Plataforma de Información Curricular

Review

The study of glial cells has been my passion since my Ph.D. I started with patch-clamp recordings in astrocytes and studied the functional expression of potassium channels and neurotransmitter receptors. I continued with these studies in the calyx of Held synapse, an excellent model to investigate about neuron-glial communication during my postdoc. Later, I returned to Mexico and our team is currently studying the dysfunction of glial cells in murine models of anorexia and autism. Additionally, we started with the Organization of the Symposium on Physiology and Pathology of Neuroglia.

Research Interest

Physiology of glial cells in murine models of autism
Physiology of neuroglia in anorexia

Most Recent Publications

1. Saavedra-Bonilla H, Varman DR, Reyes-Haro D, Spontaneous Calcium Transients Recorded from Striatal Astrocytes in a Preclinical Model of Autism, Neurochemical Research, November 2024; 49(11), 3069-3077

2. Reyes-Haro D, Glial cells in anorexia, Frontiers in Cellular Neuroscience, November 2022; 16, 983577

3. Soria-Ortiz MB, Reyes-Ortega P, Martínez-Torres A, Reyes-Haro D, A functional network signature in the developing cerebellum: evidence from a preclinical model of autism, Frontiers in Cell and Developmental Biology, September 2021; 10(1), 727079

4. Reyes-Haro D, Cisneros-Mejorado A, Arellano RO, Therapeutic potential of GABAergic signaling in myelin plasticity and repair, Frontiers in Cell and Developmental Biology, April 2021; 9(1), 662191

5. Labrada-Moncada FE, Martínez-Torres A, Reyes-Haro D, GABA A Receptors are Selectively Expressed in NG2 Glia of the Cerebellar White Matter, Neuroscience, September 2020; 433(1), 132-143

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Publicaciones

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1. Saavedra-Bonilla H, Varman DR, Reyes-Haro D, Spontaneous Calcium Transients Recorded from Striatal Astrocytes in a Preclinical Model of Autism, Neurochemical Research, November 2024; 49(11), 3069-3077

2. Reyes-Haro D, Glial cells in anorexia, Frontiers in Cellular Neuroscience, November 2022; 16, 983577

3. Soria-Ortiz MB, Reyes-Ortega P, Martínez-Torres A, Reyes-Haro D, A functional network signature in the developing cerebellum: evidence from a preclinical model of autism, Frontiers in Cell and Developmental Biology, September 2021; 10(1), 727079

4. Reyes-Haro D, Cisneros-Mejorado A, Arellano RO, Therapeutic potential of GABAergic signaling in myelin plasticity and repair, Frontiers in Cell and Developmental Biology, April 2021; 9(1), 662191

5. Labrada-Moncada FE, Martínez-Torres A, Reyes-Haro D, GABA A Receptors are Selectively Expressed in NG2 Glia of the Cerebellar White Matter, Neuroscience, September 2020; 433(1), 132-143

6. Reyes-Ortega P, Ragu-Varman D, Rodrìguez VM, Reyes-Haro D, Anorexia induces a microglial associated pro-inflammatory environment and correlates with neurodegeneration in the prefrontal cortex of young female rats, Behavioural Brain Resaerch, August 2020; 392(1), 112606

7. Ragu-Varman D, Macedo-Mendoza M, Labrada-Moncada FE, Reyes-Ortega P, Morales T, Martínez-Torres A, Reyes-Haro D, Anorexia increases microglial density and cytokine expression in the hippocampus of young female rats, Behavioural Brain Research, September 2019; 363, 118-125

8. Varman DR, Soria-Ortiz MB, Martínez-Torres A, Reyes-Haro D, Cerebellar GABA3 expression is reduced in the valproic acid model of autism, Neuroscience Letters, November 2018; 687, 158-163

9. Reyes-Haro D, Hernández-Santos JA, Miledi R, Martínez-Torres A., GABArho selective antagonist TPMPA partially inhibits GABA-mediated currents recorded from neurones and astrocytes in mouse striatum, Neuropharmacology, February 2017; 113(Pt A), 407-415

10. Reyes-Haro D, Labrada-Moncada FE, Varman DR, Krüger J, Morales T, Miledi R, Martínez-Torres A, Anorexia reduces GFAP+ cell density in the rat hippocampus, Neural Plasticity, August 2016; 2016(2016), 2426413

11. Reyes-Haro D, Labrada-Moncada FE, Miledi R, Martínez-Torres A, Dehydration-induced anorexia reduces astrocyte density in the rat corpus callosum, Neural Plasticity, March 2015; 2015, 8

12. Pétriz A, Reyes-Haro D, González-González MA, Miledi R, Martínez-Torres A, GABArho subunits confer a bicuculline-insensitive component to GFAP+ cells of cerebellum, Proceedings Of The National Academy Of Sciences Of The United States Of America, December 2014; 111(49), 17522-17527

13. Reyes-Haro D, Bulavina L, Pivneva T, La glía, el pegamento de las ideas, Ciencia, April 2014; 65(2), 12-18

14. Reyes-Haro D, Cabrera-Ruiz E, Estrada-Mondragón A, Miledi R, Martínez-Torres A, Modulation of GABA-A receptors of astrocytes and STC-1 cells by taurine structural analogs, Amino Acids, February 2014; 46(11), 2587

15. Reyes-Haro D, Mora-Loyola E, Soria-Ortiz B, García-Colunga J., Regional density of glial cells in the rat corpus callosum, Biological Research, March 2013; 46(1), 27-32

16. Reyes-Haro D, López-Juárez A, Rodríguez-Contreras A, Editorial: Physiology and pathology of neuroglia. , Frontiers in Cellular Neuroscience, November 2023; 17(1246885), 3

17. Rosas-Arellano A, Estrada-Mondragón A, Martínez-Torres A, Reyes-Haro D., GABAA-ρ Receptors in the CNS: Their Functional, Pharmacological, and Structural Properties in Neurons and Astroglia, Neuroglia, October 2023; 4(4), 14

18. Hernández A, Delgado-González E, Ragu-Varman D, Reyes-Haro D, Martínez-Torres A, Espinosa F, Striatal synaptic changes and behavior in adult mouse upon prenatal exposure to valproic acid, Brain Research, September 2023; 1815(148461)

19. Reyes-Haro D, Montiel-Herrera M, La excitabilidad de las células gliales, e-Neurobiología, July 2022; 13(32), 220822

20. Montiel-Herrera M, García-Villa D, López-Cervantes G, Reyes-Haro D, Domínguez-Ávila JA, González-Aguilar GA, The role of ion channels on the physiology of the neurovascular unit and the regulation of cerebral blood flow, J Cell Neurosci Oxid Stress, February 2022; 13(2), 1004-1013

21. Reyes-Ortega P, Soria-Ortiz MB, Rodríguez VM, Vázquez-Martínez EO, Díaz-Muñoz M, Reyes-Haro D., Anorexia disrupts glutamate-glutamine homeostasis associated with astroglia in the prefrontal cortex of young female rats, Behavioural Brain Research, February 2022; 420, 113715

22. Cabrera-Muñoz EA, Olvera-Hernández S, Vega-Rivera NM, Meneses-San Juan D, Reyes-Haro D, Ortiz-Lopez L, Ramirez Rodriguez GB, Environmental enrichment differentially activates neural circuits in FVB/N mice, inducing social interaction in females but agonistic behavior in males, Neurochemical Research, January 2022; 47(3), 781-794

23. Reyes-Haro D, González-González MA, Pétriz A, Rosas-Arellano A, Kettenmann H, Miledi R, Torres-Martínez A, GABArho expression in ependymal glial cells of the mouse cerebellum, Journal Of Neuroscience Research, April 2013; 91(4), 527-534

24. Reyes-Haro D, Rosas-Arellano A, González-González A, Mora-Loyola E, Miledi R, Martínez-Torres A, GABAρ expression in the medial nucleus of the trapezoid body., Neuroscience Letters, January 2013; 532(00), 23-28

25. Rosas-Arellano A, Machuca-Parra AI, Reyes-Haro D, Miledi R, Martínez-Torres A., Expression of GABAρ receptors in the neostriatum: localization in aspiny, medium spiny neurons and GFAP-positive cells., Journal of Neurochemistry, September 2012; 122(5), 900-910

26. Martínez-Delgado G., Reyes-Haro D., Espino-Saldaña AE., Rosas-Arellano A., Pétriz-Reyes A., Juárez-Mercado P., Miledi R. & Martínez-Torres A., Dynamics of GABArho2 receptors in retinal bipolar neurons and in cerebellar astrocytes., Neuroreport, January 2011; 22(1), 4-9

27. Reyes-Haro D., Muller J., Boresch M., Pivneva T., Benedetti B., Scheller A., Nolte C & Kettenmann H., Neuron-astrocyte interactions in the medial nucleus of the trapezoid body, Journal Of General Physiology, June 2010; 135(6), 583-594

28. Müller,J., Reyes-Haro, D., Pivneva, T., Nolte, C., Schaette, R., Lübke, J., & Kettenmann, H. , The principal neurons of the medial nucleus of the trapezoid body and a NG2+ glial cell receive coordinated excitatory synaptic input. , Journal Of General Physiology, July 2009; 134(2), 115-127

29. Pivneva, T., Haas, B., Reyes-Haro, D., Laube, G., Veh, R.W., Nolte, C., Skibo, G., & Kettenmann, H., Store-operated Ca(2+) entry in astrocytes: Different spatial arrangement of endoplasmic reticulum explains functional diversity in vitro and in situ., Cell Calcium, June 2008; 43(6), 591-601

30. Reyes-Haro, D., García-Colunga, J., & Miledi, R. , Potassium currents in primary cultured astrocytes from the rat corpus callosum., Journal Of Neurocytology, December 2005; 34(6), 411 - 420

31. García-Colunga, J., Reyes-Haro, D., Godoy-García, U., & Miledi, R., Zinc Modulation of Serotonin Uptake in the Adult Rat Corpus Callosum. , Journal Of Neuroscience Research, February 2005; 80(1), 145-149

32. Reyes-Haro, D., García-Alcocer, G., Miledi, R., & García-Colunga, J. , Uptake of serotonin by adult rat corpus callosum is partially reduced by common antidepressants. , Journal Of Neuroscience Research, August 2003; 74(1), 97-102

33. Reyes-Haro, D., & Salceda, R., The High Affinity Glutamate Transporters in the Nervous System: Structure, Function and Physiological Relevance. , Archivos De Neurociencias, April 2000; 5(2), 96-102

Most Recent Advised Theses

1. María Berenice Soria Ortiz (estudiante), Fisiología de los astrocitos en un modelo murino de autismo inducido por ácido valpróico, Modalidad: Tesis, Programa de Doctorado en Ciencias Biomédicas, Doctorado, Instituto de Neurobiología UNAM-Juriquilla, Instituto de Neurobiología UNAM-Juriquilla, Fecha de presentación de examen: 2023-09-20, Reyes Haro Daniel (Director)

2. Esmeralda Cardona Arriaga (estudiante), Fisiología de los ensambles gliales de la sustancia blanca en un modelo pre-clínico de autismo, Modalidad: Por proyecto de investigación, Maestría en Ciencias (Neurobiología), Maestría, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Fecha de presentación de examen: 2023-01-24, Reyes Haro Daniel (Director)

3. Francisco Emmanuel Labrada Moncada (estudiante), Expresión funcional de receptores GABA-A en los astrocitos de la sustancia blanca del cerebelo de ratón, Modalidad: Tesis, Programa de Doctorado en Ciencias Biomédicas, Doctorado, Instituto de Neurobiología UNAM-Juriquilla, Instituto de Neurobiología UNAM-Juriquilla, Fecha de presentación de examen: 2022-12-15, Reyes Haro Daniel (Director)

4. Pamela Reyes Ortega (estudiante), 1. La anorexia induce un ambiente pro-inflamatorio asociado a la microglía y neurodegeneración en la corteza prefrontal de la rata, Modalidad: Tesis, Programa de Doctorado en Ciencias Biomédicas, Doctorado, Instituto de Neurobiología UNAM-Juriquilla, Instituto de Neurobiología UNAM-Juriquilla, Fecha de presentación de examen: 2021-08-16, Reyes Haro Daniel (Director)

5. Oscar Saúl Morales Tafoya (estudiante), Efecto de la exposición postnatal del valproato sobre la actividad glial del cuerpo calloso, Modalidad: Por artículo de investigación, Programa de Maestría en Ciencias (Neurobiología), Maestría, Instituto de Neurobiología UNAM-Juriquilla, Instituto de Neurobiología UNAM-Juriquilla, Fecha de presentación de examen: 2020-03-31, Reyes Haro Daniel (Director)