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http://mirandalab.net/

SCIENTIFIC RESEARCH
NEUROCHEMISTRY OF MEMORY LABORATORY

“Learning and memory are part of the very foundation of our lives. We tend to think of memory as involving only our past, but in fact, it is memory that allows us to use past experience to think, reason and plan for the future – without memory the continuity between past, present and future that we take for granted is lost”. CNLM at UCI.

My work is to investigate memory at neurochemical brain systems level trying to contribute to the question of how we learn and remember; my main research topics are:

• FORMATION OF AVERSIVE AND INCIDENTAL MEMORIES: CORTICAL, LIMBIC AND BASAL BRAIN INTERACTIONS: Our research is aimed at gaining knowledge about the mechanisms of chemical communication between brain structures that interact during aversive memory formation, as well as those without an evident emotional component, by using non-associative and associative taste and context learning models and manipulating the different structures involved in forming and retrieving memory. Behavioral, pharmacological and neurochemical findings to date indicate that complex structural and chemical interactions between cortical, basal and limbic areas of the brain occur during the acquisition, consolidation and evocation of memories. These studies are helping to better understand the similarities and differences in how memories of different types and strengths are processed.

• NEUROBIOLOGICAL SUBSTRATES OF COMPULSIVE CONSUMPTION: Based on the knowledge that some of the brain structures involved in drug rewards also participate during taste memory formation, we are evaluating the changes induced in behavior, brain structures and their chemical interactions, after chronic sugar consumption. This research seeks to understand the changes induced during long-term appetitive memory after chronic exposure to sugar and the effect during new taste learning and re-learning.

Research Interest

The insular cortex, habenula, lateral hypothalamus and prefrontal cortex as regulatory areas between preference and aversion.

Most Recent Publications

1. Reséndiz-Flores M, Miranda MI. , Sugar consumption induces the consummatory suppression of sugary ethanol: Differential effects of sugar restriction according to sex and age, Drug and Alcohol Dependence, December 2024; 1(260), 7 online

2. Miranda MI, Alcalá A. , Histamine H3 receptor activation in the insular cortex during taste memory conditioning decreases appetitive response but accelerates aversive memory extinction under an ad libitum liquid regimen, Neuroscience, August 2024; 1(559), 7 online

3. Miranda MI, Alcalá A, Vera-Rivera G, Rangel-Hernández JA., Differential effects of thirst and satiety on conditioned taste aversion acquisition, retrieval, and memory extinction, Physiology & Behavior, December 2023; 1(265), 114143 online

4. Osorio-Gómez D, Miranda MI, Guzmán-Ramos K, Bermúdez-Rattoni F., Transforming experiences: Neurobiology of memory updating/editing, Frontiers in Systems Neuroscience, February 2023; 21(17), 7 online

5. Olvera MJ, Miranda MI, Differential Effects of N-methyl-D-aspartate Receptors Activation in the Insular Cortex during Memory Formation and Updating of a Motivational Conflict Task, Neuroscience, August 2022; 10(497), 39-52 online

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Publicaciones

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1. Reséndiz-Flores M, Miranda MI. , Sugar consumption induces the consummatory suppression of sugary ethanol: Differential effects of sugar restriction according to sex and age, Drug and Alcohol Dependence, December 2024; 1(260), 7 online

2. Miranda MI, Alcalá A. , Histamine H3 receptor activation in the insular cortex during taste memory conditioning decreases appetitive response but accelerates aversive memory extinction under an ad libitum liquid regimen, Neuroscience, August 2024; 1(559), 7 online

3. Miranda MI, Alcalá A, Vera-Rivera G, Rangel-Hernández JA., Differential effects of thirst and satiety on conditioned taste aversion acquisition, retrieval, and memory extinction, Physiology & Behavior, December 2023; 1(265), 114143 online

4. Osorio-Gómez D, Miranda MI, Guzmán-Ramos K, Bermúdez-Rattoni F., Transforming experiences: Neurobiology of memory updating/editing, Frontiers in Systems Neuroscience, February 2023; 21(17), 7 online

5. Olvera MJ, Miranda MI, Differential Effects of N-methyl-D-aspartate Receptors Activation in the Insular Cortex during Memory Formation and Updating of a Motivational Conflict Task, Neuroscience, August 2022; 10(497), 39-52 online

6. Miranda MI, Rangel-Hernández A, Vera-Rivera G, Cortes C, Eguibar JR., Taste association capabilities differ in high- and low-yawning rats versus outbred Sprague-Dawley rats after prolonged sugar consumption, Animal Cognition, July 2020; (7), 8 online

7. Miranda MI*, Rangel-Hernández, A., Vera-Rivera, G., García-Medina N., Soto G., Rodríguez-García G., Núñez-Jaramillo L. , The role of dopamine D2 receptors in the nucleus accumbens during taste aversive learning and memory extinction after long-term sugar consumption. , Neuroscience, September 2017; 17(359), 142-150 online

8. Rodríguez-García G., Miranda MI., Opposing roles of cholinergic and GABAergic activity in the insular cortex and nucleus basalis magnocellularis during novel recognition and familiar taste memory retrieval, Journal Of Neuroscience, February 2016; 36(6), 1879-89 online

9. Núñez-Jaramillo L, Reyes-López J, Miranda MI., Sodium butyrate into the insular cortex during conditioned taste-aversion acquisition delays aversive taste memory extinction, Neuroreport, April 2014; 25(6), 386-90 online

10. Purón-Sierra L, Miranda MI., Histaminergic modulation of cholinergic release from the nucleus basalis magnocellularis into insular cortex during taste aversive memory formation, Plos One, March 2014; 13(9(3)), e91120 online

11. Grijalva LE, Miranda MI, Paredes RG., Differential changes in GAP-43 or synaptophysin during appetitive and aversive taste memory formation, Behavioural Brain Resaerch, September 2020; 15(397), 7 online

12. Olvera MJ, Miranda MI., Specific inter-stimulus interval effect of NMDA receptor activation in the insular cortex during conditioned taste aversion, Neurobiology of Learning and Memory, October 2019; 164, 1-4 online

13. Caynas-Rojas S, Rodríguez-García G, Delint-Ramírez I, Miranda MI., Differential function of medial prefrontal cortex catecholaminergic receptors after long-term sugar consumption, Behavioural Brain Research, December 2018; 1(356), 495-503 online

14. Vera-Rivera G, Miranda MI, Rangel-Hernández JA, Badillo-Juárez D, Fregoso-Urrutia D, Caynas-Rojas S. , Effects of caloric or non-caloric sweetener long-term consumption on taste preferences and new aversive learning, Nutritional Neuroscience, December 2018; 4, 1-12 online

15. García-Medina NE., Vera G., Miranda MI., Chemical stimulation or glutamate injections in the nucleus of solitary tract enhance conditioned taste aversion, Behavioural Brain Research, December 2015; 1(278), 202-9 online

16. Valdés-Fuentes M, Vera-Rivera G, De Ita-Pérez D, Méndez I, Miranda MI, Díaz-Muñoz M. , Effect of daytime-restricted feeding in the daily variations of liver metabolism and blood transport of serotonin in rat, Physiol Rep., May 2015; 3(5), 1-10 online

17. Vázquez-Martínez O, Ita-Pérez DD, Valdés-Fuentes M, Flores-Vidrio A, Vera-Rivera G, Miranda MI, Méndez I, Díaz-Muñoz M., Molecular and biochemical modifications of liver glutamine synthetase elicited by daytime restricted feeding, Liver International, December 2014; 34(9), 1391-401 online

18. García-Medina N.E. Miranda M.I.*, Nucleus of the solitary tract chemical stimulation induces extracellular norepinephrine release in the lateral and basolateral amygdala., Brain Stimulation, March 2013; 6(2), 198-201 online

19. Miranda M.I. , Taste and odor memory recognition: The emotional flavor of life. , Reviews in the Neurosciences, December 2012; 23(5-9), 481-499 online

20. Núñez-Jaramillo L. Rangel-Hernández J.A. Burgueño-Zúñiga B. Miranda M.I.* , Activation of nucleus accumbens NMDA receptors differentially affects appetitive or aversive taste learning and memory., Frontiers in Behavioral Neuroscience, April 2012; 6(13), 1-7 online

21. Miranda M.I. , Comiendo compulsivamente: algunas teorías para explicar por qué “no puedes comer sólo una” , Revista Digital Universitaria, March 2012; 13(3), 1-12 online

22. Miranda M.I. González-Cedillo F.J., Díaz-Muñoz M., Intracellular calcium chelation and pharmacological SERCA inhibition of Ca2+ pump in the insular cortex differentially affect taste aversive memory formation and retrieval, Neurobiology Of Learning And Memory, September 2011; 96(2), 96(2):192-8 online

23. Miranda M.I., Sabath E. and Núñez-Jaramillo L., Beta-Adrenergic receptors in the insular cortex are differentially involved during aversive or incidental context memory formation, Learning And Memory, July 2011; 18(8), 502-7 online

24. M.I. Miranda, El sabor de los recuerdos: formación de la memoria gustativa, Revista Digital Universitaria, March 2011; 12(3), 1-15 online

25. Núñez-Jaramillo L., Ramírez-Lugo L., Herrera-Morales W. and Miranda M.I., Taste memory formation: Latest advances and challenges, Behavioural Brain Research, March 2010; 207(2), 232-248 online

26. Reyes-López J, Nuñez-Jaramillo L, Morán-Guel E, Miranda MI., Differential effects of beta-adrenergic receptor blockade in the medial prefrontal cortex during aversive and incidental taste memory formation, Neuroscience, March 2010; 207(2), 195-202 online

27. Purón-Sierra L., Sabath E., Nuñez-Jaramillo L. and Miranda M.I., Blockade of nucleus basalis magnocellularis or activation of insular cortex histamine receptors disrupt formation but not retrieval of taste aversive memory, Neurobiology Of Learning And Memory, February 2010; 93(132), 216-220 online

28. Miranda M.I., Ortiz-Godina, F and Garcia D., Differential involvement of cholinergic and beta-adrenergic systems during acquisition, consolidation, and retrieval of long-term memory of social and neutral odors, Behavioural Brain Research, August 2009; (202(1)), 19-25 online

29. Miranda M.I., Quirarte G.L., Rodriguez-Garcia G., McGaugh J.L. and Roozendaal B., Glucocorticoids enhance taste aversion memory via actions in the insular cortex and basolateral amygdala, Learning And Memory, July 2008; 15(7), 468-476

30. Miranda M.I., Rodríguez-García G., Reyes-López J.V., Ferry B. and Ferreira G., Differential effects of -adrenergic receptors blockade in basolateral amygdala or insular cortex on incidental and aversive taste learning, Neurobiology Of Learning And Memory, January 2008; 90(1), 54-61

31. Miranda M.I. and Bermúdez-Rattoni F., Cholinergic activity in the insular cortex is necessary for acquisition and consolidation of contextual memory, Neurobiology Of Learning And Memory, January 2007; 87(0), 343-351

32. Miranda M.I., Ferry B. amd Ferreira G., Basolateral amygdala noradrenergic activity is involved in the acquisition of conditioned odor aversion in the rat, Neurobiology Of Learning And Memory, January 2007; 88(0), 260-263

33. Ferreira G., Miranda M.I., De la Cruz V., Rodríguez-Ortiz C.J. and Bermúdez-Rattoni F., Basolateral amygdala glutamatergic activation enhances taste aversion through NMDA receptor activation in the insular cortex, European Journal Of Neuroscience, January 2005; 22(0), 2596-2604

34. Bermúdez-Rattoni F, Ramírez-lugo L,Gutiérrez R. and Miranda M.I., Molecular signals into the insular cortex and amygdala during aversive gustatory memory formation, Cellular And Molecular Neurobiology, January 2004; 24(0), 25-36

35. Miranda M.I. and McGaugh J.L., Enhancement of inhibitory avoidance and conditioned taste aversion memory with insular cortex infusions of 8-Br-cAMP or oxotremorine is disrupted by propranolol infusions into the basolateral amygdala, Learning And Memory, January 2004; 11(0), 312-317 online

36. Miranda, M.I., Ferreira G., Ramírez-Lugo L. and Bermúdez-Rattoni F., Role of cholinergic system on the construction of memories: Taste memory encoding, Neurobiology Of Learning And Memory, January 2003; 80(0), 211-222

37. Miranda M.I., LaLumiere R.T., Buen T.V., Bermudez-Rattoni F. and McGaugh J.L., Blockade of noradrenergic receptors in the basolateral amygdala impairs taste memory, European Journal Of Neuroscience, January 2003; 18(0), 2605-2610

38. Ramirez-Lugo L., Miranda M.I, Escobar M.L., Espinosa E. and Bermúdez-Rattoni F., The role of cortical cholinergic pre- post-synaptic receptors in taste memory formation, Neurobiology Of Learning And Memory, January 2003; 79(0), 184-193

39. Miranda M.I., Ferreira G., Ramírez-Lugo L. and Bermúdez-Rattoni F., Glutamatergic activity in the amygdala signals visceral input during taste memory formation, Proceedings Of The National Academy Of Sciences Of The United States Of America, January 2002; 99(0), 11417-11422 online

40. Morón I., Ramírez-Lugo L., Ballesteros M.A., Gutiérrez R., Miranda M.I., Gallo M. and Bermúdez-Rattoni F., Differential Effects of bicuculine and muscimol microinjections into the nucleus basalis magnocellularis in taste and place aversive memory formation, Behavioural Brain Research, January 2002; 134(0), 425-431

41. González C. L. R., Miranda M.I., Gutiérrez H., Ormsby C. and Bermúdez Rattoni F., Differential participation of the NBM in the acquisition and retrieval of conditioned taste aversion and Morris water maze, Behavioural Brain Research, January 2000; 116(0), 88-98

42. Miranda M.I., Ramírez-Lugo L. and Bermúdez-Rattoni F., Cortical cholinergic activity is related to the novelty of the stimulus, European Journal Of Neuroscience, January 2000; 882(0), 230-235

43. Galarraga E., Hernández-López S., Reyes A., Miranda M.I., Bermúdez-Rattoni F., Vilchis C. and Bargas J., Cholinergic modulation of neostriatal output: A functional antagonism between different types of muscarinic receptors, Journal Of Neuroscience, January 1999; 19(0), 3629-3638

44. Gutiérrez H. , Gutiérrez R., Silva-Gandarias R., Estrada J., Miranda, M. I. and Bermúdez-Rattoni F., Differential effects of 192IgG-saporin and NMDA-induced lesions into the basal forebrain on cholinergic activity and taste aversion memory formation, Brain Research, January 1999; 834(0), 136-141

45. Gutiérrez H. Ramírez-Trejo L., Silva-Gandarias R., Ormsby C.E., Miranda M.I. and Bermúdez-Rattoni F., Redundant basal forebrain modulation in taste aversion memory formation, Journal Of Neuroscience, January 1999; 19(0), 7661-7669

46. Miranda M.I. and Bermúdez-Rattoni F., Reversible inactivation of the nucleus basalis magnocellularis induces disruption of cortical acetylcholine release and acquisition, but not retrieval, of aversive memories, Proceedings Of The National Academy Of Sciences Of The United States Of America, January 1999; 96(0), 6478-6482 online

47. Miranda M.I. and Bermúdez-Rattoni F., Acetylcholine determination of microdialysates of fetal neocortex grafts that induce recovery of learning, Brain Research Protocols, January 1998; 2(0), 215-222

48. Gutierrez H., MirandaM.I. and Bermúdez-Rattoni F., Learning impairment and cholinergic deafferentation after cortical NGF deprivation, Journal Of Neuroscience, January 1997; 17(0), 3796-3803

49. Miranda M.I., López-Colomé A.M. and Bermúdez-Rattoni F., Recovery of taste aversion learning Induced by fetal neocortex grafts: Correlation with in vivo extracellular acetylcholine, Brain Research, January 1997; 759(0), 141-148

50. Piña A.L., Ormsby C.E., Miranda M.I., Jiménez N., Tapia R. and Bermúdez-Rattoni F., Graft-induced recovery of inhibitory avoidance conditioning in striatal lesioned rats is related with choline acetiltransferase activity, Journal Of Neural Transplantation And Plasticity, January 1994; 5(0), 11-16

51. Fernández-Ruiz J. Guzmán R., Martínez M.D., Miranda M.I., Bermúdez-Rattoni F. and Drucker-Colín R., Adrenal medullary grafts restore olfactory deficits and catecholamine levels of 6-OHDA amygdala lesioned animals, Journal Of Neural Transplantation And Plasticity, January 1993; 4(0), 121-134

52. Fernández-Ruiz J., Guzmán R., Martínez M.D., Miranda M.I., Bermúdez-Rattoni F. and Drucker-Colín R., Effects of catecholaminergic depletion of the amygdala and insular cortex on the potentiation of odor by taste aversions, Behavioral And Neural Biology, January 1993; 60(0), 189-191

53. Miranda M.I. and Brailowsky S., Plasticidad sináptica y transplantes cerebrales, Revista De La Facultad De Medicina, Unam, January 1992; 35(0), 108-114

Most Recent Advised Theses

1. Imelda Ivett Moreno Manzanares (estudiante), Influencia del estrés durante el consumo y posteriores aprendizajes del sabor dulce , Modalidad: Tesis, Maestria en Ciencias - Neurobiología, Maestría, INB, Universidad Nacional Autónoma de México, Fecha de presentación de examen: 2024-05-16, Miranda Saucedo María Isabel (Director)

2. Jonathan José Gutiérrez Ledezma (estudiante), Validación, montaje y estandarización de la concentración mínima detectable de histamina por HPLC-fluorescencia en dializados de ratas en libre movimiento, Modalidad: Tesis, Licenciatura de Neurociencias, Licenciatura, Escuela Nacional de Estudios Superiores - Unidad Juriquilla, Universidad Nacional Autónoma de México, Fecha de presentación de examen: 2023-08-04, Miranda Saucedo María Isabel (Director)

3. Diana Lizeth Romero Rodríguez (estudiante), Cuantificación de dopamina en la corteza prefrontal durante el consumo prolongado de sacarosa en ratas en libre movimiento, Modalidad: Otra modalidad, Licenciatura en Neurociencias, Licenciatura, Escuela Nacional de Estudios Superiores - Unidad Juriquilla, Universidad Nacional Autónoma de México, Fecha de presentación de examen: 2023-05-01, Miranda Saucedo María Isabel (Director)

4. Jocelyn Lucero Lomelin (estudiante), Participación de la habénula lateral durante la formación de la memoria de aversión al azúcar, así como después de la familiarización a este sabor, Modalidad: Tesis, Maestria en Ciencias Neurobiología, Maestría, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Fecha de presentación de examen: 2023-03-08, Miranda Saucedo María Isabel (Director)

5. Estafania Garcia Siciliano (estudiante), Cambios de la actividad colinérgica en el núcleo accumbens inducidos por el consumo crónico de azúcar, Modalidad: Tesis, Química Farmacéutica Bióloga, Licenciatura, Facultad de Química, Universidad Autonoma de Queretaro, Fecha de presentación de examen: 2021-09-03, Miranda Saucedo María Isabel (Director)

Most Recent Chapters in Books

1. Osorio-Gómez D., Miranda M.I., Bermúdez-Rattoni F., and Guzmán-Ramos K, The SAGE Handbook of Cognitive and Systems Neuroscience, 1, 1017514, , Reino Unido, October 2022

2. 48. Miranda M.I., Guzmán-Ramos K., Osorio-Gómez D., Bermúdez-Rattoni F, The SAGE Handbook of Cognitive and Systems Neuroscience, 1, 1017514, , Reino Unido, October 2022

3. Miranda M.I. , Neurobiology of Memory: From genes to brain imaging, 1, 1a, , Estados Unidos de América, ISBN: 0-8493-9070-2, February 2007

4. Bermúdez-Rattoni F., Escobar M.L., Piña A.L., Jiménez N. and Miranda M.I., Avances en la restauración del Sistema Nervioso, , 1a, , México, 1994