Plataforma de Información Curricular

Research Interest

Effect of the electrical stimulation of the hypothalamic paraventricular nuclei (PVN) on the neuronal activity of the trigeminal caudal subnucleus (Sp5C)
Potential analgesic effects of oxytocin in humans
The role of insular cortex (ICx) on the nociceptive modulation and its connection with the hypothalamic paraventricular nuclei (PVN)
The role of supraspinal structures in the spinal long-term potentiation (LTP) induced by electrical stimulation of the sciatic nerve

Most Recent Publications

1. González-Hernández A, Marichal-Cancino BA, MaassenVanDenBrink A, Villalón CM, Serotonergic modulation of neurovascular transmisión: a focus on prejunctional 5-HT receptors/mechanisms, Biomedicines, June 2023; 11(1864), 1-18 online

2. Salinas-Abarca AB, Martínez-Lorenzana G, Condés-Lara M, González-Hernández A, The role of the endocannabinoid 2-arachidonoylglycerol in the in vivo spinal oxytocin-induced antinociception in male rats, Experimental Neurology, May 2023; 363(114383), 1-13 online

3. Córdoba-López G, Martínez-Lorenzana G, Lozano-Cuenca J, Condés-Lara M, González-Hernández A, The differential in vivo contribution of spinal α2A- and α2C-adrenoceptors in tonic and acute evoked nociception in the rat, Frontiers in Pharmacology, December 2022; 13, 1023611 online

4. Salinas-Abarca AB, Vázquez-Cuevas FG, González-Gallardo A, Martínez-Lorenzana G, González-Hernández A, Condés-Lara M, The glial cell's role in antinociceptive differential effects of oxytocin upon female and male rats , European Journal Of Pain, November 2022; 26, 796-810 online

5. Martínez-Lorenzana G, Tirado-Lourdes P, Cifuentes-Díaz C, González-Hernández A, Condés-Lara M, Ultrastructural Evidence for Oxytocin and Oxytocin Receptor at the Spinal Dorsal Horn: Mechanism of Nociception Modulation , Neuroscience, November 2021; 475, 117-126 online

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Publicaciones

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1. González-Hernández A, Marichal-Cancino BA, MaassenVanDenBrink A, Villalón CM, Serotonergic modulation of neurovascular transmisión: a focus on prejunctional 5-HT receptors/mechanisms, Biomedicines, June 2023; 11(1864), 1-18 online

2. Salinas-Abarca AB, Martínez-Lorenzana G, Condés-Lara M, González-Hernández A, The role of the endocannabinoid 2-arachidonoylglycerol in the in vivo spinal oxytocin-induced antinociception in male rats, Experimental Neurology, May 2023; 363(114383), 1-13 online

3. Córdoba-López G, Martínez-Lorenzana G, Lozano-Cuenca J, Condés-Lara M, González-Hernández A, The differential in vivo contribution of spinal α2A- and α2C-adrenoceptors in tonic and acute evoked nociception in the rat, Frontiers in Pharmacology, December 2022; 13, 1023611 online

4. Salinas-Abarca AB, Vázquez-Cuevas FG, González-Gallardo A, Martínez-Lorenzana G, González-Hernández A, Condés-Lara M, The glial cell's role in antinociceptive differential effects of oxytocin upon female and male rats , European Journal Of Pain, November 2022; 26, 796-810 online

5. Martínez-Lorenzana G, Tirado-Lourdes P, Cifuentes-Díaz C, González-Hernández A, Condés-Lara M, Ultrastructural Evidence for Oxytocin and Oxytocin Receptor at the Spinal Dorsal Horn: Mechanism of Nociception Modulation , Neuroscience, November 2021; 475, 117-126 online

6. González-Hernández A, Marichal-Cancino BA, Villalón CM, The impact of CGRPergic monoclonal antibodies on prophylactic antimigraine therapy and potential adverse events, Expert Opinion on Drug Metabolism & Toxicology, October 2021; 17(10), 12231235 online

7. Marichal-Cancino BA, González-Hernández A, Guerrero-Alba R, Medina Santillán R, Villalón CM, A critical review of the neurovascular nature of migraine and the main mechanisms of action of prophylactic antimigraine medications , Expert Review of Neurotherapeutics, September 2021; 21(9), 1035-1050 online

8. Espinosa de los Monteros Zúñiga A, Martínez-Lorenzana G, Condés-Lara, González-Hernández A, In vivo dissection of two intracellular pathways involved in the spinal oxytocin-induced antinociception in the rat, ACS Chemical Neuroscience, August 2021; 12(16), 3140-3147 online

9. Gamal-Eltrabily M, Martínez-Lorenzana G, González-Hernández A, Condés-Lara M, Cortical modulation of nociception, Neuroscience, March 2021; 458, 256-270 online

10. Martínez-Lorenzana G, Gamal-Eltrabily, Tello-García IA, Martínez-Torres A, Becerra-González M, González-Hernández A, Condés-Lara, CLARITY with neuronal tracing and immunofluorescence to study the somatosensory system in rats, Journal of Neuroscience Methods, February 2021; 350, 109048 online

11. González-Hernández A, Condés-Lara M, García-Boll E, Villalón CM, An outlook on the trigeminovascular mechanisms of action and side effects concerns of some potential neuropeptidergic antimigraine therapies, Expert Opinion on Drug Metabolism & Toxicology, January 2021; 17, 179-199 online

12. Espinosa de los Monteros-Zúñiga A, Martínez-Lorenzana G, Condés-Lara M, González-Hernández A, Intrathecal oxytocin improves spontaneous behavior and reduces mechanical hypersensitivity in a rat model of postoperative pain, Frontiers in Pharmacology, November 2020; 11(581544), 1-10 online

13. González-Hernández A, Marichal-Cancino BA, García-Boll E, Villalón CM, The locus of action of CGRPergic monoclonal antibodies against migraine: peripheral over central mechanisms, CNS & Neurological Disorders-Drug Targets, November 2020; 19(5), 344-359 online

14. Marichal-Cancino BA, González-Hernández A, Muñoz-Islas E, Villalón CM, Monoaminergic Receptors as Modulators of the Perivascular Sympathetic and Sensory CGRPergic Outflows, Current Neuropharmacology, November 2020; 18(9), 790-808 online

15. Tello-García IA, Pérez-Ortega J, Martínez-Lorenzana G, González-Hernández A, Condés-Lara M, Oxytocin prevents neuronal network pain-related changes on spinal cord dorsal horn in vitro, Cell Calcium, August 2020; 90, 102246 online

16. Gamal-Eltrabily M, Espinosa de los Monteros-Zúñiga A, Manzano-García A, Martínez-Lorenzana G, Condés-Lara M, González-Hernández A, The rostral agranular insular cortex, a new site of oxytocin to induce antinociception, Journal Of Neuroscience, July 2020; 40, 5668-5679 online

17. Marichal-Cancino BA, González-Hernández A, MaassenVanDenBrink A, Ramírez-San Juan E, Villalón CM, Potential Mechanisms Involved in Palmitoylethanolamide-Induced Vasodepressor Effects in Rats, Journal of Vascular Research, May 2020; 57, 152-163 online

18. García-Boll E, Martínez-Lorenzana G, Condés-Lara M, González-Hernández A, Inhibition of nociceptive dural input to the trigeminocervical complex by activation of oxytocin receptors, Experimental Neurology, January 2020; 323, 113079 online

19. González-Hernández A, Espinosa de los Monteros-Zuñiga A, Martínez-Lorenzana G, Condés-Lara M, Recurrent antinociception induced by intrathecal or peripheral oxytocin in a neuropathic pain rat model, Experimental Brain Research, November 2019; 237, 2995-3010 online

20. González-Hernández A, Marichal-Cancino BA, Lozano-Cuenca J, MaassenVanDenBrink A, Villalón CM, Functional Characterization of the Prejunctional Receptors Mediating the Inhibition by Ergotamine of the Rat Perivascular Sensory Peptidergic Drive, ACS Chemical Neuroscience, October 2019; 10, 3173-3182 online

21. Zayas-González H, González-Hernández A, Manzano-García A, Hernández-Rivero D, García-Cuevas MA, Granados-Mortera JC, Vaca-Aguirre L, Flores-Fierro S, Condés-Lara M, Effect of local infiltration with oxytocin on hemodynamic response to surgical incision and postoperative pain in patients having open laparoscopic surgery under general anesthesia, European Journal Of Pain, October 2019; 23, 1519-1526 online

22. Béjar-Alonso J, Martínez-Lorenzana G, González-Hernández A, Cortes U, Condés-Lara M, Recurrent inhibition in the cerebral cortex, Neuroscience Letters, January 2019; 696, 20-27 online

23. Guerrero-Alba R, Barragán-Iglesias P, González-Hernández A, Valdez-Morales EE, Granados-Soto V, Condés-Lara M, Rodríguez MG, Marichal-Cancino BA, Some Prospective Alternatives for Treating Pain: The Endocannabinoid System and Its Putative Receptors GPR18 and GPR55, Frontiers in Pharmacology, January 2019; 9, 1496 online

24. González-Hernández A, Charlet A, Oxytocin, GABA and TRPV1, the analgesic triad?, Frontiers in Molecular Neuroscience, November 2018; 11(398), 4 online

25. González-Hernández A, Lozano-Cuenca J, Marichal-Cancino BA, MaassenVanDenBrink A, Villalón CM, Dihydroergotamine inhibits the vasodepressor sensory CGRPergic outflow by prejunctional activation of α2-adrenoceptors and 5-HT1 receptors, Journal of Headache and Pain, November 2018; 19(40), 10 online

26. Manzano-García A, González-Hernández A, Martínez-Lorenzana G, Tello-García IA, Condés-Lara M, The role of peripheral V1A and oxytocin receptors on the subcutaneous vasopressin antinociceptive effects, European Journal Of Pain, November 2018; 22(3), 511-526 online

27. Cóndes-Lara M, Martínez-Lorenzana G, Rojas-Piloni G, Tello-García I, Manzano García A, Rubio-Beltrán E, González-Hernández A, Axons of individual dorsal horn neurons bifurcated to project in both the anterolateral and postsynaptic dorsal column systems, Neuroscience, October 2018; 371, 176-190 online

28. García-Boll E, Martínez-Lorenzana G, Condés-Lara M, González-Hernández A, Oxytocin inhibits the rat medullary dorsal horn Sp5c/C1 nociceptive transmission through OT but not V1A receptors, Neuropharmacology, October 2018; 129, 109-117 online

29. González-Hernández A, Marichal-Cancino BA, MaassenVanDenBrink A, Villalón CM, Side effects associated with current and prospective antimigraine pharmacotherapies, Expert Opinion on Drug Metabolism & Toxicology, October 2018; 14(1), 25-41 online

30. Gamal-Eltrabily M, Márquez-Morales C, Martínez-Lorenzana G, González-Hernández A, Condés-Lara M, Peptidergic nature of nociception-related projections from the hypothalamic paraventricular nucleus to the dorsal horn of the spinal cord, Neuroscience Letters, August 2018; 685, 124-130 online

31. Escárcega-González CE, González-Hernández A, Villalón CM, Gerardo-Rodríguez M, Marichal-Cancino BA, β-Adrenoceptor Blockade for Infantile Hemangioma Therapy: Do β3-Adrenoceptors Play a Role?, Journal of Vascular Research, June 2018; 55(3), 159-168 online

32. González-Hernández A, Manzano-García A de J, Martínez-Lorenzana G, Tello-García IA, Carranza M, Arámburo C, Condés-Lara, Peripheral oxytocin receptors inhibits the nociceptive activity of spinal dorsal horn wide dynamic range neurons, Pain, October 2017; 158(11), 2117-2128 online

33. Lozano-Cuenca J, González-Hernández A, López-Canales O, Villagrana-Zesati J, Rodríguez-Choreño J, Morin-Zaragoza R, Castillo-Henkel E, López-Canales J, Possible mechanisms involved in the vasorelaxant effect produced by clobenzorex in aortic segments of rat, Brazilian Journal of Medical and Biological Research, September 2017; 50(9), e5765 online

34. González-Hernández A, Marichal-Cancino BA, Lozano-Cuenca J, López-Canalez JS, Muñoz-Islas E, Ramírez-Rosas MB, Villalón CM, Heteroreceptors Modulating CGRP Release at Neurovascular Junction: Potential Therapeutic Implications on Some Vascular-Related Diseases, BioMed Research International, December 2016; 2016(2056786), 17 online

35. Godínez-Chaparro B, Martínez-Lorenzana G, Rodríguez-Jiménez J, Manzano-García A, Rojas-Piloni G, Condés-Lara M, González-Hernández A, The potential role of serotonergic mechanisms in the spinal oxytocin-induced antinociception, Neuropeptides, November 2016; 60, 51-60 online

36. Condés-Lara M, Zayas-González H, Manzano-García A, González-Hernández A, Response to Letter to the Editor by Eisenach & Yaksh on "Successful Pain Management with Epidural Oxytocin", CNS Neuroscience & Therapeutics, October 2016; 22(10), 867-868 online

37. Condés-Lara M, Zayas-González H, Manzano-García A, Córdova-Quiroz E, Granados-Mortera J, García-Cuevas M, Morales-Gómez J, González-Hernández A, Successful Pain Management with Epidural Oxytocin, CNS Neuroscience & Therapeutics, June 2016; 22(6), 532-534 online

38. Muñoz-Islas E, González-Hernández A, Lozano-Cuenca J, Ramírez-Rosas MB, Medina-Santillán R, Centurión D, MaassenVanDenBrink A, Villalón CM, Inhibitory effect of chronic oral treatment with fluoxetine on capsaicin-induced external carotid vasodilatation in anaesthetised dogs, Cephalalgia, October 2015; 35(12), 1041-1053 online

39. Condés-Lara M, Martínez-Lorenzana G, Rubio-Beltrán E, Rodríguez-Jiménez J, Rojas-Piloni G, González-Hernández A, Hypothalamic paraventricular nucleus stimulation enhances c-Fos expression in spinal and supraspinal structures related to pain modulation, Neuroscience Research, September 2015; 98, 59-63 online

40. González-Hernández A, Martínez-Lorenzana G, Rodríguez-Jiménez J, Rojas-Piloni G, Condés-Lara M, Intracisternal injection of palmitoylethanolamide inhibits the peripheral nociceptive evoked responses of dorsal horn wide dynamic range neurons, Journal Of Neural Transmission, March 2015; 122(3), 369-374 online

41. González-Hernández A, Rojas-Piloni G, Condés-Lara M, Oxytocin and analgesia: future trends, Trends in Pharmacological Sciences, November 2014; 35(11), 549-551 online

42. Manrique-Maldonado G, González-Hernández A, Altamirano-Espinoza AH, Marichal-Cancino BA, Ruiz-Salinas I, Villalón CM., The role of pre-junctional D2 -like receptors mediating quinpirole-induced inhibition of the vasodepressor sensory CGRPergic out-flow in pithed rats, Basic & Clinical Pharmacology & Toxicology, February 2014; 114(2), 174-180 online

43. González-Hernández A, Condés-Lara M, The multi-target drug approach in migraine treatment: the new challenge to conquer, Headache: The Journal of Head and Face Pain, January 2014; 54(1), 197-199 online

44. Marichal-Cancino BA, Manrique-Maldonado G, Altamirano-Espinoza AH, Ruiz-Salinas II, González-Hernández A, Maassenvandenbrink A, Villalón CM, Analysis of anandamide- and lysophosphatidylinositol-induced inhibition of the vasopressor responses induced by sympathetic stimulation or noradrenaline in pithed rats, European Journal Of Pharmacology, December 2013; 721(1-3), 168-177 online

45. Altamirano-Espinoza AH, González-Hernández A, Manrique-Maldonado G, Marichal-Cancino BA, Ruíz-Salinas I, Villalón CM, The role of dopamine D2, but not D3 or D4 receptor subtypes in quinpirole-induced inhibition of the cardioaccelerator sympathetic outflow in pithed rats, British Journal Of Pharmacology, November 2013; 170(5), 1102-1111 online

46. Ruiz-Salinas I, González-Hernández A, Manrique-Maldonado G, Marichal-Cancino BA, Altamirano-Espinoza AH, Villalón CM, Predominant role of the dopamine D3 receptor subtype for mediating the quinpirole-induced inhibition of the vasopressor sympathetic outflow in pithed rats, Naunyn-Schmiedeberg's Archives of Pharmacology, October 2013; 386(5), 393-403 online

47. Mena F, González-Hernández A, Navarro N, Castilla A, Morales T, Rojas-Piloni G, Martínez-Lorenzana G, Condés-Lara M, Prolactin fractions from lactating rats elicit effects upon sensory spinal cord cells of male rats, Neuroscience, September 2013; 248, 552-561 online

48. González-Hernández A, Martinez-Lorenzana G, Rojas-Piloni G, Rodríguez-Jiménez J, Hernández-Linares YG, Villanueva L, Condés-Lara M, Spinal LTP induced by sciatic nerve electrical stimulation enhances thalamic nociceptive responses of the triangular posterior nucleus, Neuroscience, March 2013; 234, 552-561 online

49. Marichal-Cancino BA, González-Hernández A, Manrique-Maldonado G, Ruiz-Salinas II, Altamirano-Espinoza AH, Maassenvandenbrink A, Villalón CM, Intrathecal dihydroergotamine inhibits capsaicin-induced vasodilatation in the canine external carotid circulation via GR127935- and rauwolscine-sensitive receptors, European Journal Of Pharmacology, December 2012; 692(1-3), 69-77 online

50. Villalón CM, Galicia-Carreón J, González-Hernández A, Marichal-Cancino BA, Manrique-Maldonado G, Centurión D, Pharmacological evidence that spinal α(2C)- and, to a lesser extent, α(2A)-adrenoceptors inhibit capsaicin-induced vasodilatation in the canine external carotid circulation, European Journal Of Pharmacology, May 2012; 683(1-3), 204-210 online

51. González-Hernández A, Manrique-Maldonado G, Lozano-Cuenca J, Muñoz-Islas E, Centurión D, Maassen VanDenBrink A, Villalón CM, The 5-HT(1) receptors inhibiting the rat vasodepressor sensory CGRPergic outflow: further involvement of 5-HT(1F), but not 5-HT(1A) or 5-HT(1D), subtypes, European Journal Of Pharmacology, June 2011; 659(2-3), 233 online

52. Manrique-Maldonado G, González-Hernández A, Marichal-Cancino BA, Villamil-Hernández MT, del Mercado OA, Centurión D, Villalón CM, The dopamine receptors mediating inhibition of the sympathetic vasopressor outflow in pithed rats: pharmacological correlation with the D(2) -like type, Basic & Clinical Pharmacology & Toxicology, May 2011; 109(6), 506-512 online

53. Ramírez-Rosas MB, Cobos-Puc LE, Muñoz-Islas E, González-Hernández A, Sánchez-López A, Villalón CM, Maassenvandenbrink A, Centurión D, Pharmacological evidence that Ca²+ channels and, to a lesser extent, K+ channels mediate the relaxation of testosterone in the canine basilar artery, Steroids, May 2011; 76(4), 409-415 online

54. González-Hernández A, Muñoz-Islas E, Lozano-Cuenca J, Ramírez-Rosas MB, Sánchez-López A, Centurión D, Ramírez-San Juan E, Villalón CM, Activation of 5-HT1B receptors inhibits the vasodepressor sensory CGRPergic outflow in pithed rats, European Journal Of Pharmacology, July 2010; 637(1-3), 131-137 online

55. Muñoz-Islas E, Lozano-Cuenca J, González-Hernández A, Ramírez-Rosas MB, Sánchez-López A, Centurión D, Maassenvandenbrink A, Villalón CM, Spinal sumatriptan inhibits capsaicin-induced canine external carotid vasodilatation via 5-HT1B rather than 5-HT1D receptors, European Journal Of Pharmacology, August 2009; 615(1-3), 133-138 online

56. Lozano-Cuenca J, Muñoz-Islas E, González-Hernández A, Centurión D, Cobos-Puc LE, Sánchez-López A, Pertz HH, Villalón CM., Pharmacological profile of the inhibition by dihydroergotamine and methysergide on the cardioaccelerator sympathetic outflow in pithed rats., European Journal Of Pharmacology, June 2009; 612(1-3), 80-86 online

57. Lozano-Cuenca J, González-Hernández A, Muñoz-Islas E, Sánchez-López A, Centurión D, Cobos-Puc LE, Villalón CM, Effect of some acute and prophylactic antimigraine drugs on the vasodepressor sensory CGRPergic outflow in pithed rats, Life Sciences, January 2009; 84(5-6), 125-132 online

Most Recent Advised Theses

1. Antonio Espinosa de los Monteros Zúñiga (estudiante), Estudio del efecto antinociceptivo de la administración espinal de oxitocina en modelos de dolor persistente y su posible mecanismo de acción intracelular en la rata, Modalidad: Tesis, Doctorado en Ciencias Biomédicas, Doctorado, Instituto de Neurobiología UNAM-Juriquilla, Instituto de Neurobiología UNAM-Juriquilla, Fecha de presentación de examen: 2022-02-02, González Hernández Abimael (Director)

2. Amairani Ruiz Díaz (estudiante), Análisis farmacológico del efecto de la oxitocina sobre la neurotransmisión vascular CGRPérgica en la rata descerebrada y desmedulada (co-dirección), Modalidad: Tesis, Maestría en ciencias (Neurofarmacología y Terapeútica Experimental), Maestría, Departamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados del I.P.N., Fecha de presentación de examen: 2021-12-15, González Hernández Abimael (Director)

3. Mohammed Gamal Mohammed ElSebaey ElTrabily (estudiante), Estudio de la conexión anatomo-funcional oxitocinérgica entre el núcleo paraventricular del hipotálamo y la corteza insular agranular rostral y su función en la nocicepción., Modalidad: Tesis, Doctorado en Ciencias Biomédicas, Doctorado, Instituto de Neurobiología UNAM-Juriquilla, Instituto de Neurobiología UNAM-Juriquilla, Fecha de presentación de examen: 2021-12-02, González Hernández Abimael (Director)

4. Gustavo López Córdoba (estudiante), Caracterización farmacológica de los subtipos de receptores α2-adrenérgicos espinales que modulan la nocicepción en la rata: análisis conductual y electrofisiológico., Modalidad: Por proyecto de investigación, Maestría en Ciencias (Neurobiología), Maestría, Instituto de Neurobiología, Instituto de Neurobiología UNAM-Juriquilla, Fecha de presentación de examen: 2019-09-19, González Hernández Abimael (Director)

5. José Enrique García Boll (estudiante), Efecto de la oxitocina sobre la transmisión nociceptiva en el complejo trigemino cervical de la rata: papel de los receptores de oxitocina y vasopresina 1A, Modalidad: Por proyecto de investigación, Maestría en Neurobiología, Maestría, Instituto de Neurobiología UNAM-Juriquilla, INB-UNAM, Instituto de Neurobiología UNAM-Juriquilla, Fecha de presentación de examen: 2018-06-12, González Hernández Abimael (Director)