Plataforma de Información Curricular

Research Interest

Hormonal regulation of metabolism
Milk prolactin actions on the physiology of the nursing young.

Most Recent Publications

1. Ferreira SRG*, Macotela Y*, Velloso LA, Mori MA. *Igual Contribución., Determinants of obesity in Latin America., Nature Metabolism, March 2024; 6(3), 409-432

2. Luzardo-Ocampo I, Ocampo-Ruiz AL, Dena-Beltrán JL, Martínez de la Escalera G, Clapp C, Macotela Y*. *Autor de correspondencia., The Diversity of Gut Microbiota at Weaning Is Altered in Prolactin Receptor-Null Mice., Nutrients, November 2023; 15(15), 3447

3. Isidor MS, Dong W, Servin-Uribe RI, Villarroel J, Altıntaş A, Ayala-Sumuano JT, Varela-Echavarría A, Barrès R, Stephanopoulos G, Macotela Y, Emanuelli B., Insulin resistance rewires the metabolic gene program and glucose utilization in human white adipocytes., International Journal of Obesity, March 2022; 46(3), 535-543

4. Rodriguez-López LA, Torre-Villalvazo I, Aleman-Escondrillas G, Flores-López A, Guevara-Cruz M, Sánchez-Tapia M, Torre-Anaya EA, Martínez-López V, Vasquez-Reyes S, Torres-Villalobos GM, Macotela Y, Torres N, Tovar AR., The capacity of differentiation of stromal vascular fraction cells into beige adipocytes is markedly reduced in subjects with overweight/obesity and insulin resistance: effect of genistein., International Journal of Obesity, November 2021; 45(11), 2471-2481

5. Ramirez-Hernandez G, Adan-Castro E, Diaz-Lezama N, Ruiz-Herrera X, Martinez de la Escalera G, Macotela Y*, Clapp C*. *AUTORES DE CORRESPONDENCIA, Global Deletion of the Prolactin Receptor Aggravates Streptozotocin-Induced Diabetes in Mice., Frontieres in Endocrinology (Lausanne), March 2021; 12(619696)

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Publicaciones

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1. Ferreira SRG*, Macotela Y*, Velloso LA, Mori MA. *Igual Contribución., Determinants of obesity in Latin America., Nature Metabolism, March 2024; 6(3), 409-432

2. Luzardo-Ocampo I, Ocampo-Ruiz AL, Dena-Beltrán JL, Martínez de la Escalera G, Clapp C, Macotela Y*. *Autor de correspondencia., The Diversity of Gut Microbiota at Weaning Is Altered in Prolactin Receptor-Null Mice., Nutrients, November 2023; 15(15), 3447

3. Isidor MS, Dong W, Servin-Uribe RI, Villarroel J, Altıntaş A, Ayala-Sumuano JT, Varela-Echavarría A, Barrès R, Stephanopoulos G, Macotela Y, Emanuelli B., Insulin resistance rewires the metabolic gene program and glucose utilization in human white adipocytes., International Journal of Obesity, March 2022; 46(3), 535-543

4. Rodriguez-López LA, Torre-Villalvazo I, Aleman-Escondrillas G, Flores-López A, Guevara-Cruz M, Sánchez-Tapia M, Torre-Anaya EA, Martínez-López V, Vasquez-Reyes S, Torres-Villalobos GM, Macotela Y, Torres N, Tovar AR., The capacity of differentiation of stromal vascular fraction cells into beige adipocytes is markedly reduced in subjects with overweight/obesity and insulin resistance: effect of genistein., International Journal of Obesity, November 2021; 45(11), 2471-2481

5. Ramirez-Hernandez G, Adan-Castro E, Diaz-Lezama N, Ruiz-Herrera X, Martinez de la Escalera G, Macotela Y*, Clapp C*. *AUTORES DE CORRESPONDENCIA, Global Deletion of the Prolactin Receptor Aggravates Streptozotocin-Induced Diabetes in Mice., Frontieres in Endocrinology (Lausanne), March 2021; 12(619696)

6. Macotela Y, Triebel J, Clapp C., Time for a New Perspective on Prolactin in Metabolism., Trends In Endocrinology And Metabolism, April 2020; 31(4), 276-286

7. Ponce AJ, Galván-Salas T, Lerma-Alvarado RM, Ruiz-Herrera X, Hernández-Cortés T, Valencia-Jiménez R, Cárdenas-Rodríguez LE, Martínez de la Escalera G, Clapp C, Macotela Y., Low prolactin levels are associated with visceral adipocyte hypertrophy and insulin resistance in humans., Endocrine, February 2020; 67(2), 331-343

8. De los Ríos EA, Ruiz-Herrera X, Tinoco-Pantoja V, López-Barrera F, Martínez de la Escalera G, Clapp C, Macotela Y., Impaired prolactin actions mediate altered offspring metabolism induced by maternal high-fat feeding during lactation., The FASEB Journal, June 2018; 32(3457), 3470

9. Moreno-Carranza B, Bravo-Manríquez M, Baez A, Ledesma-Colunga MG, Ruiz-Herrera X, Reyes-Ortega P, de Los Ríos EA, Macotela Y, Martínez de la Escalera G, Clapp C., Prolactin regulates liver growth during postnatal development in mice., AMERICAN JOURNAL OF PHYSIOLOGY: Regulatory, Integrative and Comparative Physiology, June 2018; 314, R902

10. Ruiz-Herrera X, de Los Ríos EA, Díaz JM, Lerma-Alvarado RM, de la Escalera LM, López-Barrera F, Lemini M, Arnold E, de la Escalera GM, Clapp C, Macotela Y., Prolactin Promotes Adipose Tissue Fitness and Insulin Sensitivity in Obese Males., Endocrinology, January 2017; 158(1), 56-68

11. Lemini M, Ruiz-Herrera X, Ledesma-Colunga MG, Díaz-Lezama N, De Los Ríos EA, Lopez-Barrera F, Méndez I, Martinez de la Escalera G, Macotela Y (autor de correspondencia), Clapp C. , Prolactin anterior pituitary expression and circulating levels are reduced in obese and diabetic rats: Role of TGFβ and TNFα., AMERICAN JOURNAL OF PHYSIOLOGY: Regulatory, Integrative and Comparative Physiology, February 2015; 308(9), 792-799

12. S. Ussar, K. Y. Lee, S. N. Dankel, J. Boucher, M-F. Haering, A. Kleinridders, T. Thomou, R. Xue, Y. Macotela, A. M. Cypess, Y-H. Tseng, G. Mellgren, C. R. Kahn, ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes. Sci. Transl. Med. 6, 247ra103 (2014)., ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes., Science Translational Medicine, July 2014; 6(247), 247ra103

13. Macotela Y, El tejido adiposo: protagonista central de la obesidad, Gaceta UNAM-Juriquilla, March 2013; (23), 8-9

14. Dina I Vázquez-Carrillo, Ana Luisa Ocampo-Ruiz, Arelí Báez-Meza, Gabriela Ramírez-Hernández, Elva Adán-Castro, José Fernando García-Rodrigo, José Luis Dena-Beltrán, Ericka A de Los Ríos, Magdalena Karina Sánchez-Martínez, María Georgina Ortiz, Gonzalo Martínez de la Escalera, Carmen Clapp, Yazmín Macotela*, Dopamine D2 receptor antagonist counteracts hyperglycemia and insulin resistance in diet-induced obese male mice, Plos One, April 2024; 19(4), :e0301496

15. Becerril-Campos AA, Ramos-Gómez M, De Los Ríos-Arellano EA, Ocampo-Anguiano PV, González-Gallardo A, Macotela Y, García-Gasca T, Ahumada-Solórzano SM., Bean Leaves Ameliorate Lipotoxicity in Fatty Liver Disease., Nutrients, November 2023; 15(13), 2928

16. Ruiz-Herrera X*, Luzardo-Ocampo I, Martínez de la Escalera G, Clapp C, Macotela Y*. *Autor de correspondencia., Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance., JOVE, November 2023; 192

17. Luzardo-Ocampo I, Dena-Beltrán JL, Ruiz-Herrera X, Ocampo-Ruiz AL, Martínez de la Escalera G, Clapp C, Macotela Y*. *Autor de correspondencia., Obesity-derived alterations in the lactating mammary gland: Focus on prolactin., Molecular and Cellular Endocrinology, January 2023; 559

18. Macotela Y*, Ruiz-Herrera X, Vázquez-Carrillo DI, Ramírez-Hernandez G, Martínez de la Escalera G, Clapp C. *Autor de correspondencia., The beneficial metabolic actions of prolactin., Frontieres in Endocrinology (Lausanne), September 2022; 13

19. Martínez de la Escalera G, Macotela Y, Clapp C., A New Experimental Tool Toward Understanding the Regulation of Human Prolactin Secretion and Functions. , Endocrinology, April 2022; 163(4)

20. Vázquez-Membrillo M, Siqueiros-Márquez L, Núñez FF, Díaz-Lezama N, Adán-Castro E, Ramírez-Hernández G, Adán N, Macotela Y, Martínez de la Escalera G, Clapp C., Prolactin stimulates the vascularisation of the retina in newborn mice under hyperoxia conditions, Journal Of Neuroendocrinology, May 2020; 32(11), e12858

21. Triebel J, Moreno-Vega AI, Vázquez-Membrillo M, Nava G, García-Franco R, López-Star E, Baldivieso-Hurtado O, Ochoa D, Macotela Y, Bertsch T, Martinez de la Escalera G, Clapp C. , High Prolactin Excretion in Patients with Diabetes Mellitus and Impaired Renal Function, Clinical Laboratory, July 2015; 61(7), 709-716

22. Clapp, C., Thebault, S., Macotela, Y., Moreno-Carranza, B., Triebel, J., Martínez de la Escalera, G., Regulation of blood vessels by prolactin and vasoinhibins., Advances In Experimental Medicine And Biology, January 2015; 846, 83-95

23. Londraville RL, Macotela Y, Duff RJ, Easterling MR, Liu Q, Crespi EJ., Comparative endocrinology of leptin: Assessing function in a phylogenetic context., General And Comparative Endocrinology, February 2014

24. Vernochet C, Mourier A, Bezy O, Macotela Y, Boucher J, Rardin MJ, An D, Lee KY, Ilkayeva OR, Zingaretti CM, Emanuelli B, Smyth G, Cinti S, Newgard CB, Gibson BW, Larsson NG, Kahn CR, Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance., Cell metabolism, December 2012; 16(6), 765-76

25. Mori MA, Raghavan P, Thomou T, Boucher J, Robida-Stubbs S, Macotela Y, Russell SJ, Kirkland JL, Blackwell TJ, Kahn CR. , Role of MicroRNA Processing in Adipose Tissue in Stress Defense and Longevity., Cell metabolism, October 2012; 16(3), 336-347

26. Macotela Y, Emanuelli B, Mori M, Schulz T, Gesta S, Tseng Y, Kahn CR., Intrinsic Differences in Adipocyte Precursor Cells from Different White Fat Depots. , Diabetes, July 2012; 61(7), 1691-1699

27. Boucher J, Mori MA, Lee KY, Smyth G, Liew CW, Macotela Y, Rourk M, Bluher M, Russell SJ, Kahn CR. , Impaired thermogenesis and adipose tissue development in mice with fat-specific disruption of insulin and IGF-1 signalling., Nature Communications, June 2012; 3, 902

28. Yazmin Macotela, Brice Emanuelli, Anneli M Bång, Daniel O Espinoza, Jeremie Boucher, Kirk Beebe, Walter Gall and C. Ronald Kahn, Dietary Leucine - an Environmental Modifier of Insulin Resistance Acting on Multiple Levels of Metabolism, Plos One, 2011; (6), e2187

29. Triebel J, Macotela Y, Martinez de la Escalera G, Clapp C., PROLACTIN AND VASOINHIBINS: ENDOGENOUS PLAYERS IN DIABETIC RETINOPATHY, International Union of Biochemistry and Molecular Biology - IUBMB Life, September 2011

30. Gesta S, Bezy O, Mori, M, Macotela, Y, Lee K Kahn CR., The Mesodermal Developmental Gene Tbx15 Impairs Adipocyte Differentiation and Mitochondria Respiration, Proceedings Of The National Academy Of Sciences Of The United States Of America, February 2011; 108(7), 2771-2776

31. Boucher J, Macotela Y, Bezy O, Mori MA, Kriauciunas K, Kahn CR. , A Kinase-Independent Role for Unoccupied Insulin and IGF-1 Receptors in the Control of Apoptosis. , Science Signaling, December 2010; 3(151), ra87 1-10

32. Macotela Y, Boucher J, Tran TT, Kahn CR., Gender and Depot Differences in Adipocyte Insulin Sensitivity and Glucose Metabolism. , Diabetes, 2009; 58, 803-812

33. Emanuelli B, Macotela Y, Boucher J, Kahn CR., SOCS-1 deficiency does not prevent diet-induced insulin resistance., Biochemical And Biophysical Research Communication, 2008; 377, 447-452

34. García C, Aranda J, Arnold E, Thébault S, Macotela Y, López-Casillas F, Mendoza V, Quiroz-Mercado H, Hernández-Montiel HL, Lin SH, de la Escalera GM, Clapp C., Vasoinhibins prevent retinal vasopermeability associated with diabetic retinopathy in rats via protein phosphatase 2A-dependent eNOS inactivation., Journal Of Clinical Investigation, 2008; 118, 2291-2300

35. González C, Parra A, Ramírez-Peredo J, García C, Rivera JC, Macotela Y, Aranda J, Lemini M, Arias J, Ibargüengoitia F, de la Escalera GM, Clapp C., Elevated vasoinhibins may contribute to endothelial cell dysfunction and low birth weight in preeclampsia. , Laboratory Investigation, 2007; 87, 1009-1017

36. Clapp C, Gonzalez C, Macotela Y, Aranda J, Rivera JC, Garcia C, Guzman J, Zamorano M, Vega C, Martin C, Jeziorski MC, Martinez de la Escalera G., Vasoinhibins: A Family of N-Terminal Prolactin Fragments that Inhibit Angiogenesis and Vascular Function., Frontiers Of Hormone Research, 2006; 35, 64-73

37. Macotela Y, Aguilar M, Guzmán-Morales J, Rivera JC, Zermeño C, Lopez-Barrera F, Nava G, Lavalle C, Martinez de la Escalera G and Clapp C., Matrix metalloproteases from chondrocytes generate an antiangiogenic 16kDa prolactin. , Journal Of Cell Science, 2006; 119, 1790-1800

38. Zermeño C, Guzmán-Morales J, Macotela Y, Nava G, Lopez-Barrera F, Kouri JB, Lavalle C, Martinez de la Escalera G and Clapp C., Prolactin inhibits the apoptosis of chondrocytes induced by serum starvation., Journal Of Endocrinology, 2006; 189, R1-R8

39. Montes de Oca P, Macotela Y, Nava G, López-Barrera F, Martínez de la Escalera G, Clapp C., Prolactin stimulates integrin mediated adhesion of circulating mononuclear cells to endothelial cells., Laboratory Investigation, 2005; 85, 633-642

40. Dueñas Z, Rivera JC, Quiróz-Mercado H, Aranda J, Macotela Y, Montes de Oca P, López-Barrera F, Nava G, Guerrero JL, Suarez A, De Regil M, Martinez de la Escalera G, Clapp C., Prolactin in the eye of patients with retinopathy of prematurity: implications for vascular regression., Investigative Ophthalmology & Visual Science, 2004; 45, 2049-2055

41. Corbacho AM*, Macotela Y*, Nava G, Eiserich, JP, Cross CE, Martínez de la Escalera G, Clapp C., Cytokine induction of prolactin receptors mediates prolactin inhibition of nitric oxide synthesis in pulmonary fibroblasts., Febs Letters, 2003; 544, 171-175

42. Macotela Y, Mendoza C, Corbacho AM, Cosío G, Eiserich JP, Zentella A, Martínez de la Escalera G, Clapp C., 16K prolactin induces NF-kB activation in pulmonary fibroblasts., Journal Of Endocrinology, 2002; 175, R13-R18

43. Corbacho A, Macotela Y, Nava G, Torner L, Dueñas Z, Noris G, Morales MA, Martínez de la Escalera G, Clapp C., Human umbilical vein endothelial cells express multiple prolactin isoforms., Journal Of Endocrinology, 2000; 166, 53-62

44. Corbacho AM, Nava G, Eiserich JP, Noris G, Macotela Y, Struman I, Martinez de la Escalera G, Freeman B, Clapp C. , Proteolytic cleavage confers NO synthase inducing activity upon prolactin., Journal Of Biological Chemistry, 2000; 275, 13183-13186

45. Clapp C, López-Gómez FJ, Nava G, Corbacho A, Torner L, Macotela Y, Dueñas Z, Ochoa A, Noris G, Acosta E, Garay E, Martínez de la Escalera G., Expression of prolactin mRNA and of prolactin-like proteins in endothelial cells: evidence for autocrine effects., Journal Of Endocrinology, 1998; 158, 137-144

46. Dominguez V, Gevorkian G, Govezensky T, Rodriguez H, Viveros M, Cocho G, Macotela Y, Masso F, Pacheco M, Estrada JL, Lavalle C, Larralde C., Antigenic Homology of HIV-1 GP41 and human platelet glycoprotein GPIIIa (integrin 3). , Journal of Acquired Immune Deficiency Syndromes, 1998; 17, 385-390

Most Recent Advised Theses

1. SAIRI IZCHEL ROBLES TORRES. (estudiante), COMPARACIÓN DE LOS EFECTOS DEL ANTAGONISTA DEL RECEPTOR DOPAMINÉRGICO D2, SULPIRIDA, EN EL METABOLISMO DE RATONES MACHO Y HEMBRA CON OBESIDAD., Modalidad: Por proyecto de investigación, Maestría en Ciencias (Neurobiología), Maestría, Instituto de Neurobiología, Instituto de Neurobiología, UNAM, Fecha de presentación de examen: 2024-12-13, Macotela Guzmán Yazmín (Director)

2. Ana Luisa Ocampo Ruiz (estudiante), Caracterización de la mielinización en sistema nervioso central durante el desarrollo postnatal en ratones wild type y knockout para el receptor de prolactina., Modalidad: Por proyecto de investigación, Maestría en Ciencias (Neurobiología), Maestría, Instituto de Neurobiología, Instituto de Neurobiología. Universidad Nacional Autónoma de México. Campus UNAM-Juriquilla, Querétaro. México., Fecha de presentación de examen: 2021-08-25, Macotela Guzmán Yazmín (Director)

3. Marco Antonio Dimas Rufino (estudiante), ALTERACIONES EN EL PROCESO DE MIELINIZACIÓN EN LA ETAPA POSTNATAL EN RATONES KNOCKOUT DEL RECEPTOR A PROLACTINA, Modalidad: Por proyecto de investigación, Maestría en Ciencias (Neurobiología), Maestría, Instituto de Neurobiología UNAM-Juriquilla, Instituto de Neurobiología UNAM-Juriquilla, Fecha de presentación de examen: 2019-12-13, Macotela Guzmán Yazmín (Director)

4. Natalia García Orihuela (estudiante), “INFLUENCIA DE LA HORMONA PROLACTINA EN LA RESISTENCIA A INSULINA EN CULTIVOS PRIMARIOS DE ADIPOCITOS DE RATÓN.”, Modalidad: Tesis, Ingeniería en Biotecnología, Licenciatura, Facultad de Química, Universidad Autonoma de Queretaro, Fecha de presentación de examen: 2019-08-09, Macotela Guzmán Yazmín (Director)

5. Viridiana Tinoco Pantoja (estudiante), Los ratones carentes del receptor de prolactina son mas susceptibles a desarrollar hígado graso ante una alimentación materna obesogénica durante la lactancia, Modalidad: Tesis, Licenciatura en Nutrición, Licenciatura, División de Ciencias de la Salud e Ingenierías, Universidad de Guanajuato, Fecha de presentación de examen: 2018-11-12, Macotela Guzmán Yazmín (Director)