Plataforma de Información Curricular

Research Interest

Hormonal regulation of brain neurovascular unit in diabetes.

Most Recent Publications

1. Macías F, Ulloa M, Clapp C, Martínez de la Escalera G, Arnold E. , Prolactin protects hippocampal neurons against H2O2-induced neurotoxicity by suppressing BAX and NOX4 via the NF-κB signaling pathway. , Plos One, November 2024; 19(11), e0313328

2. Castillo X*., Ortíz G*., Arnold E*§., Wu Z., Tovar y Romo LB., Clapp C., Martínez de la Escalera G§. , The influence of the prolactin/vasoinhibin axis on post-stroke lesion volume, astrogliosis, and survival. , Journal Of Neuroendocrinology, May 2024; 36(10), e13415

3. Ulloa M, Macías F, Clapp C, Martínez de la Escalera G, Arnold E. , Prolactin is an endogenous antioxidant factor in astrocytes that limits oxidative stress-induced astrocytic cell death via the STAT3/NRF2 signaling pathway., Neurochemical Research, May 2024; 49, 1879-1901

4. Pamela Reyes-Ortega, Alejandra Rodríguez-Arzate, Ramsés Noguez-Imm, Edith Arnold, and Stéphanie C. Thébault, Contribution of chemical and electrical transmission to the low delta-like intrinsic retinal oscillation in mice: a role for day-light activated neuromodulators, European Journal Of Pharmacology, April 2024; 968, 176384

5. Miriam Ulloa, Fernando Macías, Gonzalo Martínez de la Escalera, Edith Arnold., Acciones del peróxido de hidrógeno (H2O2) como señalizador redox y como agente de estrés oxidante en la diabetes mellitus., Tip Revista Especializada en Ciencias Quimico-Biológicas, November 2023; 26, 1-10

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Publicaciones

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1. Macías F, Ulloa M, Clapp C, Martínez de la Escalera G, Arnold E. , Prolactin protects hippocampal neurons against H2O2-induced neurotoxicity by suppressing BAX and NOX4 via the NF-κB signaling pathway. , Plos One, November 2024; 19(11), e0313328

2. Castillo X*., Ortíz G*., Arnold E*§., Wu Z., Tovar y Romo LB., Clapp C., Martínez de la Escalera G§. , The influence of the prolactin/vasoinhibin axis on post-stroke lesion volume, astrogliosis, and survival. , Journal Of Neuroendocrinology, May 2024; 36(10), e13415

3. Ulloa M, Macías F, Clapp C, Martínez de la Escalera G, Arnold E. , Prolactin is an endogenous antioxidant factor in astrocytes that limits oxidative stress-induced astrocytic cell death via the STAT3/NRF2 signaling pathway., Neurochemical Research, May 2024; 49, 1879-1901

4. Pamela Reyes-Ortega, Alejandra Rodríguez-Arzate, Ramsés Noguez-Imm, Edith Arnold, and Stéphanie C. Thébault, Contribution of chemical and electrical transmission to the low delta-like intrinsic retinal oscillation in mice: a role for day-light activated neuromodulators, European Journal Of Pharmacology, April 2024; 968, 176384

5. Miriam Ulloa, Fernando Macías, Gonzalo Martínez de la Escalera, Edith Arnold., Acciones del peróxido de hidrógeno (H2O2) como señalizador redox y como agente de estrés oxidante en la diabetes mellitus., Tip Revista Especializada en Ciencias Quimico-Biológicas, November 2023; 26, 1-10

6. Ruggiero C, Altieri B, Arnold E, Siqueiros-Marquez L, Doghman-Bouguerra M, Detomas M, Durand N, Jarjat M, Chatonnet F, Fassnacht M, Deutschbein T, Clapp C, Lalli E. , Analysis of mouse adrenal gland links prolactin signaling and adrenal-specific super-enhancers to human endocrine disorders. , Clinical and Translational Medicine, November 2021; 11, e630

7. González-Luna, I. A., Juárez-Tapia, C., Aguilar-Vázquez, A., Arnold, E., Díaz-Cintra, S., Miranda-Anaya, M., & Díaz-Muñoz, M., Changes in 24 h Rhythmicity of Spontaneous Locomotor Activity in the Triple Transgenic Mouse for Alzheimer’s Disease (3xTg-AD) in a Jet Lag Protocol: Correlations with Retinal Sensitivity., Journal of Circadian Rhythms, January 2021; 19(1), 1-15

8. Aroña, R.M., Arnold, E., Macías, F., López-Casillas, F., Clapp, C., Martínez de la Escalera, G. , Vasoinhibin generation and effect on neuronal apoptosis in the hippocampus of late mouse embryos. , AMERICAN JOURNAL OF PHYSIOLOGY: Regulatory, Integrative and Comparative Physiology, April 2020; 318(4), R760-771

9. Arnold, E., Thebault, S., Aroña, R.M., Martínez de la Escalera, G., Clapp, C. , Prolactin mitigates deficiencies of retinal function associated with aging. , Neurobiology of Aging, January 2020; 85, 38-48

10. Melo, Z., Castillo, X., Moreno-Carranza, B., Ledesma-Colunga, M.G., López-Casillas, F., Ruíz-Herrera, X., Clapp, C., Martínez de la Escalera, G. , Vasoinhibin suppresses nerve growth factor-induced differentiation and survival of PC12 pheochromocytoma cells. , Neuroendocrinology, August 2019; 109(2), 152-164

11. Castillo, X., Melo, Z., Varela-Echevarría, A., Tamáriz, E., Aroña, R.M., Arnold, E., Clapp, C., Martínez de la Escalera, G. , Vasoinhibins suppresses the ability of NGF and VEGF to stimulate neurite growth in rat primary sensory neurons. , Neuroendocrinology, March 2018; 106(3), 221-233

12. Ruiz-Herrera X, de Los Ríos EA, Díaz JM, Lerma-Alvarado RM, de la Escalera LM, López-Barrera F, Lemini M, Arnold E, de la Escalera GM, Clapp C, Macotela Y., Prolactin Promotes Adipose Tissue Fitness and Insulin Sensitivity in Obese Males., Endocrinology, January 2017; 158(1), 56-68

13. Kong D, Gong L, Arnold E, Shanmugam S, Fort PE, Gardner TW, Abcouwer SF., Insulin-like growth factor 1 rescues R28 retinal neurons from apoptotic death through ERK-mediated BimEL phosphorylation independent of Akt., Experimental Eye Research, October 2016; 151, 82-95

14. Meléndez García R*, Arredondo Zamarripa R*, Arnold E* (*, equal contribution), Ruiz-Herrera X, Noguez Imm R, Baeza Cruz G, Adán N, Binart N, Riesgo-Escovar N, Goffin V, Ordaz B, Peña-Ortega F, Martínez-Torres A, Clapp C, and Thebault S, Prolactin protects retinal pigment epithelium by inhibiting SIRT2-dependent cell death, EBioMedicine, April 2016; 7, 35-49

15. Díaz-Lezama N, Wu Z, Adán-Castro E, Arnold E, Vázquez-Membrillo M, Arredondo-Zamarripa D, Ledesma-Colunga MG, Moreno-Carranza B, Martinez de la Escalera G, Colosi P, Clapp C. , Diabetes enhances the efficacy of AAV2 vectors in the retina: therapeutic effect of AAV2 encoding vasoinhibin and soluble VEGF receptor 1, Laboratory Investigation, November 2015, 1-13

16. Arredondo, D., Díaz-Lezama, N., Meléndez, R., Chávez Balderas, J., Adán, N., Ledesma-Colunga, M.G., Arnold, E., Clapp, C., Thebault, S. , Vasoinhibins regulate the inner and outer blood-retinal barrier and limit retinal oxidative stress, Frontiers in Cellular Neuroscience, October 2014

17. Arnold, E., Thebault, S., Baeza-Cruz, G., Quintanar-Stephano, A., Condés-Lara, M., Rojas-Piloni, G., Binart, N., Martínez de la Escalera, G., Clapp, C., The hormone prolactin is a novel endogenous trophic factor able to regulate reactive glia and to limit retinal degeneration. , Journal Of Neuroscience, January 2014; 34(5), 1868-1878

18. Ramírez, M., Wu, Z., Moreno-Carranza, B., Jeziorski, M.C., Arnold, E., Díaz-Lezama, N., Martínez de la Escalera, G., Colosi, P., Clapp, C. , Vasoinhibin gene transfer by Adeno-Associated Virus type 2 protects against VEGF- and diabetes-induced retinal vasopermeability. , Investigative Ophthalmology & Visual Science, November 2011; 52(11), 8944-8950

19. Arnold E, Rivera JC, Thebault S, Moreno-Páramo D, Quiroz-Mercado H, Quintanar-Stéphano A, Binart N, Martínez de la Escalera G, Clapp C. , High levels of serum prolactin protect against diabetic retinopathy by increasing ocular vasoinhibins. , Diabetes, December 2010; 59(12), 3192-3197

20. Cruz-Soto ME, Cosío G, Jeziorski MC, Vargas-Barroso V, Aguilar MB, Cárabez A, Berger P, Saftig P, Arnold E, Thebault S, Martínez de la Escalera G, Clapp C, Cathepsin D is the primary protease for the generation of adenohypophyseal vasoinhibins: cleavage occurs within the prolactin secretory granules, Endocrinology, December 2009; 150(12), 5446-54

21. Melo, A.I., Pérez-Ledezma, M., Clapp, C., Rivera, J.C., Fleming, A.S., Arnold, E. , Effects of prolactin deficiency during the early postnatal period on the development of maternal behavior in female rats: Mother’s milk makes the difference. , Hormones And Behavior, January 2009; 59(1), 281-291

22. Clapp C, Thebault S, Arnold E, García C, Rivera JC, Martínez de la Escalera G., Vasoinhibins: Novel inhibitors of ocular angiogenesis, American Journal Of Physiology, Endocrinology And Metabolism, October 2008; 295(4), 772-778

23. García, C., Aranda, J., Arnold, E., Thebault, S., Macotela, J., López-Casillas, F., Mendoza, V., Quiroz-Mercado, H., Lin, S.H., Martínez de la Escalera, G., Clapp, C., Vasoinhibins prevent increased retinal vasopermeability associated with diabetic retinopathy via protein phosphatase 2A-dependent eNOS inactivation, Journal Of Clinical Investigation, June 2008; 118(6), 2291-2300

24. Moreno-Páramo, D., Rivera, J.C., Aranda, J., Salazar, N., Arnold, E., Quiróz-Mercado, H., Martínez de la Escalera, G., Clapp, C., RETINOPATIA DIABETICA Y VASOINHIBINAS., Revista de Investigacion Clinica, January 2007; 19(0), 290-297

Most Recent Advised Theses

1. Paulette Heredia Mejía (estudiante), Análisis del efecto de la prolactina en la respuesta inflamatoria de los astrocitos en condiciones de estrés oxidante., Modalidad: Tesis, Químico Farmacéutico Biotecnólogo, Licenciatura, Universidad del Valle de México Campus Querétaro, Universidad del Valle de México, Fecha de presentación de examen: 2024-11-11, Arnold Hernández Edith (Director)

2. Miriam Nayely Ulloa Zamudio (estudiante), El papel protector de la prolactina sobre el daño inducido por un estrés oxidativo en astrocitos de rata., Modalidad: Por proyecto de investigación, Maestría en Ciencias (Neurobiología), Maestría, Instituto de Neurobiología UNAM-Juriquilla, INB-UNAM, Instituto de Neurobiología UNAM-Juriquilla, Fecha de presentación de examen: 2018-11-23, Arnold Hernández Edith (Director)

3. Elva Hortencia Adán Castro, (estudiante), Análisis del efecto de la hiperprolactinemia inducida por sulpirida sobre la retinopatía diabética experimental., Modalidad: Por proyecto de investigación, Maestría en Ciencias (Neurobiolgía), UNAM. , Maestría, Instituto de Neurobiología UNAM-Juriquilla, INB-UNAM, Instituto de Neurobiología UNAM-Juriquilla, Fecha de presentación de examen: 2017-07-27, Clapp Jiménez L María del Carmen (Director), Arnold Hernández Edith (Director)

4. Fernando Macías Prado (estudiante), Regulación del sistema prolactina/vasoinhibinas en astrocitos hipocampales a lo largo del desarrollo., Modalidad: Tesis, Biología, Licenciatura, Escuela de Biología, Benemérita Universidad Autónoma de Puebla, Fecha de presentación de examen: 2017-06-12, Arnold Hernández Edith (Director)

5. Karla Gabriela Ortiz Gómez (estudiante), Análisis del efecto de la prolactina (PRL) sobre la supervivencia de los astrocitos corticales sometidos a un estrés oxidativo, Modalidad: Tesis, Químico Farmacéutico Biólogo , Licenciatura, Facultad de Química, Universidad Autonoma de Queretaro, Fecha de presentación de examen: 2016-08-11, Arnold Hernández Edith (Director)