Plataforma de Información Curricular

Lineas de investigación

Regulación hormonal de los vasos sanguíneos, la inflamación, el crecimiento, el metabolismo y la supervivencia celular

Publicaciones recientes

1. Robles JP, Zamora M, Siqueiros-Marquez L, Adan-Castro E, Ramirez-Hernadez G, Nuñez FF, Lopez-Casillas F, Millar RP, Bertsch T, Martínez de la Escalera G, Tiebel J, Clapp C. , The HGR motif is the antiangiogenic determinant of vasoinhibin: implications for a therapeutic orally active oligopeptide. , Angiogenesis, marzo de 2022; 25, 57-70

2. Friedrich C, Neugebauer L, Zamora M, Robles JP, Martínez de la Escalera G, Clapp C, Bertsch T, Triebel J. , Plasmin generates vasoinhibin-like peptides by cleaving prolactin and placental lactogen. , Molecular And Cellular Endocrinology, noviembre de 2021; 538(111471)

3. Robles JP, Zamora M, Martínez de la Escalera G, Clapp C. , The spike protein of SARS-CoV-2 induces endothelial inflammation through integrin α5β1 and NF-κB. , BioRxiv, noviembre de 2021

4. Zamora M, Robles JP, Aguilar MB, Romero-Gómez SJ, Bertsch T, Martínez de la Escalera G, Tiebel J, Clapp C. , Thrombin cleaves prolactin into a potent 5.6 kDa vasoinhibin: Implication for tissue repair. , Endocrinology, agosto de 2021; 162, 1-15

5. Ramírez-Hernández G., Adán-Castro E., Díaz-Lezama N., Ruiz-Herrera X, Martínez de la Escalera G., Macotela Y, Clapp C. , Global deletion of the prolactin receptor aggravates streptozotocin-induced diabetes in mice. , Frontieres in Endocrinology (Lausanne), mayo de 2021; 12, 619696

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Publicaciones

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1. Robles JP, Zamora M, Siqueiros-Marquez L, Adan-Castro E, Ramirez-Hernadez G, Nuñez FF, Lopez-Casillas F, Millar RP, Bertsch T, Martínez de la Escalera G, Tiebel J, Clapp C. , The HGR motif is the antiangiogenic determinant of vasoinhibin: implications for a therapeutic orally active oligopeptide. , Angiogenesis, marzo de 2022; 25, 57-70

2. Friedrich C, Neugebauer L, Zamora M, Robles JP, Martínez de la Escalera G, Clapp C, Bertsch T, Triebel J. , Plasmin generates vasoinhibin-like peptides by cleaving prolactin and placental lactogen. , Molecular And Cellular Endocrinology, noviembre de 2021; 538(111471)

3. Robles JP, Zamora M, Martínez de la Escalera G, Clapp C. , The spike protein of SARS-CoV-2 induces endothelial inflammation through integrin α5β1 and NF-κB. , BioRxiv, noviembre de 2021

4. Zamora M, Robles JP, Aguilar MB, Romero-Gómez SJ, Bertsch T, Martínez de la Escalera G, Tiebel J, Clapp C. , Thrombin cleaves prolactin into a potent 5.6 kDa vasoinhibin: Implication for tissue repair. , Endocrinology, agosto de 2021; 162, 1-15

5. Ramírez-Hernández G., Adán-Castro E., Díaz-Lezama N., Ruiz-Herrera X, Martínez de la Escalera G., Macotela Y, Clapp C. , Global deletion of the prolactin receptor aggravates streptozotocin-induced diabetes in mice. , Frontieres in Endocrinology (Lausanne), mayo de 2021; 12, 619696

6. Müller N, Robles JP, Zamora M, Ebnet J, Markl-Hahn H, Martínez de la Escalera G, Clapp C, Bertsch, Tiebel J. , Development of vasoinhibin-specific monoclonal antibodies, Frontieres in Endocrinology (Lausanne), marzo de 2021; 12, 645085

7. García-González MA, Miguel-Martínez AD, González-Hernández A, Zamora M, Adán-Castro E, Triebel J, Bertsch T, López-López JG, Martínez de la Escalera G, Robles JP, Clapp C, Villalón CM. , Cardiovascular safety of VIAN-c4551, an antiangiogenic peptide derived from vasoinhibin. , Drug Development Research, noviembre de 2025; 86, e70177

8. García-González MA, Miguel-Martínez AD, González-Hernández A, Zamora M, Adán-Castro E, Triebel J, Bertsch T, López-López JG, Martínez de la Escalera G, Robles JP, Clapp C, Villalón CM. , Cardiovascular safety of VIAN-c4551, an antiangiogenic peptide derived from vasoinhibin. , Drug Development Research, noviembre de 2025; 86, e70177

9. Zamora M, Clapp C, Martínez de la Escalera G., Robles JP, Integrin alpha5beta1 mediates the inhibitory effects of vasoinhibin on angiogénesis and vascular permeability, Journal Of Biological Chemistry, noviembre de 2025; 0, 110978

10. Ocampo-Ruíz AL, Dena-Beltrán JL, Dimas-Rufino MA, Castillo X, Vázquez-Carrillo DI, Silos-Guajardo A, Ruíz-Herrera X, Garay E, Martínez de la Escalera G, Clapp C, Arellano RO, Cisneros-Mejorado AJ, Macotela Y. , Prolactin receptor deficiency promotes hypomyelination in white matter tracts during postnatal central nervous system maturation in mice, Glia, octubre de 2025; 1, 14

11. Ocampo-Ruíz AL, Dena-Beltrán JL, Dimas-Rufino MA, Castillo X, Vázquez-Carrillo DI, Silos-Guajardo A, Ruíz-Herrera X, Garay E, Martínez de la Escalera G, Clapp C, Arellano RO, Cisneros-Mejorado AJ, Macotela Y. , Prolactin receptor deficiency promotes hypomyelination in white matter tracts during postnatal central nervous system maturation in mice, Glia, octubre de 2025; 1, 14

12. Adán-Castro E, Zamora M, Granados-Carrasco D, Siqueiros-Marquez L, García-Rodrigo JF, Bertsch T, Triebel J, Martínez de la Escalera G, Robles JP, Clapp C, Topical eye administration of the antiangiogenic peptide VIAN-c4551 protects against experimental diabetic macular edema, Scientific Reports, julio de 2025; 15, 26767

13. Adán-Castro E, Zamora M, Granados-Carrasco D, Siqueiros-Marquez L, García-Rodrigo JF, Bertsch T, Triebel J, Martínez de la Escalera G, Robles JP, Clapp C, Topical eye administration of the antiangiogenic peptide VIAN-c4551 protects against experimental diabetic macular edema, Scientific Reports, julio de 2025; 15, 26767

14. Zamora M, Clapp C, Martínez de la Escalera G, Robles JP. , Integrin α5β1 mediates the inhibitory effects of vasoinhibin on angiogenesis and 1 vascular permeability., BioRxiv, julio de 2025

15. Zamora M, Clapp C, Martínez de la Escalera G, Robles JP. , Integrin α5β1 mediates the inhibitory effects of vasoinhibin on angiogenesis and 1 vascular permeability., BioRxiv, julio de 2025

16. Dena-Beltrán JL, Ocampo-Ruíz AL, Vázquez-Carrillo DI, de los Ríos EA, Ruíz-Herrera X, Valle-Pacheco M, Robles-Torres SI, Martínez de la Escalera G, Clapp C, Macotela Y, Prolactin maintains the neonatal phenotype of enterocytes during lactation in newborn mice, AJP Cell physiology, mayo de 2025; 329, C17-C30

17. Dena-Beltrán JL, Ocampo-Ruíz AL, Vázquez-Carrillo DI, de los Ríos EA, Ruíz-Herrera X, Valle-Pacheco M, Robles-Torres SI, Martínez de la Escalera G, Clapp C, Macotela Y, Prolactin maintains the neonatal phenotype of enterocytes during lactation in newborn mice, AJP Cell physiology, mayo de 2025; 329, C17-C30

18. Pérez AL, Zamora M, Bahena M, Arámburo-Williams R, Adán-Castro E, Bertsch T, Triebel J, Martínez de la Escalera G, Robles JP, Clapp C, The antiangiogenic peptide VIAN-c4551 inhibits lung melanoma metastasis in mice by reducing pulmonary vascular permeability, Plos One, mayo de 2025; 20(5), e0316983

19. Pérez AL, Zamora M, Bahena M, Arámburo-Williams R, Adán-Castro E, Bertsch T, Triebel J, Martínez de la Escalera G, Robles JP, Clapp C, The antiangiogenic peptide VIAN-c4551 inhibits lung melanoma metastasis in mice by reducing pulmonary vascular permeability, Plos One, mayo de 2025; 20(5), e0316983

20. Nuñez FF, Siqueiros-Marquez L, Adán-Castro E, Zamora M, Robles JP, Ruíz-Herrera X, Bertsch T, Triebel J, Martínez de la Escalera G, Clapp C, Vasoinhibin is generated by the renin-angiotensin system, Endocrinology, febrero de 2025; 166(3), bqaf023

21. Nuñez FF, Siqueiros-Marquez L, Adán-Castro E, Zamora M, Robles JP, Ruíz-Herrera X, Bertsch T, Triebel J, Martínez de la Escalera G, Clapp C, Vasoinhibin is generated by the renin-angiotensin system, Endocrinology, febrero de 2025; 166(3), bqaf023

22. Adán-Castro E, Zamora M, Granados-Carrasco D, Siqueiros-Márquez L, Garía-Rodrigo JF, Bertsch T, Triebel J, Martínez de la Escalera G, Robles JP, Clapp C. , Topical ophthalmic administration of VIAN-c4551 antiangiogenic peptide for diabetic macular edema: Preclinical efficacy and ocular pharmacoxinetics. , BioRxiv, noviembre de 2024

23. Macías F, Ulloa M, Clapp C, Martínez de la Escalera G, Arnold E. , Prolactin protects hippocampal neurons against H2O2-induced neurotoxicity by suppressing BAX and NOX4 via the NF-κB signaling pathway. , Plos One, noviembre de 2024; 19(11), e0313328

24. Macías F, Ulloa M, Clapp C, Martínez de la Escalera G, Arnold E. , Prolactin protects hippocampal neurons against H2O2-induced neurotoxicity by suppressing BAX and NOX4 via the NF-κB signaling pathway. , Plos One, noviembre de 2024; 19(11), e0313328

25. Robles JP, Zamora M, Garcia-Rodrigo JF, Perez AL, Bertsch T, Martínez de la Escalera G, Triebel J, Clapp C. , The apoptotic, inflammatory, and fibrinolytic actions of vasoinhibin are in a motif different from its antiangiogenic HGR motif. , Endocrinology, noviembre de 2024; 165, 1-12

26. Zamora M, Harris D, Davies N, Ebnet J, Radermacher P, Brucker C, Waller C, Robles JP, Bertsch T, Clapp C, Triebel J., Immunometric and functional measurement of endogenous vasoinhibin in human sera., Frontiers in Endocrinology, noviembre de 2024; 15, 1345996

27. Castillo X, Ortíz G, Arnold E, Wu Z, Tovar y Romo LB, Clapp C, Martínez de la Escalera G. , The influence of the prolactin/vasoinhibin axis on post-stroke lesion volume, astrogliosis, and survival. Journal of , Journal Of Neuroendocrinology, julio de 2024; 2024, e13415

28. Castillo X, Ortíz G, Arnold E, Wu Z, Tovar y Romo LB, Clapp C, Martínez de la Escalera G. , The influence of the prolactin/vasoinhibin axis on post-stroke lesion volume, astrogliosis, and survival. Journal of , Journal Of Neuroendocrinology, julio de 2024; 2024, e13415

29. Ulloa M, Macías F, Clapp C, Martínez de la Escalera G, Arnold E. , Prolactin is an endogenous antioxidant factor in astrocytes that limits oxidative stress-induced astrocytic cell death via the STAT3/NRF2 signaling pathway., Neurochemical Research, mayo de 2024; 49, 1879-1901

30. Ulloa M, Macías F, Clapp C, Martínez de la Escalera G, Arnold E. , Prolactin is an endogenous antioxidant factor in astrocytes that limits oxidative stress-induced astrocytic cell death via the STAT3/NRF2 signaling pathway., Neurochemical Research, mayo de 2024; 49, 1879-1901

31. Vázquez-Carrillo DI, Ocampo-Ruíz AL, Báez-Mesa A, Ramírez-Hernández G, Adán-Castro E, García-Rodrigo JF, Dena-Beltrán JL, de los Ríos EA, Sánchez-Martínez MK, Ortíz-Arballo MG, Martínez de la Escalera G, Clapp C, Macotela Y. , Dopamine D2 receptor antagonist counteracts hyperglycemia and insulin resistance in diet-induced obese male mice, Plos One, abril de 2024; 19, e0301496

32. Vázquez-Carrillo DI, Ocampo-Ruíz AL, Báez-Mesa A, Ramírez-Hernández G, Adán-Castro E, García-Rodrigo JF, Dena-Beltrán JL, de los Ríos EA, Sánchez-Martínez MK, Ortíz-Arballo MG, Martínez de la Escalera G, Clapp C, Macotela Y. , Dopamine D2 receptor antagonist counteracts hyperglycemia and insulin resistance in diet-induced obese male mice, Plos One, abril de 2024; 19, e0301496

33. Núñez-Amaro CD, López M, Adán-Castro E, Robles-Osorio ML, García-Franco L, García-Roa M, Villalpando-Robles Y, Ramírez-Neria P, Pineiro N, Rubio-Mijangos JF, Sánchez J, Ramírez-Hernández G, Siqueiros-Márquez L, Díaz-Lezama N, López-Star E, Bertsch T, Martínez de la Escalera G, Triebel J, Clapp C. , Levosulpiride for the treatment of diabetic macular oedema: A phase 2 randomized clinical trial. , EYE, febrero de 2024; 38, 520-528

34. Núñez-Amaro CD, López M, Adán-Castro E, Robles-Osorio ML, García-Franco L, García-Roa M, Villalpando-Robles Y, Ramírez-Neria P, Pineiro N, Rubio-Mijangos JF, Sánchez J, Ramírez-Hernández G, Siqueiros-Márquez L, Díaz-Lezama N, López-Star E, Bertsch T, Martínez de la Escalera G, Triebel J, Clapp C. , Levosulpiride for the treatment of diabetic macular oedema: A phase 2 randomized clinical trial. , EYE, febrero de 2024; 38, 520-528

35. Luzardo-Ocampo I, Ocampo-Ruíz AL, Dena-Beltrán JL, Martínez de la Escalera G, Clapp C, Macotela Y. , The diversity of gut microbiota at weaning is altered in prolactin receptor null mice. , Nutrients, noviembre de 2023; 15, 3447

36. Luzardo-Ocampo I, Ocampo-Ruíz AL, Dena-Beltrán JL, Martínez de la Escalera G, Clapp C, Macotela Y. , The diversity of gut microbiota at weaning is altered in prolactin receptor null mice. , Nutrients, noviembre de 2023; 15, 3447

37. García-Rodrigo JF, Ortíz-Arballo G, Martínez-Díaz OF, Furuzawa-Carballeda J, Ruíz-Herrera X, Macías F, Ledesma-Colunga MG, Martínez de la Escalera G, Clapp C. , Prolactin inhibits or stimulates the inflammatory response of joint tissues in a cytokine-dependent manner. , Endocrinology, octubre de 2023; bqad156, 1-14 online

38. García-Rodrigo JF, Ortíz-Arballo G, Martínez-Díaz OF, Furuzawa-Carballeda J, Ruíz-Herrera X, Macías F, Ledesma-Colunga MG, Martínez de la Escalera G, Clapp C. , Prolactin inhibits or stimulates the inflammatory response of joint tissues in a cytokine-dependent manner. , Endocrinology, octubre de 2023; bqad156, 1-14 online

39. Luzardo-Ocampo, I., Dena-Beltrán, J. L., Ruíz-Herrera, X., Ocampo-Ruiz, A. L., Martinez de la Escalera, G., Clapp, C., & Macotela, Y. , Obesity-derived alterations in the lactating mammary gland: focus on prolactin, Molecular And Cellular Endocrinology, octubre de 2023; 559, 111810 online

40. Luzardo-Ocampo, I., Dena-Beltrán, J. L., Ruíz-Herrera, X., Ocampo-Ruiz, A. L., Martinez de la Escalera, G., Clapp, C., & Macotela, Y. , Obesity-derived alterations in the lactating mammary gland: focus on prolactin, Molecular And Cellular Endocrinology, octubre de 2023; 559, 111810 online

41. Robles JP, Zamora M, Garcia-Rodrigo JF, Perez AL, Bertsch T, Martínez de la Escalera G, Triebel J, Clapp C. , The apoptotic, inflammatory, and fibrinolytic actions of vasoinhibin are in a motif different from its antiangiogenic HGR motif. , BioRxiv, octubre de 2023 online

42. Robles JP, Zamora M, Garcia-Rodrigo JF, Perez AL, Bertsch T, Martínez de la Escalera G, Triebel J, Clapp C. , The apoptotic, inflammatory, and fibrinolytic actions of vasoinhibin are in a motif different from its antiangiogenic HGR motif. , BioRxiv, octubre de 2023 online

43. Núñez-Amaro CD, López M, Adán-Castro E, Robles-Osorio ML, García-Franco L, García-Roa M, Villalpando-Robles Y, Ramírez-Neria P, Pineiro N, Rubio-Mijangos JF, Sánchez J, Ramírez-Hernández G, Siqueiros-Márquez L, Díaz-Lezama N, López-Star E, Bertsch T, Martínez de la Escalera G, Triebel J, Clapp C. , Levosulpiride for the treatment of diabetic macular oedema: A phase 2 randomized clinical trial. , EYE, marzo de 2023, 1-9

44. Núñez-Amaro CD, López M, Adán-Castro E, Robles-Osorio ML, García-Franco L, García-Roa M, Villalpando-Robles Y, Ramírez-Neria P, Pineiro N, Rubio-Mijangos JF, Sánchez J, Ramírez-Hernández G, Siqueiros-Márquez L, Díaz-Lezama N, López-Star E, Bertsch T, Martínez de la Escalera G, Triebel J, Clapp C. , Levosulpiride for the treatment of diabetic macular oedema: A phase 2 randomized clinical trial. , EYE, marzo de 2023, 1-9

45. Ruiz-Herrera X, Luzardo-Ocampo I, Martínez de la Escalera G, Clapp C, Macotela Y. , Differentiated mouse adipocytes in primary culture: A model of insulin resistance. , JOVE, febrero de 2023; 192, e63979

46. Clapp C, Ortíz G, García-Rodrigo JF, Ledesma-Colunga MG, Martínez-Díaz F, Adán N, Martínez de la Escalera G., Dual roles of prolactin and vasoinhibin in inflammatory arthritis, Frontiers in Endocrinology, diciembre de 2022; 13, 905756

47. Luzardo-Ocampo I, Dena-Beltrán JL, Martínez de la Escalera G, Clapp C, Macotela Y. , Obesity-derived alterations in the lactating mammary gland: focus on prolactin. , Molecular And Cellular Endocrinology, noviembre de 2022; 559, 111810

48. Macotela Y, Ruíz-Herrera X, Vázquez D, Ramírez-Hernández G, Martínez de la Escalera G, Clapp C. , The beneficial metabolic effects of prolactin. , Frontiers in Endocrinology, octubre de 2022; 13, 103389

49. Triebel J, Bertsch T, Clapp C. , Prolactin and vasoinhibin are endogenous players in diabetic retinopathy revisited. , Frontiers in Endocrinology, octubre de 2022; 13, 994898

50. Triebel J, Robles JP, Zamora Z, Clapp C, Bertsch. , New horizons in specific hormone proteolysis. , Trends In Endocrinology And Metabolism, octubre de 2022; 33, 371-377

51. Adán-Castro E, Siqueiros-Márquez L, Ramírez-Hernández G, Díaz-Lezama N, Ruiz-Herrera X, Nuñez FF, Nuñez-Amaro CD, Robles-Osorio ML, Bertsch T, Triebel J, Martínez de la Escalera G, Clapp C. , Sulpiride-induced hyperprolactinemia increases retinal vasoinhibin and protects against diabetic retinopathy in rats. , Journal of Neuroendocrinology: Translational and Clinical Neuroendocrinology, agosto de 2022; 34, e13091

52. Martínez de la Escalera G, Macotela Y, Clapp C. , A new experimental tool towards understanding the regulation of human prolactin secretion and functions. , Endocrinology, agosto de 2022; 163(4), 1-2

53. Ortíz G, Ledesma-Colunga MG, Zhijian Wu Z, García-Rodrigo JF, Adán N, Martínez-Díaz F, de Los Ríos EA, López-Barrera F, Martínez de la Escalera G, Clapp C. , Vasoinhibin is generated and promotes inflammation in mild antigen-induced arthritis. , Endocrinology, agosto de 2022; 163(5), 1-12

54. Hernández-Soto R, Adán-Castro E, Clapp C, Peña-Ortega F. , Main olfactory bulb reconfiguration by prolonged passive ofactory experience correlates with increased brain-derived neurotrophic factor and improved innate olfaction. , European Journal Of Neuroscience, mayo de 2022; 55, 1141-1161

55. Leuchs A, Davies N, Friedrich C, Trier S, Clapp C, Bertsch T, Triebel J. , A comparative phylogenetic analysis of prolactin cleavage sites for the generation of vasoinhibin in vertebrates. , General and Comparative Endocrinology, abril de 2022; 320, 114011

56. Robles JP, Zamora M, Martínez de la Escalera G, Clapp C. , The spike protein of SARS-CoV-2 induces endothelial inflammation through integrin α5β1 and NF-κB signaling, Journal Of Biological Chemistry, marzo de 2022; 298(3), 101695

57. Ruggiero C, Altieri B, Arnold E, Siqueiros-Marquez L, Doghman-Bouguerra M, Detomas M, Durand N, Jarjat M, Chatonnet F, Fassnacht M, Deutschbein T, Clapp C, Lalli E. , Analysis of mouse adrenal gland links prolactin signaling and adrenal-specific super-enhancers to human endocrine disorders. , Clinical and Translational Medicine, noviembre de 2021; 11, e630

58. Markl-Hahn H, Neugebauer L, Lenke L, Ecker S, Merz T, McCook O, Khouder n, Bruckeer C, Radermacher P, Waller C, Clapp C, Bertsch T, Triebel J. , Human placental tissue contains a placental lactogen derived vasoinhibin. , Journal of the Endocrine Society, octubre de 2021; 6, 1-14

59. Macotela Y, Triebel J, Clapp C. , Opinion: Time for a new perspective on prolactin in metabolism. , Trends In Endocrinology And Metabolism, noviembre de 2020; 31, 276-286

60. Núñez-Amaro, D., Moreno-Vega, A.I., Adán-Castro, E., Zamora, M., García-Franco, R., Ramírez-Neria, P., García-Roa, M., Villalpando, Y., Robles, J.P., Ramírez-Hernández, G., López, M., Sánchez, J., López-Star, E., Bertsch, T, Martínez de la Escalera, G., Robles-Osorio, M.L., Triebel, J., Clapp, C. , Levosulpiride increases the levels of prolactin and antiangiogenic vasoinhibin in the vitreous of patients with proliferative diabetic retinopathy. , Translational Vision Science and Technology, noviembre de 2020; 9(9), 27

61. Ortiz, G., Ledesma-Colunga, M.G., Wu, Z., García-Rodrigo, J.F., Adán, N., Martínez de la Escalera, G., Clapp, C. , Vasoinhibin reduces joint inflammation, bone loss, and the angiogenesis and vasopermeability of the pannus in murine antigen-induced arthritis. , Laboratory Investigation, noviembre de 2020; 100, 1068-1079

62. Aroña, R.M., Arnold, E., Macías, F., López-Casillas, F., Clapp, C., Martínez de la Escalera, G. , Vasoinhibin generation and effect on neuronal apoptosis in the hippocampus of late mouse embryos. , AMERICAN JOURNAL OF PHYSIOLOGY: Regulatory, Integrative and Comparative Physiology, abril de 2020; 318(4), R760-771

63. Vázquez-Membrillo, M., Siqueiros-Márquez, L., Núñez, F.F., Díaz-Lezama, N., Adán-Castro, E., Ramírez-Hernández, G., Adán, N., Macotela, Y., Martínez de la Escalera, G., Clapp, C. , Prolactin stimulates the vascularization of the retina in newborn mice exposed to hyperoxia, Journal Of Neuroendocrinology, abril de 2020; e12858

64. Triebel, J., Schauer, N., Zamora, M., Moreno-Vega, A.I., Martínez de la Escalera, G., Clapp, C., Bertsch, T. , Matrix metalloproteases and cathepsin D in human serum do not cleave prolactin to generate vasoinhibin. , Clinical Laboratory, marzo de 2020; 66, 877-866

65. Ponce, A.J., Galván-Salas, T., Lerma-Alvarado, R.M., Ruíz-Herrera, X., Cárdenas, L.E., Hernández, T., Valencia, R., Martínez de la Escalera, G., Clapp, C., Macotela, Y. , Low prolactin levels associate with insulin resistance and visceral adipocyte hypertrophy in humans. , Endocrine, febrero de 2020; 67, 331-343

66. Arnold, E., Thebault, S., Aroña, R.M., Martínez de la Escalera, G., Clapp, C. , Prolactin mitigates deficiencies of retinal function associated with aging. , Neurobiology of Aging, enero de 2020; 85, 38-48

67. Lenke, L., Martínez de la Escalera, G., Clapp, C., Bertsch, T., Triebel, J. , A dysregulation of the prolactin/vasoinhibin axis appears to contribute to preeclampsia. , Frontiers in Endocrinology, enero de 2020; 10, 893

68. Pérez-Ortíz AC, Peralta-Ildefonso MJ, Lira-Romero E, Moya-Albor E, Brieva J, Ramírez-Zanchez I, Clapp C, Luna-Angulo A, Rendón A, Adán-Castro E, Ramírez-Hernández G, Díaz-Lexama N, Coral-Vázquez RM, Estrada-Mena FJ. , Lack of delta-sarcoglycan (Sgcd) results in retinal degeneration resembling geographic atrophy AMD. , International Journal of Molecular Sciences, noviembre de 2019; 20, 5480

69. Clapp, C., Díaz-Lezama, N., Adan-Castro, E., Ramírez-Hernandez, G., Moreno-Carranza, B., Sarti, A.C., Falzoni, S., Solini, A., Di Virgilio, F. , Pharmacological blockade of the P2X7 receptor reverses retinal damage in a rat model of type 1 diabetes. , acta diabetologica, octubre de 2019; 56, 1031-1036

70. Melo, Z., Castillo, X., Moreno-Carranza, B., Ledesma-Colunga, M.G., López-Casillas, F., Ruíz-Herrera, X., Clapp, C., Martínez de la Escalera, G. , Vasoinhibin suppresses nerve growth factor-induced differentiation and survival of PC12 pheochromocytoma cells. , Neuroendocrinology, agosto de 2019; 109(2), 152-164

71. Moreno-Carranza, B., Robles, J.P., Cruces-Solís, H., Ferrer-Ríos, M.G., Aguilar-Rivera, E., Yupanki, M., Martínez de la Escalera, G., Clapp, C. , Sequence optimization and glycosylation of vasoinhibin: Pitfalls of recombinant production. , Protein Expression And Purification, abril de 2019; 161, 49-56

72. Triebel, J., Robles, J.P., Zamora, M., Martínez de la Escalera, G., Bertsch, T, Clapp, C. , Regulator of angiogenesis and vascular function: A 2019 update of the vasoinhibin nomenclature. , Frontiers in Endocrinology, febrero de 2019; 10, 214

73. Robles, J.P., Zamora, M., Velasco-Bolom, J.L., Tovar, M., Garduño-Juárez, R., Bertsch, T., Martínez de la Escalera, G., Triebel, J., Clapp, C. , Vasoinhibins comprise a three-helix bundle and their antiangiogenic domain is located within the first 79 residues. , Scientific Reports, noviembre de 2018; 8(17111), 1-17

74. De los Ríos EA, Ruiz-Herrera X, Tinoco-Pantoja V, López-Barrera F, Martínez de la Escalera G, Clapp C, Macotela Y. , Impaired prolactin actions mediate altered offspring metabolism induced by maternal high fat feeding during lactation. , The FASEB Journal, junio de 2018; 32(6), 3457-3470

75. Moreno-Carranza B, Bravo-Manríquez M, Baez A, Ledesma-Colunga MG, Ruiz-Herrera X, Reyes-Ortega P, de los Ríos EA, Macotela Y, Martínez de la Escalera G, Clapp C., Prolactin regulates liver growth during postnatal development in mice. , American Journal Of Physiology-Cell Physiology, junio de 2018; 314(6), R902-R908

76. Robles-Osorio, L., García-Franco, R., Núñez-Amaro, D., Mira-Lorenzo, X., Ramírez-Neria, P., Hernández, W., López-Star, E., Bertsch, T., Martínez de la Escalera, G., Triebel, J., Clapp, C. , Basis and design of a randomized clinical trial to evaluate the effect of levosulpiride on retinal alterations in patients with diabetic retinopathy and diabetic macular edema. , Frontiers in Endocrinology, mayo de 2018; 9(242), 1-8

77. Castillo, X., Melo, Z., Varela-Echevarría, A., Tamáriz, E., Aroña, R.M., Arnold, E., Clapp, C., Martínez de la Escalera, G. , Vasoinhibins suppresses the ability of NGF and VEGF to stimulate neurite growth in rat primary sensory neurons. , Neuroendocrinology, marzo de 2018; 106(3), 221-233

78. Triebel, J., Martínez de la Escalera, G., Clapp, C., Bertsch, T. , From bench to bedside: translating the prolactin/vasoinhibin axis. , Frontiers in Endocrinology, diciembre de 2017; 8, 342

79. Triebel, J., Friedrich, C.J., Leuchs, A., Martínez de la Escalera, G., Clapp, C., Bertsch, T. , Human prolactin point mutations and their projected effect on vasoinhibin generation and vasoinhibin-related diseases., Frontiers in Endocrinology, noviembre de 2017; 8, 294

80. Arredondo-Zamarripa, D., Noguez-Imm, R., Chávez-Balderas, J., Fiorio Pla, A., Gkika, D., Prevarskaya, N., Martínez-Torres, A., Clapp, C., Thebault, S. , TRPV4 channel blockage contributes to the inhibition of blood-retinal barrier breakdown by vasoinhibins during diabetes. , Scientific Reports, octubre de 2017

81. Triebel, J., Martínez de la Escalera, G., Clapp, C., Bertsch, T. , Vasoinhibins may contribute to postpartum depression. , Frontiers in Psychiatry, octubre de 2017; 8, 167

82. Ledesma-Colunga, M.G., Adan N., Ortiz, G., Solis-Gutierrez, M., López-Barrera, F., Martínez de la Escalera, G., Clapp, C. , Prolactin blocks the expression of receptor activator of nuclear factor kB ligand and reduces osteoclastogenesis and bone loss in murine inflammatory arthritis. , Arthritis Research & Therapy, agosto de 2017; 19, 93-109

83. Triebel, J., Clapp, C., Martínez de la Escalera, G., Bertsch, T. , Vasoinhibin serum levels are required to demonstrate their role in peripartum cardiomyopathy etiopathology, Journal of the American Society for Artificial Internal Organs, agosto de 2017; 63, e50

84. Triebel, J., Clapp, C., Martínez de la Escalera, G., Bertsch, T. , Commentary: Prolactin Alters Blood Pressure by Modulating the Activity of Endothelial Nitric Oxide Synthase, Frontiers in Endocrinology, mayo de 2017; 8, 105

85. Triebel, J., Clapp, C., Martínez de la Escalera, G., Bertsch, T. , Remarks on the prolactin hypothesis of peripartum cardiomyopathy, Frontiers in Endocrinology, abril de 2017; 8, 77

86. Zepeda-Romero, L.C., Vázquez-Membrillo, M., Adán-Castro, E., Gómez-Aguayo, F., Gutiérrez-Padilla, J.A., Angulo-Castellanos, E., Barrera de León, J.C., González-Bernal, C., Quezada-Chalita, A., Meza-Anguiano, A., Díaz-Lesama, N., Martínez de la Escalera, G., Triebel, J., Clapp, C. , Higher prolactin and vasoinhibin serum levels associated with incidence and progression of retinopathy of prematurity. , Pediatric Research, marzo de 2017; 81(3), 473-479

87. Ruíz-Herrera, X., De los Ríos, E.A., Díaz, J.M., López-Barrera, F., Lemini, M., Arnold, E., Martínez de la Escalera, L., Lerma, R., Martínez de la Escalera, G., Clapp, C., Macotela, Y. , Prolactin promotes adipose tissue fitness and insulin sensitivity in obese males., Endocrinology, enero de 2017; 158(1), 56-68

88. Meléndez García R, Arredondo Zamarripa D, Arnold E, Ruiz-Herrera X, Noguez Imm R, Baeza Cruz G, Adán N, Binart N, Riesgo-Escovar J, Goffin V, Ordaz B, Peña-Ortega F, Martínez-Torres A, Clapp C, Thebault S. , Prolactin protects retinal pigment epithelium by inhibiting sirtuin 2-dependent cell death, EBioMedicine, noviembre de 2016; 7, 35-49

89. Clapp, C., Adán, N., Ledesma-Colunga, M.G., Solís-Gutiérrez, M., Triebel, J., Martínez de la Escalera, G. , The role of the prolactin/vasoinhibin axis in rheumatoid arthritis: An integrative overview. , Cellular and Molecular Life Sciences , julio de 2016; 73, 2929-2948

90. Triebel, J., Clapp, C., Bertsch, T. , Re: Peripartum cardiomyopathy treatment with dopamine agonist and subsequent pregnancy with a satisfactory outcome., Rev Bras Ginecol Obstet, mayo de 2016; 38, 580-582

91. Díaz-Lezama, N., Wu, Z., Adán-Castro, E., Vázquez-Membrillo, M., Arredondo-Zamarripa, D., Ledesma-Colunga, M.G., Moreno-Carranza, B., Martínez de la Escalera, G., Colosi, P. and Clapp, C. , Diabetes enhances the efficacy of AAV2 vectors in the retina: therapeutic effect of AAV2 encoding vasoinhibins and soluble VEGF receptor 1., Laboratory Investigation, marzo de 2016; 96, 283-295

92. Triebel, J., Bertsch, T., Bolheimer, C., Ríos-Barrera, D., Pearce C.F., Hüfner, M., Martínez de la Escalera, G., Clapp, C. , Principles of the prolactin/vasoinhibin axis. , AMERICAN JOURNAL OF PHYSIOLOGY: Regulatory, Integrative and Comparative Physiology, noviembre de 2015; 309, R1193-R1203

93. Triebel, J., Moreno-Vega, A.I., Vázquez-Membrillo, M., Nava, G., García-Franco, R., López-Star, E., Baldivieso-Hurtado, O., Ochoa, D., Macotela, Y., Bertsch, T., Martínez de la Escalera, G., Clapp, C. , High prolactin excretion in patients with diabetes mellitus and impaired renal function., Clinical Laboratory, noviembre de 2015; 61, 709-716

94. Lemini, M., Ruiz-Herrera, X., Ledesma-Colunga, M.G., Díaz-Lezama, N., De los Ríos, E., López-Barrera, F., Mendez, I., Martínez de la Escalera, G., Macotela, Y., Clapp, C. , Prolactin anterior pituitary expression and circulating levels are reduced in obese and diabetic rats: Role of TGFβ and TNFα., AMERICAN JOURNAL OF PHYSIOLOGY: Regulatory, Integrative and Comparative Physiology, octubre de 2015; 308, R792-R799

95. Triebel, J., Bertsch, T., Martínez de la Escalera, G., Clapp, C. Frontiers in Endocrinology, On the path towards classifying hormones of the vasoinhibin-family. , Frontiers in Endocrinology, febrero de 2015; 6, 1-2

96. Clapp, C., Thebault, S., Macotela, Y., Moreno-Carranza, B., Triebel, J., Martínez de la Escalera, G. , Regulation of blood vessels by prolactin and vasoinhibins. , Advances In Experimental Medicine And Biology, enero de 2015; 846, 83-95

97. Arredondo, D., Díaz-Lezama, N., Meléndez, R., Chávez Balderas, J., Adán, N., Ledesma-Colunga, M.G., Arnold, E., Clapp, C., Thebault, S. , Vasoinhibins regulate the inner and outer blood-retinal barrier and limit retinal oxidative stress, Frontiers in Cellular Neuroscience, octubre de 2014

98. Adán, N., Ledesma-Colunga, M.G., Reyes-López, A.L., Martínez de la Escalera, G., Clapp, C. , Arthritis and prolactin: A phylogenetic viewpoint. , General And Comparative Endocrinology, septiembre de 2014; 203, 132-136

99. Zamorano, M., Ledesma-Colunga, M.G., Adán, N., Vera-Massieu, C., Lemini, M., Méndez, I., Moreno-Carranza, B., Neumann, I.D., Thebault, S., Torner, L., Martínez de la Escalera, G., Clapp, C. , Vasoinhibin increases anxiety- and depression-related behaviors. , Psychoneuroendocrinology, junio de 2014; 44, 123-132

100. Garcia, C., Nuñez-Arita, R.E., Thebault, S., Arredondo-Zamarripa, D., Jeziorski, M.C., Martínez de la Escalera, G., Clapp, C. , Requirement of phosphorytable endothelial nitric oxide synthase at Ser-1177 for vasoinhibin-mediated antiangiogenic effects. , Endocrine, febrero de 2014; 45(2), 263-270

101. Arnold, E., Thebault, S., Baeza-Cruz, G., Quintanar-Stephano, A., Condés-Lara, M., Rojas-Piloni, G., Binart, N., Martínez de la Escalera, G., Clapp, C., The hormone prolactin is a novel endogenous trophic factor able to regulate reactive glia and to limit retinal degeneration. , Journal Of Neuroscience, enero de 2014; 34(5), 1868-1878

102. Lajud, N., Gonzalez-Zapien, R., Roque, A., Tinajero, E., Valdez, J.J., Clapp, C., Torner L. , Prolactin administration during early postnatal life decreases hippocampal and olfatory bulb neurogenesis and results in depressive-like behavior in adulthood. , Hormones And Behavior, noviembre de 2013; 64, 781-789

103. Adán, N., Guzmán-Morales, J., Ledesma-Colunga, G., Perales-Canales, S.I., Quintanar-Stephano, A., López-Barrera, F., Méndez, I., Moreno-Carranza, B., Triebel, J., Binart, N., Martínez de la Escalera, G., Thebault, S., Clapp, C. , Prolactin promotes cartilage survival and attenuates inflammation in rheumatoid arthritis. , Journal Of Clinical Investigation, septiembre de 2013; 123(9), 3902-3913

104. Moreno-Carranza, B., Goya-Arce, M., Vega, C., Adán, N., Triebel, J., Lopez-Barrera, F., Quintanar-Stephano, A., Binart, N., Martínez de la Escalera, G., Clapp, C. , Prolactin promotes normal liver growth, survival, and regeneration in rodents: role of Interleukin-6 and Suppressor of Cytokine Signaling-3., AMERICAN JOURNAL OF PHYSIOLOGY: Regulatory, Integrative and Comparative Physiology, septiembre de 2013; 305, 720-726

105. Clapp, C., Martínez de la Escalera, L., Martínez de la Escalera, G. , Prolactin and blood vessels: a comparative endocrinology perspective., General And Comparative Endocrinology, mayo de 2012; 176(3), 336-340

106. Ramírez, M., Wu, Z., Moreno-Carranza, B., Jeziorski, M.C., Arnold, E., Díaz-Lezama, N., Martínez de la Escalera, G., Colosi, P., Clapp, C. , Vasoinhibin gene transfer by Adeno-Associated Virus type 2 protects against VEGF- and diabetes-induced retinal vasopermeability. , Investigative Ophthalmology & Visual Science, noviembre de 2011; 52(11), 8944-8950

107. Triebel, J., Macotela, Y., Martínez de la Escalera, G. and Clapp, C. , Prolactin and Vasoinhibins: endogenous players in diabetic retinopathy. , IUBMB Life, octubre de 2011; 63(10), 806-810

108. Ferraris, J., Radl, G.B., Zárate, S., Jaita, G., Eijo, G., Zaldivar, V., Clapp, C., Seilicovich, A. and Piseraand, D. , N-terminal Prolactin-derived Fragments, Vasoinhibins, are Proapoptoptic and Antiproliferative in the Anterior Pituitary., Plos One, julio de 2011; 6(7), e21806 online

109. Thebault, S., González, C., García, C., Arredondo Zamarripa, D., Nava, G., Vaca, L., Martínez de la Escalera, G. and Clapp, C. , Vasoinhibins prevent bradykinin-stimulated endothelial cell proliferation by inactivating eNOS via reduction of both intracellular Ca2+ levels and eNOS phosphorylation at Ser(1179). , Pharmaceuticals, julio de 2011; 4(7), 1052-1069 online

110. Clapp, C. and Martínez de la Escalera, G. , Editorial Focus: peripheral regulation of prolactin by oxytocin: focus on “systemic oxytocin induces a prolactin secretory rhythm via the pelvic nerve in ovariectomized rats”., AMERICAN JOURNAL OF PHYSIOLOGY: Regulatory, Integrative and Comparative Physiology, marzo de 2011; 301(3), 674-675 online

111. Arnold E, Rivera JC, Thebault S, Moreno-Páramo D, Quiroz-Mercado H, Quintanar-Stéphano A, Binart N, Martínez de la Escalera G, Clapp C. , High levels of serum prolactin protect against diabetic retinopathy by increasing ocular vasoinhibins. , Diabetes, diciembre de 2010; 59(12), 3192-3197

112. Vega C, Moreno-Carranza B, Zamorano M, Quintanar-Stephano A, Méndez I, Thebault S, Martínez de la Escalera G, Clapp C. , Prolactin promotes oxytocin and vasopressin release by activating neuronal nitric oxide synthase in the supraoptic and paraventricular nuclei. , AMERICAN JOURNAL OF PHYSIOLOGY: Regulatory, Integrative and Comparative Physiology, diciembre de 2010; 299(6), 1701-1708

113. Velez-Montoya R, Clapp C, Rivera JC, Garcia-Aguirre G, Morales-Cantón V, Fromow-Guerra J, Guerrero-Naranjo JL, Quiroz-Mercado H. , Intraocular and systemic levels of vascular endothelial growth factor in advanced cases of retinopathy of prematurity., Clinical Ophthalmology, julio de 2010; 4, 947-953

114. Méndez I, Vega C, Zamorano M, Moreno-Carranza B, Martínez de la Escalera G, Clapp C. , Vasoinhibins and the pituitary gland. , Frontiers Of Hormone Research, febrero de 2010; 38, 184-189

115. Castilla, A., García, C., Cruz-Soto, M., Martínez de la Escalera, G., Thebault, S., Clapp, C., Prolactin in ovarian follicular fluid stimulates endothelial cell proliferation., Journal of Vascular Research, enero de 2010; 47(1), 45-53

116. Cruz-Soto, M., Cosío, G., Jeziorski, M.C., Vargas-Barroso, V., Aguilar, M.B., Cárabez, A., Berger, P., Satfig, P., Thebault, S., Martínez de la Escalera, G., Clapp, C. , Cathepsin D is a primary protease for the generation of adenohypophyseal vasoinhibins: Cleavage occurs within the prolactin secretory granules. , Endocrinology, diciembre de 2009; 150(12), 5446-5454

117. Clapp, C., Thebault, S., Jeziorski, M.C., Martínez de la Escalera, G. , Peptide hormone regulation of angiogenesis., Physiological Reviews, octubre de 2009; 89(4), 1177-1215

118. Melo, A.I., Pérez-Ledezma, M., Clapp, C., Rivera, J.C., Fleming, A.S., Arnold, E. , Effects of prolactin deficiency during the early postnatal period on the development of maternal behavior in female rats: Mother’s milk makes the difference. , Hormones And Behavior, enero de 2009; 59(1), 281-291

119. Clapp C, Thebault S, Arnold E, García C, Rivera JC, Martínez de la Escalera G., Vasoinhibins: Novel inhibitors of ocular angiogenesis, American Journal Of Physiology, Endocrinology And Metabolism, octubre de 2008; 295(4), 772-778

120. García, C., Aranda, J., Arnold, E., Thebault, S., Macotela, J., López-Casillas, F., Mendoza, V., Quiroz-Mercado, H., Lin, S.H., Martínez de la Escalera, G., Clapp, C., Vasoinhibins prevent increased retinal vasopermeability associated with diabetic retinopathy via protein phosphatase 2A-dependent eNOS inactivation, Journal Of Clinical Investigation, junio de 2008; 118(6), 2291-2300

121. Rivera, J.C., Aranda, J., Riesgo, J., Nava, G., Thebault, S., López-Barrera, F., Ramírez, M., Martínez de la Escalera, G., Clapp, C, Expression and cellular localization of prolactin and the prolactin receptor in mammalian retina., Experimental Eye Research, junio de 2008; 86(2), 314-321

122. Clapp, C., Thebault, S, Martínez de la Escalera, G., Role of prolactin and vasoinhibins in the regulation of vascular function in mammary gland., Journal Of Mammary Gland Biology And Neoplasia, marzo de 2008; 13(1), 55-67

123. Jacobi, J.S., Martin, C., Nava, G., Jeziorski, M.C., Clapp, C., Martínez de la Escalera, G. , 17β-estradiol directly regulates the expression of adrenergic and kisspeptin receptors in GT1-7 GnRH neurons. , Neuroendocrinology, 2007; 86, 260-269

124. Martin, C., Jacobi J.S., Nava, G., Jeziorski M.C., Clapp, C., Martínez de la Escalera, G. , GABA Inhibition of Cyclic AMP Production in immortalized GnRH neurons is mediated by calcineurin-dependent dephosphorylation of adenylyl cyclase 9. , Neuroendocrinology, 2007; 85, 257-266

125. Clapp C., Thebault S., Martínez de la Escalera G., Hormones and postpartum cardiomyopathy, Trends In Endocrinology And Metabolism, noviembre de 2007; 18(9), 329-330

126. González C., Parra A., Ramírez-Pulido J., García C., Rivera J.C., Macotela Y., Aranda J., Lemini M., Arias J., Ibarguengoitia F., Martínez de la Escalera G., Clapp C., ELEVATED VASOINHIBINS MAY CONTRIBUYE TO ENDOTELIAL CELL DYSFUNCTION AND LOW BIRTH WEIGHT IN PREECLAMPSIA., Laboratory Investigation, enero de 2007; 87(0), 1009-1017

127. Luz-Madrigal A., Clapp C., Aranda J., Vaca L., IN VIVO TRANSCRIPTIONAL TARGETING INTO THE RETINAL VASCULATURE USING RECOMBINANT BACULOVIRUS CARRYING THE HUMAN FLT-1 PROMOTER., Virology Journal, enero de 2007; 4(0), 88-99

128. Moreno-Páramo, D., Rivera, J.C., Aranda, J., Salazar, N., Arnold, E., Quiróz-Mercado, H., Martínez de la Escalera, G., Clapp, C., RETINOPATIA DIABETICA Y VASOINHIBINAS., Revista de Investigacion Clinica, enero de 2007; 19(0), 290-297

129. Quintanar J.L., Salinas E., Guerrero R., Gómez R., Vidal S., Aranda J., Clapp C., PROLACTIN-LIKE HORMONE IN THE NEMATOO TRICHINELLA SPIRALIS LARVAE., Experimental Parasitology, enero de 2007; 116(0), 137-141

130. Macotela, Y., Aguilar, M., Guzmán-Morales, J., Rivera, J.C., Zermeño, C., López-Barrera, F., Nava, G., Lavalle, C., Martínez de la Escalera, G., Clapp, C. , Matrix metalloproteases from chondrocytes generate antiangiogenic 16K-prolactin. , Journal Of Cell Science, 2006; 119, 1790-1800

131. Zermeño, C., Guzmán-Morales, J., Macotela, Y., Nava, G., López-Barrera, F., Kouri, J., Lavalle, C., Martínez de la Escalera, G., and Clapp, C. , Prolactin inhibits the apoptosis of chondrocytes induced by serum-starvation , Journal Of Endocrinology, 2006; 189, 1-8

132. Clapp C, Aranda J, González C, Jeziorski MC, Martínez de la Escalera G, Vasoinhibins: endogenous regulators of angiogenesis and vascular function, Trends In Endocrinology And Metabolism, octubre de 2006; 17(0), 301-307

133. Clapp C, González C, Macotela Y, Aranda J, Rivera JC, García C, Guzmán-Morales J, Zamorano M, Vega C, Martin C, Jeziorski MC, Martínez de la Escalera G, Vasoinhibins: a family of N-terminal prolactin fragments that inhibit angiogenesis and vascular function, Frontiers Of Hormone Research, enero de 2006; 35(0), 64-73

134. Clapp C., Martínez de la Escalera G., AQUAPORIN-1: A NOVEL PROMOTER OF TUMOR ANGIOGENESIS., Trends In Endocrinology And Metabolism, enero de 2006; 17(0), 1-2

135. Gutiérrez de la Barrera M., Trejo B., Luna-Pérez P., López-Barrera F., Martínez de la Escalera G., Clapp C., OPPOSITE ASSOCIATION OF SERUM PROLACTIN AND SURVIVAL IN PATIENTS WITH COLON AND RECTAL CARCINOMAS: INFLUENCE OF PREOPERATIVE RADIOTHERAPY., Digestive Diseases And Sciences, enero de 2006; 51(0), 54-62

136. Aranda J., Rivera J. C., Jeziorski M. C., Riesgo J., Nava G., López-Barrera F., Quiroz-Mercado H., Berger P., Martínez de la Escalera G. and Clapp C, Prolactins are natural inhibitors of angiogenesis in the retina, Investigative Ophthalmology & Visual Science, enero de 2005; 46(0), 2947-2953

137. Montes de Oca P., Macotela Y., Nava G., López-Barrera F., Martínez de la Escalera G., Clapp C., PROLACTIN STIMULATES INTEGRIN-MEDIATED ADHESION OF CIRCULATING MONONUCLEAR CELLS TO ENDOTHELIAL CELLS., Laboratory Investigation, enero de 2005; 85(0), 633-642

138. Gonzalez, C., Corbacho A.M., Eiserich, J.P., Garcia, C., Lopez-Barrera, F., Morales-Tlalpan, V., Barajas-Espinosa, A., Díaz-Muñoz, M., Rubio, R., Lin S-H., Martínez de la Escalera, G., Clapp, C. , 16K-Prolactin inhibits activation of endotelial nitric oxide synthase, intracellular calcium mobilization and endothelium-dependent vasorelaxation, Endocrinology, 2004; 145, 5714-5722

139. Piwnica, D., Touraine P., Struman, I., Tabruyn, S., Bolbach G., Clapp, C., Martial JA., Kelly, P.A., Goffin, V. , Cathepsin-D proceses human prolacitn into a 16K-like N-termina fragments displaying anti-angiogenic properties. , Molecular Endocrinology, octubre de 2004; 18(10), 2522-2542

140. Dueñas Z., Rivera J.C., Quiróz-Mercado H., Aranda J., Macotela Y., Montes de Oca P., López-Barrera F., Nava G., Guerrero J.L., Suárez A., De Regil M., Martínez de la Escalera G., Clapp C., Prolactin in the eye of patients with retinopathy of prematurity: Implications for vascular regression., Investigative Ophthalmology & Visual Science, enero de 2004; 45(7), 2049-2055

141. Torner L., Maloumby R., Nava G., Aranda J., Clapp C., Neumann D.I., In vivo release and gene upregulation of brain prolactin in response to physiological stimuli. , European Journal Of Neuroscience, enero de 2004; 19(0), 1601-1608

142. Corbacho A.M., Macotela Y., Nava G., Eiserich J.P., Cross C.E, Martínez de la Escalera G., Clapp C., CYTOKINE INDUCTION OF PROLACTIN RECEPTORS MEDIATES PROLACTIN INHIBITION OF NITRIC OXIDE SYNTHESIS IN PULMONARY FIBROBLASTS., Febs Letters, enero de 2003; 544(0), 171-174

143. Cosío G, Jeziorski MC, López-Barrera F, Martínez de la Escalera G, Clapp C, Hypoxia inhibits expression of prolactin and secretion of cathepsin-D by the GH4C1 pituitary cell line, Laboratory Investigation, enero de 2003; 83(11), 1627-1636

144. Galfione M., Luo W., Kim J., Hawke D., Kobayashi R., Clapp C., Yu-Lee, L-Y., Lin, S-H. , EXPRESSION AND PURIFICATION OF THE ANGIOGENESIS INHIBITOR 16 KILODALTON PROLACTIN FRAGMENT FROM INSECT CELLS., Protein Expression And Purification, enero de 2003; 28(0), 252-258

145. Mejía S, Torner LM, Jeziorski MC, González C, Morales MA, Martínez de la Escalera G, Clapp C, Prolactin and 16K prolactin stimulate the release of vasopressin by a direct effect on the hypothalamo-neurohypophyseal system, Endocrine, enero de 2003; 20(0), 155-162

146. Cajero-Juárez M., Avila B., Ochoa A., Garrido-Guerrero E., Varela-Echavarría A., Martínez de la Escalera G., Clapp C., Immortalization of bovine umbilical vein endothelial cells: a model for the study of vascular endothelium, European Journal Of Cell Biology, octubre de 2002; 81(0), 1-8

147. Corbacho A.M., Martínez de la Escalera G., Clapp C., ROLES OF PROLACTIN AND RELATED MEMBERS OF THE PROLACTIN/GROWTH HORMONE/PLACENTAL LACTOGEN FAMILY IN ANGIOGENESIS., Journal Of Endocrinology, enero de 2002; 173(0), 219-238

148. Macotela Y., Mendoza C., Cosío G., Eiserich J.P., Zentella A., Martínez de la Escalera G., Clapp C., 16K PROLACTIN INDUCES NF-KB ACTIVATION IN PULMONARY FIBROBLASTS., Journal Of Endocrinology, enero de 2002; 175(0), R13-R18

149. Torner L., Toschi N., Nava G., Clapp C., Neumann D.I., INCREASED HYPOTHALAMIC EXPRESSION OF PROLACTIN IN LACTATION: INVOLVEMENT IN BEHAVIOURAL AND NEUROENDOCRINE STRESS RESPONSES., European Journal Of Neuroscience, enero de 2002; 15(0), 1-11

150. Beltrán-Parrazal, L., Noris, G., Clapp, C., and Martínez de la Escalera, G. , GABA inhibition of immortalized GnRH neuronal excitability involves GABAA receptors negatively coupled to cyclic AMP formation , Endocrine, 2001; 14, 189-195

151. Cruz J., Aviña-Zubieta A., Martínez de la Escalera G., Clapp C., Lavalle C., MOLECULAR HETEROGENEITY OF PROLACTIN IN THE PLASMA OF PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS., Arthritis Rheumatism, enero de 2001; 44(0), 1331-1335

152. Martínez de la Escalera G., Clapp C., REGULATION OF GONADOTROPIN-RELEASING HORMONE SECRETION: LESSONS FROM GT1 IMMORTAL GNRH NEURONS., Archives Of Medical Reseach, enero de 2001; 32(0), 486-498

153. Ochoa A., Montes de Oca P., Rivera J.C., Dueñas Z., Nava G., Martínez de la Escalera G., Clapp C., EXPRESSION OF PROLACTIN GENE AND SECRETION OF PROLACTIN BY RAT RETINAL CAPILLARY ENDOTHELIAL CELLS., Investigative Ophthalmology & Visual Science, enero de 2001; 42(0), 1639-1645

154. Corbacho A.M., Macotela Y., Nava G., Torner L., Dueñas Z., Noris G.F., Morales M.A., Martínez de la Escalera G., Clapp C., HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS EXPRESS MULTIPLE PROLACTIN-LIKE ISOFORMS., Journal Of Endocrinology, enero de 2000; 166(0), 53-62

155. Corbacho A.M., Nava G., Eiserich J.P., Noris G.F., Macotela Y., Struman I., Martínez de la Escalera G., Freeman B.A., Clapp C., PROTEOLYTIC CLEAVAGE CONFERS NITRIC OXIDE SYNTHASE INDUCTING ACTIVITY UPON PROLACTIN., Journal Of Biological Chemistry, enero de 2000; 275(0), 13183-13186

156. Hernández, M.M., García Ferreiro, R.E., García, D.E., Hernández, M.E., Clapp, C. and Martínez de la Escalera, G. , Potentiation of prolactin secretion following lactotrope escape from dopamine action: I. Dopamine withdrawal augments L-type Ca2+ channels , Neuroendocrinology, 1999; 70(1), 20-30

157. Dueñas Z., Torner L., Corbacho Ana. M., Ochoa A., Gutiérrez-Ozpina G., Barrios F., Berger P., Martínez de la Escalera G., Clapp C., INHIBITION OF RAT CORNEAL ANGIOGENESIS BY 16-KDA PROLACTIN AND BY ENDOGENOUS PROLACTIN-LIKE MOLECULES., Investigative Ophthalmology & Visual Science, enero de 1999; 40(11), 2498-2505

158. Hernández M.E., Díaz M., Hernández M.M., Clapp C., Martínez de la Escalera G., Potentiation of prolactin secretion following lactotrope escape from dopamine action. II. Phosphorylation of the α1 subunit of L-type, voltage-dependent calcium channels, Neuroendocrinology, enero de 1999; 70(0), 31-42

159. Torner L., Nava G., Dueñas Z., Corbacho A., Mejía S., López F., Cajero M., Martínez de la Escalera G., Clapp C., CHANGES IN THE EXPRESSION OF NEUROHYPOPHYSEAL PROLACTINS DURING THE ESTROUS CYCLE AND AFTER ESTROGEN TREATMENT., Journal Of Endocrinology, enero de 1999; 161(3), 423-432

160. Trueta C., Díaz M., Vaca L., Clapp C., Martínez de la Escalera G., Functional uncoupling between intracellular calcium dynamics and secretion in the αT3-1 gonadotropic cells, Journal Of Cellular Physiology, enero de 1999; 179(0), 347-357

161. CLAPP, C., LOPEZ-GOMEZ, F., NAVA, G., MACOTELA, Y., TORNER, L., CORBACHO, A., ACOSTA, E., DUEÑAS, Z., MORALES, M.A., MARTINEZ DE LA ESCALERA, G., EXPRESSION OF PROLACTIN mRNA AND PROLACTIN-LIKE PROTEINS IN ENDOTHELIAL CELLS. EVIDENCE FOR AUTOCRINE EFFECTS., Journal Of Endocrinology, enero de 1998; 158(0), 137-144

162. Lee H., Struman I., Clapp C., Martial J.A., Weiner. R. I., INHIBITION OF UROKINASE ACTIVITY BY THE ANTIANGIOGENIC FACTOR 16K PROLACTIN: ACTIVATION OF PLASMINOGEN ACTIVATOR INHIBITOR 1 EXPRESSION., Endocrinology, enero de 1998; 139(0), 3696-3703

163. Clapp C., Martínez de la Escalera G., PROLACTINS: NOVEL REGULATORS OF ANGIOGENESIS., News In Physiological Sciences, enero de 1997; 12(0), 40-46

164. Mejía S., Morales M. A., Zetina M.E., Martínez de la Escalera G., Clapp C., IMMUNOREACTIVE PROLACTINS CO-LOCALIZE WITH VASOPRESSIN IN NEURONS OF THE HYPOTHALAMIC PARAVENTRICULAR AND SUPRAOPTIC NUCLEI., Neuroendocrinology, enero de 1997; 66(0), 151-159

165. Ochoa A., Domenzáin C., Clapp C., Martínez de la Escalera G., DIFFERENTIAL EFFECTS OF BFGF, EGF, TGF-A AND IGF-I ON A HYPOTHALAMIC GNRH NEURONAL CELL LINE., Journal Of Neuroscience Research, enero de 1997; 49(0), 739-749

166. Trueta C., Salgado Z., Clapp C., Martínez de la Escalera G., THE CATECHOLAMINERGIC STIMULATION OF GONADOTROPIN-RELEASING HORMONE RELEASE BY GT1-1 CELLS DOES NOT INVOLVE PHOSPHOINOSITIDE HYDROLYSIS., Life Sciences, enero de 1996; 58(0), 1453-1459

167. López-Gómez, F.J., Torner, L., Mejía, S., Martínez de la Escalera, G. and Clapp, C., Immunoreactive prolactins of the neurohypophyseal system display actions characteristic of prolactin and 16K prolactin. , Endocrine, 1995; 3, 573-578

168. Noris G.F., Hol D., Clapp C., Martínez de la Escalera G., HISTAMINE DIRECTLY STIMULATES GONADOTROPIN RELEASING HORMONE SECRETION FROM GT1-1 CELLS VIA H1 RECEPTORS COUPLED TO PHOSPHOINOSITIDE HYDROLYSIS., Endocrinology, enero de 1995; 137(0), 2967-2974

169. Torner L., Mejía S., López-Gómez F., Quintanar A., Martínez de la Escalera G., Clapp C., A 14 KDA PROLACTINLIKE FRAGMENT IS SECRETED FROM THE HYPOTHALAMONEUROHYPOPHYSEAL SYSTEM OF THE RAT., Endocrinology, enero de 1995; 136(0), 54-60

170. Clapp C., Torner L., Gutiérrez-Ospina G., Alcántara E., López-Gómez F., Nagano M., Kelly P., Mejía S., Morales M., Martínez de la Escalera, G., PROLACTIN GENE IS EXPRESSED IN THE HYPOTHALAMO-NEUROHYPOPHYSEAL SYSTEM AND THE PROTEIN IS PROCESSED INTO A 14 KDA FRAGMENT WITH 16K PROLACTIN-LIKE ACTIVITY., Proceedings Of The National Academy Of Sciences Of The United States Of America, enero de 1994; 91(0), 10384-10388

171. Hernández M.E., Clapp C., Martínez de la Escalera G., DOPAMINE-ESCAPE POTENTIATION OF PROLACTIN RELEASE INVOLVES THE ACTIVATION OF CALCIUM CHANNELS BY PROTEIN KINASES A AND C., Endocrine, enero de 1994; 2(0), 779-786

172. CLAPP, C, MARTIAL, J., RENTIER-DELRUE F., GUZMAN R., WEINER, R.I., THE 16 KDA N-TERMINAL FRAGMENT OF HUMAN PROLACTIN IS A POTENT INHIBITOR OF ANGIOGENESIS., Endocrinology, enero de 1993; 133(0), 1292-1299

173. CLAPP C., WEINER RI., A SPECIFIC, HIGH AFFINITY, SATURABLE BINDING SITE FOR THE 16KDFRAGMENT OF PROLACTIN ON CAPILLARY ENDOTHELIAL CELLS., Endocrinology, enero de 1992; 130(0), 1380-1386

174. MENA F., HUMMELT G., AGUAYO D., CLAPP C., MARTINEZ DE LA ESCALERA G., MORALES M.T. , CHANGES IN MOLECULAR VARIANTS DURING IN VITRO TRANSFORMATION AND RELEASE OF PROLACTIN BY THE PITUITARY GLAND OF THE LACTATING RAT., Endocrinology, enero de 1992; 130(0), 3365-3377

175. FERRARA N., CLAPP C., WEINER RI., THE 16K FRAGMENT OF PROLACTIN SPECIFICALLY INHIBITS BASAL ORFGFSTIMULATED GROWTH OF CAPILLARY ENDOTHELIAL CELLS., Endocrinology, enero de 1991; 129(0), 896-900

176. MENA F., CLAPP C., AGUAYO D., MORALES M.T., MARTINEZ DE LA ESCALERA G., STIMULATORY AND INHIBITORY EFFECTS OF SUCKLING ON MILK SECRETION., Endocrine Regulations, enero de 1991; 25(0), 25-35

177. MENA F., CLAPP C., AGUAYO D, MARTINEZ DE LA ESCALERA G., PROLACTIN AND PROPRANOLOL PREVENT THE SUCKLING INDUCED INHIBITION OF LACTATION IN RABBITS., Physiology And Behavior, enero de 1990; 48(2)(0), 311-315

178. MENA F., CLAPP C., MARTINEZ DE LA ESCALERA, G., AGE RELATED STIMULATORY AND INHIBITORY EFFECTS OF SUCKLING REGULATE LACTATION IN RABBITS., Physiology And Behavior, enero de 1990; 48(0), 307-310

179. CLAPP C, P.S. SEARS, C.S. NICOLL, BINDING STUDIES WITH INTACT RAT PROLACTIN AND A 16K FRAGMENT OF THE HORMONE., Endocrinology, enero de 1989; 125(0), 1054-1059

180. MENA F., CLAPP C., AGUAYO D., MARTINEZ DE LA ESCALERA G., DIFFERENTIAL EFFECTS OF THYROTROPIN RELEASING HORMONE ON IN VITRO RELEASE OF IN VIVO OR IN VITRO NEWLY SINTHETIZED AND MATURE PROLACTIN BY LACTATING RAT ADENOHYPOPHYSESFURTHER EVIDEN., Neuroendocrinology, enero de 1989; 49(0), 207-214

181. MENA F, CLAPP C. AGUAYO D, MORALES MT. GROSVENOR CE, MARTINEZ DE LA ESCALERA G., REGULATION OF PROLACTIN SECRETION BY DOPAMINE AND THYROTROPINRELEASING HORMONE IN LACTATING RAT ADENOHYPOPHYSESINFLUENCE OF INTRACELLULAR AGE OF THE HORMONE., Endocrinology, enero de 1989; 125(0), 1814-1820

182. CLAPP C., P.S. SEARS, D.H. RUSSELL, J. RICHARDS, B.K. LEVAYYOUNGY C.S.NICOLL., BIOLOGICAL AND IMMUNOLOGICAL CHARACTERIZATION OF CLEAVED AND16K FORMS OF RAT PROLACTIN., Endocrinology, enero de 1988; 122(0), 2892-2899

183. CLAPP C., ANALYSIS OF THE PROTEOLYTIC CLEAVAGE OF PROLACTIN BY THE MAMMARY GLANDAND LIVER OF THE RAT. CHARACTERIZATION OF THE CLEAVED AND 16K FORMS., Endocrinology, enero de 1987; 121(0), 2055-2064

184. CLAPP C, MARTINEZ DE LA ESCALERA G, AGUAYO D, MENA F., REGULACION INTEGRATIVA DE LA LACTANCIA., Bol. Estud. Med. Biol. Méx, enero de 1987; 35(0), 63-107

185. MENA F., MARTINEZ DE LA ESCALERA G., CLAPP C., AGUAYO D., MORALES M.T., GROSVENOR C.E., INVESTIGATION INTO THE ROLE OF DOPAMINE AND LYSOSOMES IN THE IMPAIRMENT OF PROLACTIN TRANSFORMATION AND RELEASE IMPOSED BY LONG PERIODS OF NON-SUCKLING IN THE RAT., Acta Endocrinologica, enero de 1987; 114(0), 371-378

186. MARTINEZ DE LA ESCALERA G., CLAPP C., MORALES M.T., LORENSON M.Y., MENA F., REVERSAL BY THIOLS OF DOPAMINE-, STALK-MEDIAN EMINENCE- AND ZINC-INDUCED INHIBITION OF PROLACTIN TRANSFORMATION IN ADENOHYPOPHYSES OF LACTATING RATS., Endocrinology, enero de 1986; 118(0), 1803-1807

187. MENA F., CLAPP C., AGUAYO D., LORENSON M.Y., MARTINEZ DE LA ESCALERA G., THIOL REGULATION OF DEPLETION-TRANSFORMATION AND RELEASE OF PROLACTIN BY THE PITUITARY OF THE LACTATING RAT., Endocrinology, enero de 1986; 118(0), 1795-1802

188. CLAPP C, MARTINEZ DE LA ESCALERA G, MORALES MT, SHYR SW, GROSVENOR CE, MENA F., RELEASE OF CATECHOLAMINES FOLLOWS SUCKLING OR ELECTRICAL STIMULATION OF MAMMARY NERVE IN LACTATING RATS., Endocrinology, enero de 1985; 117(0), 2498-2503

189. MENA F, MARTINEZ DE LA ESCALERA G, CLAPP C, GROSVENOR C., IN VIVO AND IN VITRO SECRETION OF PROLACTIN BY LACTATING RAT ADENOHYPOPHYSES AS A FUNCTION OF INTRACELLULAR AGE., Journal Of Endocrinology, enero de 1984; 101(0), 27-32

190. CLAPP, C. Y F. MENA, CONTROL NEUROENDOCRINO DE LA EVALUACION LACTEA EN LA RATA., Instituto De Estudios Médicos Y Biologicos México, enero de 1982; 32(0), 119-155

191. MENA F., G. MARTINEZ DE LA ESCALERA, D. AGUAYO, C. CLAPP Y C.E. GROSVENOR., LATENCY AND DURATION OF THE EFFECTS OF BROMOCRIPTINE AND PROLACTIN ON MILK SECRETION IN LACTATING RABBITS., Journal Of Endocrinology, enero de 1982; 94(0), 389-395

192. MENA, F., MARTINEZ DE LA ESCALERA G., CLAPP C., AGUAYO D., FORRAY C., GROSVENOR C.E., A SOLUBILITY SHIFT OCCURS DURING DEPLETION TRANSFORMATION OF PROLACTIN WITHIN THE LACTATING RAT PITUITARY., Endocrinology, enero de 1982; 111(0), 1086-1091

193. MENA F, MARTINEZ DE LA ESCALERA G, CLAPP C, AGUAYO D, ANGUIANO G, GROSVENOR CE, EFFECT OF ACUTE INCREASE IN SUCKLING FREQUENCY UPON FOOD INTAKE AND MILK SECRETION IN THE RABBIT., Proceedings Of The Society For Experimental Biology And Medicine, enero de 1981; 168(0), 373-377

194. MENA F, P. PACHECO, D. AGUAYO, C. CLAPP Y C.E. GROSVENOR., A RISE IN INTRAMAMMARY PRESSURE FOLLOWS ELECTRICAL STIMULATION OF MAMMARY NERVE IN ANESTHETIZED RATS., Endocrinology, enero de 1978; 104(0), 751-757

Ultimas tesis dirigidas

1. José Manuel Bahena Sánchez. (estudiante), Análisis del efecto protector de la vasoinhibina sobre la adhesión y migración transendotelial de células de melanoma B16F10, Modalidad: Tesis, Maestría en Ciencias (Neurobiolgía), Maestría, Instituto de Neurobiología, Universidad Nacional Autonoma de Mexico, Fecha de presentación de examen: 07/10/2025, Clapp Jiménez L María del Carmen (Director)

2. Daniela Granados Carrasco. (estudiante), Análisis del efecto protector de la administración en gotas oftálmicas de CRIVi45-51 en modelos experimentales de edema macular diabético., Modalidad: Tesis, Maestría en Ciencias (Neurobiolgía), Maestría, Instituto de Neurobiología, Universidad Nacional Autonoma de Mexico, Fecha de presentación de examen: 29/08/2025, Clapp Jiménez L María del Carmen (Director)

3. Alma Lorena Pérez Gómez (estudiante), Análisis del efecto antiangiogénico de oligopéptidos análogos a la vasoinhibina en un modelo murino de melanoma, Modalidad: Tesis, Doctorado en Ciencias Biomédicas , Doctorado, INB, Universidad Nacional Autonoma de Mexico, Fecha de presentación de examen: 05/08/2025, Clapp Jiménez L María del Carmen (Director)

4. Francisco Freinet Núñez Ramírez. (estudiante), Análisis de la participación del eje prolactina/vasoinhibina en la vascularización de la retina de ratones neonatos, Modalidad: Tesis, Doctorado en Ciencias Biomédicas, Doctorado, Instituto de Neurobiología, Universidad Nacional Autonoma de Mexico, Fecha de presentación de examen: 12/06/2025, Clapp Jiménez L María del Carmen (Director)

5. José Fernando García Rodrigo. (estudiante), Efectos duales de la prolactina sobre la respuesta inflamatoria de tejidos de la articulación. , Modalidad: Tesis, Doctorado en Ciencias Biomédicas, Doctorado, Instituto de Neurobiología, Universidad Nacional Autonoma de Mexico, Fecha de presentación de examen: 14/05/2024, Clapp Jiménez L María del Carmen (Director)

Capítulos en libros recientes

1. Hector Mayani (Ed.), Paralelo 21, Ciencia y Vida: Historias y Reflexiones de Científicas y Científicos Mexicanos, , Hector Mayani (Ed.), Paralelo 21. , , México, ISBN: 9786077891611, febrero de 2023

2. Clapp, C., Martínez de la Escalera, G. , Fisiología eLibro. Facultad de Medicina, Universidad Nacional Autónoma de México, México., , 1, , México, agosto de 2017

3. Clapp, C., Martínez de la Escalera, G. , Behavioral Neuroendocrinology. Komisaruk, B., González-Mariscal, G. (Eds.), CRC Press, London, England , , 1, , Reino Unido, ISBN: ISBN 9-78149-8731-911, febrero de 2017

4. Moreno-Carranza B, Méndez I, Martínez de la Escalera G, Clapp C. , Endocrinología Reproductiva, , 1a, , México, ISBN: 970-9793-18-7, 2009

5. Martínez de la Escalera, G., Clapp, C., APORTACIONES CIENTIFICAS Y HUMANISTICAS MEXICANAS EN EL SIGLO XX, , 1a, , México, ISBN: 978-968-16-8634-5 , 2008