MALDONADO H, LUNA-MORENO D, Supplementation with Phaseolus vulgaris leaves improves metabolic alterations induced by high-fat/fructose diet in rats under time-restricted feeding, Plant Foods For Human Nutrition, September 2021; 76(3), 297-303 online

5. GARCÍA-GAYTÁN AC, MIRANDA-ANAYA M, TURRUBIATE I, LÓPEZ-DE PORTUGAL L, BOCANEGRA-BOTELLO GN, LÓPEZ-ISLAS A, DÍAZ-MUÑOZ M, MÉNDEZ I, Synchronization of the circadian clock by time-restricted feeding with progressive increasing calorie intake. Resemblances and differences regarding a sustained hypocaloric restriction, Scientific Reports, June 2020; 10(10036), 1-17 online

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Publicaciones

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1. MÉNDEZ I, HERNÁNDEZ-ABREGO A, GARCÍA GAYTÁN AC, DE ITA-PÉREZ D, DE LOS RÍOS EA, TURRUBIATE PAZ I, GÁMEZ-ROSAS E, DÍAZ-MUÑOZ M, Expression and role of the metabotropic glutamate receptor type 3 in hepatocarcinoma", Journal of Hepatology, July 2023; 78(S1), S547-S548 online

2. FLORES-ESPINOSA P, MÉNDEZ I, IRLES C, OLMOS-ORTIZ A, HELGUERA-REPETTO C, MANCILLA-HERRERA I, ORTUÑO-SAHAGÚN D, GOFFIN V, ZAGA-CLAVELLINA V, Immunomodulatory role of decidual prolactin on the human fetal membranes and placenta, Frontiers in Immunology, May 2023; 14, 1-11 online

3. GARCÍA-GAYTÁN AC, HERNÁNDEZ-ABREGO A, DÍAZ-MUÑOZ M, MÉNDEZ I., Glutamatergic system components as potential biomarkers and therapeutic targets in cancer in non-neural organs, Frontiers in Endocrinology, November 2022, 1-20 online

4. RAMÍREZ-VENEGAS G, DE ITA-PÉREZ D, DÍAZ-MUÑOZ M, MÉNDEZ I, GARCÍA-GASCA T, AHUMADA-SOLÓRZANO M, ZAMBRANO-ESTRADA X, VÁZQUEZ-MARTÍNEZ O, GUZMÁN-MALDONADO H, LUNA-MORENO D, Supplementation with Phaseolus vulgaris leaves improves metabolic alterations induced by high-fat/fructose diet in rats under time-restricted feeding, Plant Foods For Human Nutrition, September 2021; 76(3), 297-303 online

5. GARCÍA-GAYTÁN AC, MIRANDA-ANAYA M, TURRUBIATE I, LÓPEZ-DE PORTUGAL L, BOCANEGRA-BOTELLO GN, LÓPEZ-ISLAS A, DÍAZ-MUÑOZ M, MÉNDEZ I, Synchronization of the circadian clock by time-restricted feeding with progressive increasing calorie intake. Resemblances and differences regarding a sustained hypocaloric restriction, Scientific Reports, June 2020; 10(10036), 1-17 online

6. MÉNDEZ I, DÍAZ-MUÑOZ M, Circadian and Metabolic Perspectives in the Role Played by NADPH in Cancer, Frontiers in Endocrinology, March 2018; 9, 1-6 online

7. LÓPEZ-ISLAS A, GAZCA MARTÍNEZ D, MENDEZ I, , Estado metabólico en ratas bajo protocolos de restricción temporal de alimento, Padi Boletín Científico de Ciencias Básicas e Ingenierías del ICBI, January 2021; 8, 37-41 online

8. FLORES-ESPINOSA P, VEGA-SÁNCHEZ R, MANCILLA-HERRERA I, BERMEJO-MARTÍNEZ L, PRECIADO-MARTÍNEZ E, OLMOS-ORTIZ A, MÉNDEZ I, ESTRADA-GUTIÉRREZ G, QUESADA-REYNA B, HELGUERA-REPETTO C, IRLES C, ZAGA-CLAVELINA V, Prolactin selectively inhibits the LPS-induced chemokine secretion of human foetal membranes, The Journal of Maternal-Fetal & Neonatal Medicine, December 2020; 33(24), 483-489 online

9. SOTO- ARREDONDO KJ, ROBLES J, DIAZ-CERVANTES E, RUIZ-RAMIREZ C, GARCÍA REVILLA M, WROBEL K, WROBEL K, DIAZ-MUÑOZ M, MÉNDEZ I, FLORES A, ACEVEDO-AGUILAR FJ, MARTÍNEZ-ALFARO M, Effects of lead and lead–melatonin exposure on protein and gene expression of metal transporters, proteins and the copper/zinc ratio in rats, Biometals, July 2018 online

10. GONZÁLEZ L, LIRA-ALBARRÁN S, MÉNDEZ I, DIAZ L, LARREA F, The role of the ovarian cycle and the effects of mitogen-induced cytokines on human prolactin gene expression in peripheral blood mononuclear cells, Endocrine Research, February 2018; 43(1), 39-46 online

11. FLORES-ESPINOSA P, PRECIADO-MARTÍNEZ E, MEJÍA-SALVADOR A, SEDANO-GONZÁLEZ G, BERMEJO-MARTÍNEZ L, PARRA-COVARRUVIAS A, ESTRADA-GUTIÉRREZ G, VEGA-SÁNCHEZ R, MÉNDEZ I, QUESADA-REYNA B, OLMOS-ORTÍZ A, ZAGA-CLAVELINA V, Selective immuno-modulatory effect of prolactin upon pro-inflammatory response in human fetal membranes, Journal of Reproductive Immunology, September 2017; 123, 58-64 online

12. VÁZQUEZ-MARTÍNEZ O, MÉNDEZ I, TURRUBIATE I, VALENTE-GODÍNEZ H, PÉREZ-MENDOZA M, GARCÍA-TEJADA P, DÍAZ-MUÑOZ M, Restricted feeding modulates the daily variations of liver glutamate dehydrogenase activity, expression and histological location, Experimental Biology and Medicine, March 2017; 242(9), 945-952 online

13. MÉNDEZ I, VÁZQUEZ-MARTÍNEZ O, HERNÁNDEZ-MUÑOZ R, VALENTE-GODÍNEZ H, DÍAZ-MUÑOZ M, Redox regulation and pro-oxidant reactions in the physiology of circadian systems. In special issue “Metabolism in the 21st Century – Advances in Aging and Obesity”, Biochimie, October 2016; 124, 178-186 online

14. DÍAZ L, DÍAZ-MUÑOZ M, GARCÍA GAYTÁN AC, MÉNDEZ I, Mechanistic effects of calcitriol in cancer biology, Nutrients, June 2015; 7, 5020-5050 online

15. VALDÉS-FUENTES M, VERA-RIVERA G, DE ITA-PÉREZ D, MÉNDEZ I, MIRANDA M I, DÍAZ-MUÑOZ M, Effect of daytime-restricted feeding in the daily variations of liver metabolism and blood transport of serotonin in rat, Physiological Reports, May 2015; 3(e12389), 1-13 online

16. HERNÁNDEZ-PLATA E, QUIROZ-COMPEÁN F, RAMÍREZ-GARCIA G, YÁÑEZ BARRIENTOS E, RODRÍGUEZ-MORALES N, FLORES A, WROBEL K, WROBEL K, MÉNDEZ I, DÍAZ-MUÑOZ M, ROBLES J, MARTÍNEZ-ALFARO M., Melatonin reduces lead levels in blood, brain and bone and increases lead excretion in rats subjected to subacute lead treatment, Toxicology Letters, February 2015; 233, 78-83 online

17. LEMINI M, RUIZ-HERRERA X, LÓPEZ-BARRERA F, MÉNDEZ I, MARTÍNEZ DE LA ESCALERA G, MACOTELA Y, CLAPP C, Prolactin anterior pituitary expression and circulating levels are reduced in obese and diabetic rats: Role of TGFβ and TNFα, AMERICAN JOURNAL OF PHYSIOLOGY: Regulatory, Integrative and Comparative Physiology, February 2015; 308(9), R792-R799 online

18. VÁZQUEZ-MARTÍNEZ O, DE ITA-PÉREZ D, VALDÉS-FUENTES M, FLORES-VIDRIO A, MÉNDEZ I, DÍAZ-MUÑOZ M, Molecular and biochemical modifications of liver glutamine synthetase elicited by daytime restricted feeding, Liver International, October 2014; 34(9), 1391-1401 online

19. ZAMORANO M, LEDESMA-COLUNGA MG, ADÁN N, VERA-MASSIEU C, LEMINI M, MÉNDEZ I, MORENO-CARRANZA B, NEUMAN I, THEBAULT S, MARTÍNEZ DE LA ESCALERA G, TORNER L, CLAPP C., Prolactin-derived vasoinhibins increase anxiety- and depression-related behaviors, Psychoneuroendocrinology, June 2014; 44, 123-132 online

20. GUZMÁN C, GARCÍA-BECERRA R, AGUILAR-MEDINA MA, MÉNDEZ I, MERCHANT-LARIOS H, ZAMBRANO E,, Maternal protein restriction during pregnancy and/or lactation negatively affects follicular ovarian development and steroidogenesis in the prepubertal rat offspring, Archives Of Medical Reseach, May 2014; 45(4), 294-300 online

21. DE ITA-PÉREZ D, MÉNDEZ I, VÁZQUEZ-MARTÍNEZ O, VILLALOBOS-LEAL M, MAURICIO DÍAZ-MUÑOZ, Synchronization by food access modifies the daily variations in expression and activity of liver GABA transaminase, BioMed Research International, April 2014, 1-8 online

22. ADÁN N, GUZMÁN-MORALES J, LEDESMA-COLUNGA G, PERALES-CANALES SI, QUINTANAR-STÉPHANO A, LÓPEZ-BARRERA F, MÉNDEZ I, MORENO-CARRANZA B, TRIEBEL J, BINART N, MARTÍNEZ DE LA ESCALERA G, THEBAULT S, AND CLAPP C, Prolactin promotes cartilage survival and attenuates inflammation in inflammatory arthritis, Journal Of Clinical Investigation, April 2013; 123(9), 3902-3913 online

23. DÍAZ L, MARTÍNEZ-REZA I, GARCÍA-BECERRA R, GONZÁLEZ L, LARREA F, MÉNDEZ I, Calcitriol stimulates prolactin expression in non-activated human peripheral blood mononuclear cells: Breaking paradigms, Cytokine, August 2011; 55(2), 188-194 online

24. VEGA C, MORENO-CARRANZA B, ZAMORANO M, QUINTANAR-STÉPHANO A, MÉNDEZ I, THEBAULT S, MARTÍNEZ DE LA ESCALERA G, CLAPP C, Prolactin promotes oxytocin and vasopressin release by activating neuronal nitric oxide synthase in the supraoptic and paraventricular nuclei, AMERICAN JOURNAL OF PHYSIOLOGY: Regulatory, Integrative and Comparative Physiology, October 2010; 299(1), R-1701 - R1708

25. MÉNDEZ I, VEGA C, ZAMORANO M, MORENO-CARRANZA B, MARTÍNEZ DE LA ESCALERA G, AND CLAPP C., Vasoinhibins and the pituitary gland. , Frontiers Of Hormone Research, July 2010; 38(1), 184-189

26. BARRERA D, AVILA E, HERNÁNDEZ G, MÉNDEZ I, GONZÁLEZ L, HALHALI A, LARREA F, MORALES A, DÍAZ L, Calcitriol affects hCG gene transcription in cultured human syncytiotrophoblasts., Reproductive Biology And Endocrinology, January 2008; 6(3), 1-8 online

27. AVILA E, DÍAZ L, BARRERA D, HALHALI A, MÉNDEZ I, GONZÁLEZ L, LARREA F, ZUEGEL U, Regulation of vitamin D hydrocylases gene expression by 1,25-dihydroxyvitamin D3 and cyclic AMP in cultured human syncytiotrophoblasts., Journal Of Steroid Biochemistry And Molecular Biology, January 2007; 103(1), 90-96

28. MÉNDEZ I, GONZÁLEZ L, MARTÍNEZ I., La prolactina: una hormona que también es citocina., Revista De La Escuela De Medicina "Dr. José Sierra Flores" De La Universidad Del Noreste, January 2007; 21(0), 4-11

29. LARREA F, SANCHEZ-GONZALEZ S, GARCIA-BECERRA R, MENDEZ I, Sitios de acción inhibitoria de la prolactina sobre la síntesis de estradiol inducida por la hormona folículo estimulante en las células de la granulosa., Gaceta Medica De México, January 2005; 141(4), 259-266

30. MENDEZ I, CARIÑO C, DIAZ L, Prolactin in the immunological system; synthesis and biological effects., Revista de Investigacion Clinica, January 2005; 57(3), 447-456

31. MENDEZ I, ALCOCER-VARELA J, PARRA A, LARA-ZAVALA A, DE LA CRUZ DA, ALARCON-SEGOVIA D, LARREA F, Neuroendocrine dopaminergic regulation of prolactin release in systemic lupus erythematosus a possible role of lymphocyte-derived prolactin., Lupus, January 2004; 13(0), 45-53

32. CARIÑO C, DIAZ L, MENDEZ I, Zona pellucida antigens in the human oocyte. Its relevance in contraceptive strategies., Revista de Investigacion Clinica, January 2001; 53(0), 174-180

33. DIAZ L, CARIÑO C, MENDEZ I, La vitamina D: implicaciones en la salud y el embarazo., Revista de Investigacion Clinica, January 2001; 53(1), 77-85

34. GONZALEZ-ARENAS A, REYNA-NEYRA A, GOMEZ M, MENDEZ I, LARRIETA-CARRASCO ME, HACES M, JIMENEZ B, CAMACHO-ARROYO I, Los mensajeros químicos del sistema neuroinmunoendocrino., Educacion Quimica, January 2001; 12(3), 158-162

35. CABRERA V, RODRIGUEZ JC, MENDEZ I, LARREA F, CHAPE F, Caracterización bioquímica de la prolactina de diferentes especies., Revista Cubana De Endocrinologia, January 2000; 11(2), 78-89

36. HERNANDEZ I, PARRA A, MENDEZ I, CABRERA V, CRAVIOTO MC, MERCADO M, DIAZ-SANCHEZ V, LARREA F, Hypothalamic dopaminergic tone and prolactin bioactivity in women with polycystic ovary syndrome., Archives Of Medical Reseach, January 2000; 31(0), 216-222

37. LARREA F, SANCHEZ-GONZALEZ S, MENDEZ I, GARCIA-BECERRA R, CABRERA V, ULLOA-AGUIRRE A, G protein-coupled receptors as targets for prolactin actions., Archives Of Medical Reseach, January 1999; 30(0), 532-543

38. VILLANUEVA LA , MENDEZ I , AMPUERO S, LARREA F, The prolactin inhibition of follicle-stimulating hormone-induced aromatase activity in cultured rat granulosa cells is in part tyrosine kinase and protein kinase-c dependent., Molecular Human Reproduction, January 1996; 2(10), 725-731

39. LARREA F , SANDOVAL JL, SALINAS E, FRANCO-RODRIGUEZ VA ,MENDEZ I , ULLOA-AGUIRRE A, Evidence for an altered luteinizing hormone sensitivity to naloxone in pathological hyperprolactinaemia., Clinical Endocrinology, January 1995; 43(0), 591-600

40. LARREA F , MENDEZ I , CARIÑO C, DIAZ L, Conceptos actuales sobre fisiología de la prolactina: variantes moleculares y mecanismos de acción., Revista de Investigacion Clinica, January 1993; 45(4), 375-386

41. LARREA F, MENDEZ I , PARRA A , ESPINOSA DE LOS MONTEROS A, Serum pattern of different molecular forms of prolactin during normal human pregnancy., Human Reproduction, January 1993; 8(10), 1617-1622

42. LARREA F, MENDEZ I , ESCORZA A, VEAYRA F, CARIÑO C, CRAVIOTO MC, Prolactin size variants during pregnancy in women with ovulatory hyperprolactinemia: characterization by isoelectric focusing and lectin affinity chromatography., European Journal Of Obstetrics & Gynecology And Reproductive Biology, January 1992; 44(0), 91-100

43. LARREA F , ESCORZA A , MENDEZ I , RUIZ JE , VALERO A , CRAVIOTO MC, Variantes de prolactina en suero y liquido amniotico de mujeres con hiperprolactinemia ovulatoria., Revista de Investigacion Clinica, January 1991; 43(0), 245-251

44. LARREA F, ESCORZA A , VALENCIA X , MENDEZ I , SCHIAVON R, FORSBACH G, Reduced dopaminergic inhibition of tyrotropin release in hyperprolactinemic ovulatory women., Revista de Investigacion Clinica, January 1991; 43(0), 293-298

Most Recent Advised Theses

1. Ana Cristina García Gaytán (estudiante), Expresión del receptor metabotrópico tipo 3 del glutamato (mGluR3) en la progresión de daño hepático y su papel en la inflamación, Modalidad: Tesis, Doctorado en Ciencias Biomédicas, Doctorado, Instituto de Neurobiología UNAM-Juriquilla, Universidad Nacional Autónoma de México, Fecha de presentación de examen: 2024-10-01, Méndez Hernández Isabel C. (Director)

2. Jesús Salvador Pérez Arredondo (estudiante), nálisis de la inducción de especies reactivas de oxígeno por nanoparticulas de hierro y el efecto de la activación del receptor metabotrópico tipo 3 de glutamato en la proliferación en células de hígado sanas, Modalidad: Tesina, Licenciatura en Terarapia Física, Licenciatura, Universidad Politécnica de Santa Rosa, Universidad Politécnica de Santa Rosa, Fecha de presentación de examen: 2023-01-27, Méndez Hernández Isabel C. (Director)

3. Andy Brian Hernández Abrego (estudiante), Caracterización de componentes del sistema glutamatérgico en células hepáticas sanas y derivadas de hepatocarcinoma bajo un ambiente inflamatorio, Modalidad: Tesis, Maestría en Ciencias Bioquímicas, Maestría, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Fecha de presentación de examen: 2022-12-01, Méndez Hernández Isabel C. (Director)

4. José Fernando Hurtado Acosta (estudiante), Análisis de la inducción de especies reactivas de oxigeno por nanopartículas de hierro y la activación de receptores de glutamato en células derivadas de hepatoma., Modalidad: Tesis, Licenciatura en Terapia Física, Licenciatura, UPSRJ, Universidad Politécnica de Santa Rosa Jáuregui, Fecha de presentación de examen: 2021-01-22, Méndez Hernández Isabel C. (Director)

5. Guadalupe Nayeli Bocanegra Botello (estudiante), Biocompatibilidad de nanopartículas de hierro sintetizadas por métodos electroquímicos, Modalidad: Tesis, Licenciatura en Terapia Física, Licenciatura, UPSRJ, Universidad Politécnica de Santa Rosa Jáuregui, Fecha de presentación de examen: 2019-04-16, Méndez Hernández Isabel C. (Director)

Most Recent Published Books

1. Isabel Méndez, Fernando Larrea, Regulación Dopaminérgica Neuroendocrina de la Prolactina en el Lupus. De la autoinmunidad a la neuroendocrinología., 1, 1a, , España, ISBN: 978-3-8484-7602-2, May 2012

Most Recent Chapters in Books

1. Méndez I, Díaz-Muñoz M, Circadian and metabolic perspectives in the role played by NADPH in cancer. En: Disorders of Circadian Rhythms, , 1a, , Suiza, ISBN: 978-2-88966-131-2, September 2020

2. Méndez I, Vázquez-Cuevas F, Hernández-Muñoz R, Valente-Godínez H, Vázquez-Martínez O, Díaz-Muñoz M, Redox reactions in the physiopathology of the liver. En:Redox: Principles and Advance Applications, , 1, , Croacia, ISBN: 978-953-51-3394-0, September 2017

3. Méndez I, Al otro lado del espejo y como devine en investigador, , 1a, , México, December 2015

4. Díaz L, Díaz-Muñoz M, González L, Lira-Albarrán S, Larrea F, Méndez I., Prolactin in the immune system. Prolactin, , 1a, , Croacia, ISBN: ISBN 980-953-307-165-2, January 2013

5. Moreno-Carranza, Méndez I, Martínez de la Escalera G, Clapp C., Las prolactinas: angiogénesis y antiangiogénesis. Clínicas de perinatología y reproducción humana. Endocrinología reproductiva, 1, 1, , México, ISBN: 970-9793-18-7, December 2009