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Research Interest
Most Recent Publications
Most Recent Advised Theses
Most Recent Chapters in Books
Dra. María Isabel Miranda Saucedo
Investigador Tit. B T.C.
mirandami@unam.mx

Instituto de Neurobiología - Laboratorio B-14, Instituto de Neurobiología - UNAM, Boulevard Juriquilla 3001, Juriquilla, Querétaro, México, C.P. 76230, Querétaro, México

phone: 52 (55) 5623 40 39, (442) 238 10 39   extensión: UNAM 34039
fax: +52 (55) (442) 2381046


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http://mirandalab.net/

SCIENTIFIC RESEARCH
NEUROCHEMISTRY OF MEMORY LABORATORY

“Learning and memory are part of the very foundation of our lives. We tend to think of memory as involving only our past, but in fact, it is memory that allows us to use past experience to think, reason and plan for the future – without memory the continuity between past, present and future that we take for granted is lost”. CNLM at UCI.

My work is to investigate memory at neurochemical brain systems level trying to contribute to the question of how we learn and remember; my main research topics are:

FORMATION OF AVERSIVE AND INCIDENTAL MEMORIES: CORTICAL, LIMBIC AND BASAL BRAIN INTERACTIONS: Our research is aimed at gaining knowledge about the mechanisms of chemical communication between brain structures that interact during aversive memory formation, as well as those without an evident emotional component, by using non-associative and associative taste and context learning models and manipulating the different structures involved in forming and retrieving memory. Behavioral, pharmacological and neurochemical findings to date indicate that complex structural and chemical interactions between cortical, basal and limbic areas of the brain occur during the acquisition, consolidation and evocation of memories. These studies are helping to better understand the similarities and differences in how memories of different types and strengths are processed.

NEUROBIOLOGICAL SUBSTRATES OF COMPULSIVE CONSUMPTION: Based on the knowledge that some of the brain structures involved in drug rewards also participate during taste memory formation, we are evaluating the changes induced in behavior, brain structures and their chemical interactions, after chronic sugar consumption. This research seeks to understand the changes induced during long-term appetitive memory after chronic exposure to sugar and the effect during new taste learning and re-learning.

Research Interest

Most Recent Publications

1. Rodríguez-García G., Miranda MI., Opposing roles of cholinergic and GABAergic activity in the insular cortex and nucleus basalis magnocellularis during novel recognition and familiar taste memory retrieval, Journal Of Neuroscience, February 2016; 36(6), 1879-89 online

2. Núñez-Jaramillo L, Reyes-López J, Miranda MI., Sodium butyrate into the insular cortex during conditioned taste-aversion acquisition delays aversive taste memory extinction, Neuroreport, April 2014; 25(6), 386-90 online

3. Purón-Sierra L, Miranda MI., Histaminergic modulation of cholinergic release from the nucleus basalis magnocellularis into insular cortex during taste aversive memory formation, Plos One, March 2014; 13(9(3)), e91120 online

4. García-Medina NE., Vera G., Miranda MI., Chemical stimulation or glutamate injections in the nucleus of solitary tract enhance conditioned taste aversion, Behavioural Brain Research, December 2015; 1(278), 202-9 online

5. Valdés-Fuentes M, Vera-Rivera G, De Ita-Pérez D, Méndez I, Miranda MI, Díaz-Muñoz M. , Effect of daytime-restricted feeding in the daily variations of liver metabolism and blood transport of serotonin in rat, Physiol Rep., May 2015; 3(5), 1-10 online

...more

Most Recent Advised Theses

1. Gabriela Rodríguez García (estudiante), Interacción GABAérgica y colinérgica entre el núcleo basal magnocelular y la corteza insular durante el reconocimiento del sabor novedoso y familiar, Modalidad: Tesis, Doctorado en Ciencias Biomédicas, Doctorado, Instituto de Neurobiología UNAM-Juriquilla, Instituto de Neurobiologia, Fecha de presentación de examen: 2017-02-28, Miranda Saucedo María Isabel (Director)

2. Mariana Denisse Vergel Munguia (estudiante), Modulación de la actividad colinérgica en el EL núcleo accumbens durante la formación y evocación de la memoria al sabor, Modalidad: Tesis, Biología, Licenciatura, Biología, Universidad Autónoma de Puebla, Universidad Autónoma de Puebla, Fecha de presentación de examen: 2016-01-19, Miranda Saucedo María Isabel (Director)

3. Raúl Sánchez Hernández (estudiante), Regulación de la motivación y deprivación de ingesta de líquidos durante la formación y evocación de la memoria apetitiva, Modalidad: Tesis, Biología, Licenciatura, Escuela de Biología, Universidad Autónoma de Puebla, Fecha de presentación de examen: 2016-01-15, Miranda Saucedo María Isabel (Director)

4. Liliana Purón Sierra (estudiante), Interacciones histaminérgicas y colinérgicas en el núcleo basal magnocelular y la corteza insular durante la formación de la memoria al sabor aversivo, Modalidad: Tesis, Doctorado en Ciencias Biomédicas, Doctorado, Instituto de Neurobiología UNAM-Juriquilla, Fecha de presentación de examen: 2014-10-10, Miranda Saucedo María Isabel (Director)

5. Daniela Julia Fregoso Urrutia (estudiante), Efecto del consumo crónico de sabores dulces sobre la formación de la memoria gustativa: Función de la actividad colinérgica cortical, Modalidad: Tesis, Maestría en Ciencias, Neurobiología, Maestría, Instituto de Neurobiología UNAM-Juriquilla, Fecha de presentación de examen: 2014-04-30, Miranda Saucedo María Isabel (Director)

Most Recent Chapters in Books

1. Miranda M.I. , Neurobiology of Memory: From genes to brain imaging, 1, 1a, , Estados Unidos de América, ISBN: 0-8493-9070-2, February 2007

2. Bermúdez-Rattoni F., Escobar M.L., Piña A.L., Jiménez N. and Miranda M.I., Avances en la restauración del Sistema Nervioso, , 1a, , México, 1994