Plataforma de Información Curricular

Research Interest

Hormonal regulation of brain neurovascular unit in diabetes.

Most Recent Publications

1. Adán-Castro E., Zamora M., Granados-Carrasco D., Siqueiros-Márquez L., García-Rodrigo J.F., Macías F., Bertsch T., Triebel J., Arnold E., Martínez de la Escalera G., Robles J.P., Clapp C. , Topical ophthalmic administration of the antiangiogenic peptide VIAN-c4551 protects against experimental diabetic macular edema., Scientific Reports, July 2025; 15, 26767

2. Macías F, Ulloa M, Clapp C, Martínez de la Escalera G, Arnold E. , Prolactin protects hippocampal neurons against H2O2-induced neurotoxicity by suppressing BAX and NOX4 via the NF-κB signaling pathway. , Plos One, November 2024; 19(11), e0313328

3. Castillo X*., Ortíz G*., Arnold E*§., Wu Z., Tovar y Romo LB., Clapp C., Martínez de la Escalera G§. , The influence of the prolactin/vasoinhibin axis on post-stroke lesion volume, astrogliosis, and survival. , Journal Of Neuroendocrinology, May 2024; 36(10), e13415

4. Ulloa M, Macías F, Clapp C, Martínez de la Escalera G, Arnold E. , Prolactin is an endogenous antioxidant factor in astrocytes that limits oxidative stress-induced astrocytic cell death via the STAT3/NRF2 signaling pathway., Neurochemical Research, May 2024; 49, 1879-1901

5. Pamela Reyes-Ortega, Alejandra Rodríguez-Arzate, Ramsés Noguez-Imm, Edith Arnold, and Stéphanie C. Thébault, Contribution of chemical and electrical transmission to the low delta-like intrinsic retinal oscillation in mice: a role for day-light activated neuromodulators, European Journal Of Pharmacology, April 2024; 968, 176384

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Publicaciones

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1. Adán-Castro E., Zamora M., Granados-Carrasco D., Siqueiros-Márquez L., García-Rodrigo J.F., Macías F., Bertsch T., Triebel J., Arnold E., Martínez de la Escalera G., Robles J.P., Clapp C. , Topical ophthalmic administration of the antiangiogenic peptide VIAN-c4551 protects against experimental diabetic macular edema., Scientific Reports, July 2025; 15, 26767

2. Macías F, Ulloa M, Clapp C, Martínez de la Escalera G, Arnold E. , Prolactin protects hippocampal neurons against H2O2-induced neurotoxicity by suppressing BAX and NOX4 via the NF-κB signaling pathway. , Plos One, November 2024; 19(11), e0313328

3. Castillo X*., Ortíz G*., Arnold E*§., Wu Z., Tovar y Romo LB., Clapp C., Martínez de la Escalera G§. , The influence of the prolactin/vasoinhibin axis on post-stroke lesion volume, astrogliosis, and survival. , Journal Of Neuroendocrinology, May 2024; 36(10), e13415

4. Ulloa M, Macías F, Clapp C, Martínez de la Escalera G, Arnold E. , Prolactin is an endogenous antioxidant factor in astrocytes that limits oxidative stress-induced astrocytic cell death via the STAT3/NRF2 signaling pathway., Neurochemical Research, May 2024; 49, 1879-1901

5. Pamela Reyes-Ortega, Alejandra Rodríguez-Arzate, Ramsés Noguez-Imm, Edith Arnold, and Stéphanie C. Thébault, Contribution of chemical and electrical transmission to the low delta-like intrinsic retinal oscillation in mice: a role for day-light activated neuromodulators, European Journal Of Pharmacology, April 2024; 968, 176384

6. Miriam Ulloa, Fernando Macías, Gonzalo Martínez de la Escalera, Edith Arnold., Acciones del peróxido de hidrógeno (H2O2) como señalizador redox y como agente de estrés oxidante en la diabetes mellitus., Tip Revista Especializada en Ciencias Quimico-Biológicas, November 2023; 26, 1-10

7. Ruggiero C, Altieri B, Arnold E, Siqueiros-Marquez L, Doghman-Bouguerra M, Detomas M, Durand N, Jarjat M, Chatonnet F, Fassnacht M, Deutschbein T, Clapp C, Lalli E. , Analysis of mouse adrenal gland links prolactin signaling and adrenal-specific super-enhancers to human endocrine disorders. , Clinical and Translational Medicine, November 2021; 11, e630

8. González-Luna, I. A., Juárez-Tapia, C., Aguilar-Vázquez, A., Arnold, E., Díaz-Cintra, S., Miranda-Anaya, M., & Díaz-Muñoz, M., Changes in 24 h Rhythmicity of Spontaneous Locomotor Activity in the Triple Transgenic Mouse for Alzheimer’s Disease (3xTg-AD) in a Jet Lag Protocol: Correlations with Retinal Sensitivity., Journal of Circadian Rhythms, January 2021; 19(1), 1-15

9. Aroña, R.M., Arnold, E., Macías, F., López-Casillas, F., Clapp, C., Martínez de la Escalera, G. , Vasoinhibin generation and effect on neuronal apoptosis in the hippocampus of late mouse embryos. , AMERICAN JOURNAL OF PHYSIOLOGY: Regulatory, Integrative and Comparative Physiology, April 2020; 318(4), R760-771

10. Arnold, E., Thebault, S., Aroña, R.M., Martínez de la Escalera, G., Clapp, C. , Prolactin mitigates deficiencies of retinal function associated with aging. , Neurobiology of Aging, January 2020; 85, 38-48

11. Melo, Z., Castillo, X., Moreno-Carranza, B., Ledesma-Colunga, M.G., López-Casillas, F., Ruíz-Herrera, X., Clapp, C., Martínez de la Escalera, G. , Vasoinhibin suppresses nerve growth factor-induced differentiation and survival of PC12 pheochromocytoma cells. , Neuroendocrinology, August 2019; 109(2), 152-164

12. Castillo, X., Melo, Z., Varela-Echevarría, A., Tamáriz, E., Aroña, R.M., Arnold, E., Clapp, C., Martínez de la Escalera, G. , Vasoinhibins suppresses the ability of NGF and VEGF to stimulate neurite growth in rat primary sensory neurons. , Neuroendocrinology, March 2018; 106(3), 221-233

13. Ruiz-Herrera X, de Los Ríos EA, Díaz JM, Lerma-Alvarado RM, de la Escalera LM, López-Barrera F, Lemini M, Arnold E, de la Escalera GM, Clapp C, Macotela Y., Prolactin Promotes Adipose Tissue Fitness and Insulin Sensitivity in Obese Males., Endocrinology, January 2017; 158(1), 56-68

14. Kong D, Gong L, Arnold E, Shanmugam S, Fort PE, Gardner TW, Abcouwer SF., Insulin-like growth factor 1 rescues R28 retinal neurons from apoptotic death through ERK-mediated BimEL phosphorylation independent of Akt., Experimental Eye Research, October 2016; 151, 82-95

15. Meléndez García R*, Arredondo Zamarripa R*, Arnold E* (*, equal contribution), Ruiz-Herrera X, Noguez Imm R, Baeza Cruz G, Adán N, Binart N, Riesgo-Escovar N, Goffin V, Ordaz B, Peña-Ortega F, Martínez-Torres A, Clapp C, and Thebault S, Prolactin protects retinal pigment epithelium by inhibiting SIRT2-dependent cell death, EBioMedicine, April 2016; 7, 35-49

16. Díaz-Lezama N, Wu Z, Adán-Castro E, Arnold E, Vázquez-Membrillo M, Arredondo-Zamarripa D, Ledesma-Colunga MG, Moreno-Carranza B, Martinez de la Escalera G, Colosi P, Clapp C. , Diabetes enhances the efficacy of AAV2 vectors in the retina: therapeutic effect of AAV2 encoding vasoinhibin and soluble VEGF receptor 1, Laboratory Investigation, November 2015, 1-13

17. Arredondo, D., Díaz-Lezama, N., Meléndez, R., Chávez Balderas, J., Adán, N., Ledesma-Colunga, M.G., Arnold, E., Clapp, C., Thebault, S. , Vasoinhibins regulate the inner and outer blood-retinal barrier and limit retinal oxidative stress, Frontiers in Cellular Neuroscience, October 2014

18. Arnold, E., Thebault, S., Baeza-Cruz, G., Quintanar-Stephano, A., Condés-Lara, M., Rojas-Piloni, G., Binart, N., Martínez de la Escalera, G., Clapp, C., The hormone prolactin is a novel endogenous trophic factor able to regulate reactive glia and to limit retinal degeneration. , Journal Of Neuroscience, January 2014; 34(5), 1868-1878

19. Ramírez, M., Wu, Z., Moreno-Carranza, B., Jeziorski, M.C., Arnold, E., Díaz-Lezama, N., Martínez de la Escalera, G., Colosi, P., Clapp, C. , Vasoinhibin gene transfer by Adeno-Associated Virus type 2 protects against VEGF- and diabetes-induced retinal vasopermeability. , Investigative Ophthalmology & Visual Science, November 2011; 52(11), 8944-8950

20. Arnold E, Rivera JC, Thebault S, Moreno-Páramo D, Quiroz-Mercado H, Quintanar-Stéphano A, Binart N, Martínez de la Escalera G, Clapp C. , High levels of serum prolactin protect against diabetic retinopathy by increasing ocular vasoinhibins. , Diabetes, December 2010; 59(12), 3192-3197

21. Cruz-Soto ME, Cosío G, Jeziorski MC, Vargas-Barroso V, Aguilar MB, Cárabez A, Berger P, Saftig P, Arnold E, Thebault S, Martínez de la Escalera G, Clapp C, Cathepsin D is the primary protease for the generation of adenohypophyseal vasoinhibins: cleavage occurs within the prolactin secretory granules, Endocrinology, December 2009; 150(12), 5446-54

22. Melo, A.I., Pérez-Ledezma, M., Clapp, C., Rivera, J.C., Fleming, A.S., Arnold, E. , Effects of prolactin deficiency during the early postnatal period on the development of maternal behavior in female rats: Mother’s milk makes the difference. , Hormones And Behavior, January 2009; 59(1), 281-291

23. Clapp C, Thebault S, Arnold E, García C, Rivera JC, Martínez de la Escalera G., Vasoinhibins: Novel inhibitors of ocular angiogenesis, American Journal Of Physiology, Endocrinology And Metabolism, October 2008; 295(4), 772-778

24. García, C., Aranda, J., Arnold, E., Thebault, S., Macotela, J., López-Casillas, F., Mendoza, V., Quiroz-Mercado, H., Lin, S.H., Martínez de la Escalera, G., Clapp, C., Vasoinhibins prevent increased retinal vasopermeability associated with diabetic retinopathy via protein phosphatase 2A-dependent eNOS inactivation, Journal Of Clinical Investigation, June 2008; 118(6), 2291-2300

25. Moreno-Páramo, D., Rivera, J.C., Aranda, J., Salazar, N., Arnold, E., Quiróz-Mercado, H., Martínez de la Escalera, G., Clapp, C., RETINOPATIA DIABETICA Y VASOINHIBINAS., Revista de Investigacion Clinica, January 2007; 19(0), 290-297

Most Recent Advised Theses

1. Paulette Heredia Mejía (estudiante), Análisis del efecto de la prolactina en la respuesta inflamatoria de los astrocitos en condiciones de estrés oxidante., Modalidad: Tesis, Químico Farmacéutico Biotecnólogo, Licenciatura, Universidad del Valle de México Campus Querétaro, Universidad del Valle de México, Fecha de presentación de examen: 2024-11-11, Arnold Hernández Edith (Director)

2. Miriam Nayely Ulloa Zamudio (estudiante), El papel protector de la prolactina sobre el daño inducido por un estrés oxidativo en astrocitos de rata., Modalidad: Por proyecto de investigación, Maestría en Ciencias (Neurobiología), Maestría, Instituto de Neurobiología UNAM-Juriquilla, INB-UNAM, Instituto de Neurobiología UNAM-Juriquilla, Fecha de presentación de examen: 2018-11-23, Arnold Hernández Edith (Director)

3. Elva Hortencia Adán Castro, (estudiante), Análisis del efecto de la hiperprolactinemia inducida por sulpirida sobre la retinopatía diabética experimental., Modalidad: Por proyecto de investigación, Maestría en Ciencias (Neurobiolgía), UNAM. , Maestría, Instituto de Neurobiología UNAM-Juriquilla, INB-UNAM, Instituto de Neurobiología UNAM-Juriquilla, Fecha de presentación de examen: 2017-07-27, Clapp Jiménez L María del Carmen (Director), Arnold Hernández Edith (Director)

4. Fernando Macías Prado (estudiante), Regulación del sistema prolactina/vasoinhibinas en astrocitos hipocampales a lo largo del desarrollo., Modalidad: Tesis, Biología, Licenciatura, Escuela de Biología, Benemérita Universidad Autónoma de Puebla, Fecha de presentación de examen: 2017-06-12, Arnold Hernández Edith (Director)

5. Karla Gabriela Ortiz Gómez (estudiante), Análisis del efecto de la prolactina (PRL) sobre la supervivencia de los astrocitos corticales sometidos a un estrés oxidativo, Modalidad: Tesis, Químico Farmacéutico Biólogo , Licenciatura, Facultad de Química, Universidad Autonoma de Queretaro, Fecha de presentación de examen: 2016-08-11, Arnold Hernández Edith (Director)