Plataforma de Información Curricular

Research Interest

Cellular and molecular mechanisms of neuron-oligodendrocyte communication. Brain functions are the result of multiple intercellular communication processes. Myelination of axons is one of the fundamental phenomena that allow communication in the nervous system. Through myelination, the axons of the central nervous system are wrapped by myelin-producing oligodendrocytes. This envelope protects and promotes the survival of neurons. Its structure also allows the generation of specialized membrane domains, which modify the biophysical characteristics of the axon, in such a way that it allows the rapid propagation of the nervous impulse. Failure in the formation of myelin has serious consequences on brain functions, this is what happens in several pathologies that together are called demyelinating diseases. Recently, in addition, the role of myelination in different cognitive processes has begun to be recognized, as well as in the etiology of various mental disorders. Due to its importance, it is necessary to increase basic knowledge to achieve its control, and to be able to promote myelination in cases of interest. In the Cellular Neurophysiology laboratory of the Institute of Neurobiology, we study aspects of the dialogue that neurons establish with oligodendrocytes, and we are interested in knowing the signaling systems that initiate, promote, and maintain their intercommunication. For this, we use the most advanced techniques and concepts of electrophysiology, molecular and cellular biology, and morphological sciences. We think that the moment when an oligodendrocyte establishes contact with the axon, and the myelination program is turned on, is a critical event in the establishment of their relationship. Due to this, we have focused on the study of its properties in this particular time window, promoting its encounter under controlled experimental conditions (both in vitro and in situ). Knowledge about the communication processes that occur during this vital encounter will be useful in understanding and controlling the subsequent phenomenon of myelination. We believe that it will provide useful information in the design of new treatments against demyelinating diseases, and will expand our understanding of its role in brain functions.

Most Recent Publications

1. Cisneros-Mejorado AB, Ordaz RP, Garay E & Arellano R.O., β-carbolines that enhance GABAA receptor response expressed in oligodendrocytes promote remyelination in an in vivo rat model of focal demyelination, Frontiers in Cellular Neuroscience, March 2024; 17

2. Rodríguez-Arzate CA, Noguez-Imm R, Reyes-Ortega P, Rodríguez-Ortiz LR, García-Peña MF, Ordaz RP, Vélez-Uriza F, Cisneros-Mejorado A, Arellano R.O., Pérez CI, Hernández-Zimbrón LF, Dégardin J, Simonutti M, Picaud S and Thébault SC. , Potential contributions of the intrinsic retinal oscillations recording using non-invasive electroretinogram to bioelectronics. , Frontiers in Cellular Neuroscience, February 2024; 17, 1224558

3. Gutiérrez B.A., González-Coronel J.M., Arellano R.O.* and Limon A. , Transcriptional and bioinformatic analysis of GABAA receptors expressed in oligodendrocyte progenitor cells from the human brain, Frontiers in Molecular Neuroscience, October 2023; 16, 1279232

4. Pérez-Samartín A, Garay E, Moctezuma JP, Cisneros-Mejorado A, Sánchez-Gómez MV, Martel-Gallegos G, Robles-Martínez L, Canedo-Antelo M, Matute C, Arellano RO., Inwardly Rectifying K+ Currents in Cultured Oligodendrocytes from Rat Optic Nerve are Insensitive to pH., Neurochemical Research, September 2017

5. Robles-Martínez L, Garay E, Martel-Gallegos MG, Cisneros-Mejorado A, Pérez-Montiel D, Lara A, Arellano RO., KCa3.1 Activation Via P2Y2 Purinergic Receptors Promotes Human Ovarian Cancer Cell (SKOV-3) Migration., Scientific Reports, June 2017; 7(1), 4340

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Publicaciones

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1. Cisneros-Mejorado AB, Ordaz RP, Garay E & Arellano R.O., β-carbolines that enhance GABAA receptor response expressed in oligodendrocytes promote remyelination in an in vivo rat model of focal demyelination, Frontiers in Cellular Neuroscience, March 2024; 17

2. Rodríguez-Arzate CA, Noguez-Imm R, Reyes-Ortega P, Rodríguez-Ortiz LR, García-Peña MF, Ordaz RP, Vélez-Uriza F, Cisneros-Mejorado A, Arellano R.O., Pérez CI, Hernández-Zimbrón LF, Dégardin J, Simonutti M, Picaud S and Thébault SC. , Potential contributions of the intrinsic retinal oscillations recording using non-invasive electroretinogram to bioelectronics. , Frontiers in Cellular Neuroscience, February 2024; 17, 1224558

3. Gutiérrez B.A., González-Coronel J.M., Arellano R.O.* and Limon A. , Transcriptional and bioinformatic analysis of GABAA receptors expressed in oligodendrocyte progenitor cells from the human brain, Frontiers in Molecular Neuroscience, October 2023; 16, 1279232

4. Pérez-Samartín A, Garay E, Moctezuma JP, Cisneros-Mejorado A, Sánchez-Gómez MV, Martel-Gallegos G, Robles-Martínez L, Canedo-Antelo M, Matute C, Arellano RO., Inwardly Rectifying K+ Currents in Cultured Oligodendrocytes from Rat Optic Nerve are Insensitive to pH., Neurochemical Research, September 2017

5. Robles-Martínez L, Garay E, Martel-Gallegos MG, Cisneros-Mejorado A, Pérez-Montiel D, Lara A, Arellano RO., KCa3.1 Activation Via P2Y2 Purinergic Receptors Promotes Human Ovarian Cancer Cell (SKOV-3) Migration., Scientific Reports, June 2017; 7(1), 4340

6. Fattorini G, Melone M, Sánchez-Gómez MV, Arellano RO, Bassi S, Matute C, Conti F., GAT-1 mediated GABA uptake in rat oligodendrocytes., Glia, March 2017; 65(3), 514-522

7. M De la Fuente I, Malaina I, Pérez-Samartín A, Boyano MD, Pérez-Yarza G, Bringas C, Villarroel Á, Fedetz M, Arellano RO, Cortes JM, Martínez L., Dynamic properties of calcium-activated chloride currents in Xenopus laevis oocytes., Scientific Reports, February 2017; 7, 41791

8. Arellano RO, Sanchez-Gomez MV, Alberdi E, Canedo-Antelo M, Chara JC, Palomino A, Perez-Samartin A, Matute C., Axon-to-Glia Interaction Regulates GabaA Receptor Expression in Oligodendrocytes, Molecular Pharmacology, December 2016; 89, 63

9. Antònia Colom‑Casasnovas, Edith Garay, Abraham Cisneros‑Mejorado, Manuel B.Aguilar, Fernando Lazcano‑Pérez, Rogelio O. Arellano* & Judith Sánchez‑Rodríguez, Sea anemone Bartholomea annulata venom inhibits voltage‑gated Na+ channels and activates GABAA receptors from mammals, Scientific Reports, November 2022; 12(5352)

10. Daniel Reyes-Haro, Abraham Cisneros-Mejorado and Rogelio O. Arellano, Therapeutic Potential of GABAergic Signaling in Myelin Plasticity and Repair, Frontiers in Cell and Developmental Biology, April 2021; 9, 1-8

11. Ordaz RP, Garay E, Limon A, Pérez-Samartín A, Sánchez-Gómez MV, Robles-Martínez L, Cisneros-Mejorado A, Matute C, Arellano RO., GABAA Receptors Expressed in Oligodendrocytes Cultured From the Neonatal Rat Contain α3 and γ1 Subunits and Present Differential Functional and Pharmacological Properties. , Molecular Pharmacology, February 2021; 99, 133-146

12. Serrano-Regal MP, Bayón-Cordero L, Ordaz RP, Garay E, Limon A, Arellano RO, Matute C, Sánchez-Gómez MV., Expression and Function of GABA Receptors in Myelinating Cells. , Frontiers in Cellular Neuroscience, August 2020; 14, 256

13. Abraham J.Cisneros-Mejorado, Edith Garay, Juan Ortiz-Retana, Luis Concha, Juan P. Moctezuma, Samuel Romero, Rogelio O.Arellano., Demyelination–Remyelination of the Rat Caudal Cerebellar Peduncle Evaluated with Magnetic Resonance Imaging., Neuroscience, July 2020; 439(jul 15), 439:255-267

14. Cisneros-Mejorado AJ, Pérez-Samartín A, Domercq M, Arellano RO, Gottlieb M, Koch-Nolte F, Matute C., P2X7 Receptors as a Therapeutic Target in Cerebrovascular Diseases., Frontiers in Molecular Neuroscience, June 2020; 13, 92

15. Robles-Martínez L., Garay E., Martel-Gallegos M.G., Lara A., Pérez-Montiel D., and Arellano R.O., KCa3.1 ACTIVATION VIA P2Y2 PURINERGIC RECEPTORS PROMOTES HUMAN OVARIAN CANCER CELL (SKOV-3) MIGRATION, Scientific Reports, December 2017

16. Lazcano-Pérez F, Arellano RO, Garay E, Arreguín-Espinosa R, Sánchez-Rodríguez J., Electrophysiological activity of a neurotoxic fraction from the venom of box jellyfish Carybdea marsupialis. , Comparative Biochemistry And Physiology C-Toxicology & Pharmacology, January 2017; 191, 177-182

17. Barbara Serrano-Flores, Edith Garay, Francisco G. Vázquez-Cuevas, Rogelio O. Arellano. , Differential role of STIM1 and STIM2 during transient inward (Tin) current generation and the maturation process in the Xenopus oocyte, BMC Physiology, November 2014; 14(1), 9

18. Vázquez-Cuevas FG, Martínez-Ramírez AS, Robles-Martínez L, Garay E, García-Carrancá A, Pérez-Montiel D, Castañeda-García C, Arellano RO. , Paracrine stimulation of P2X7 receptor by ATP activates a proliferative pathway in ovarian carcinoma cells., J Cell Biochem, November 2014; 115(11), 1955-66

19. Gonzalez-Fernandez E, Sanchez-Gomez MV, Perez-Samartın A, Arellano RO, and Matute C, A3 Adenosine Receptors Mediate Oligodendrocyte Death and Ischemic Damage to Optic Nerve, Glia, February 2014; 62(2), 199-216

20. Vázquez-Cuevas FG, Cruz-Rico A, Garay E, García-Carrancá A, Pérez-Montiel D, Juárez B, Arellano RO., Differential expression of the P2X7 receptor in ovarian surface epithelium during the oestrous cycle in the mouse., Reproduction, Fertility And Development, December 2013; 25(7), 971-984

21. Ochoa-de la Paz LD, Espino-Saldaña AE, Arellano-Ostoa R, Reyes JP, Miledi R, Martinez-Torres A., Characterization of an outward rectifying chloride current of Xenopus tropicalis oocytes., Biochem. Biophysical Acta, August 2013; 1828(8), 1743-1753

22. Rangel-Yescas GE, Vazquez-Cuevas FG, Garay E, Arellano RO., Cloning and functional analysis of P2X1b, a new variant in rat optic nerve that regulates the P2X1 receptor in a use-dependent manner., Acta Neurobiologiae Experimentalis, December 2012; 72(1), 18-32

23. Arellano RO, Robles L, Serrano BP, Vázquez-Cuevas FG, and Garay, E. , Agonist-activated Ca2+ influx and Ca2+-dependent Cl- channels in Xenopus ovarian follicular cells: functional heterogeneity within the cell monolayer., Journal Of Cellular Physiology, October 2012; 227, 3457-3470

24. Bernaldez J, López O, Licea A, Salceda E, Arellano RO, Vega R, Soto E., Electrophysiological Characterization of a Novel Small Peptide from the Venom of Conus californicus that Targets Voltage-gated Neuronal Ca(2+) Channels., Toxicon, January 2011; 57(1), 60-67

25. Vázquez-Cuevas FG, Zárate-Díaz EP, Garay E, Arellano RO. , Functional expression and intracellular signaling of UTP-sensitive P2Y receptors in theca-interstitial cells. Reprod Biol Endocrinol. 2010 Jul 14;8:88., Reproductive Biology And Endocrinology, July 2010; 8(1), 88-98

26. Hernández-Enríquez B, Arellano RO, Morán J., Role for ionic fluxes on cell death and apoptotic volume decrease in cultured cerebellar granule neurons., Neuroscience, May 2010; 167(2), 298-311

27. Arellano, R.O., E. Garay, F. Vazquez-Cuevas, FUNCTIONAL INTERACTION BETWEEN NATIVE G PROTEIN-COUPLED PURINERGIC RECEPTORS IN XENOPUS FOLLICLES, Proceedings Of The National Academy Of Sciences Of The United States Of America, September 2009; 106(39), 16680-16685

28. Saldaña C., Garay E., Rangel E., Reyes J.L., & R.O. Arellano., NATIVE ION CURRENT COUPLED TO PURINERGIC ACTIVATION VIA BASAL AND MECHANICALLY INDUCED ATP RELEASE IN XENOPUS FOLLICLES., Journal Of Cellular Physiology, January 2009; 218(2), 355-365

29. Mauricio Diaz Muñoz, Patricia de la Rosa Santander, Anna Berenice Juarez Espinoza, Rogelio Arellano Ostoa and Veronica Morales Tlalpan, Granulosa cells express three inositol 1,4,5- trisphosphate receptor isoforms: cytoplasmic and nuclear Ca2+ mobilization., Reproductive Biology And Endocrinology, January 2008; 6(60), 0-0

30. Rangel Yescas Edith, Edith Garay, Rogelio O. Arellano, EL ATP COMO TRANSMISOR QUIMICO EXTRACELULAR., Revista Mexicana De Neurociencias, January 2007; 8(3), 276-285

31. Vázquez-Cuevas F., Juárez B., Garay E., Arellano RO., ATP-Induced apoptotic cell death in porcine ovarian theca cells through P2X7 receptor activation., Molecular Reproduction And Development, January 2006; 73(0), 745-755

32. Saldaña C., Vázquez-Cuevas F., Garay E., Arellano RO., Epithelium and/or theca are required for ATP-elicited K+ current in follicle-enclosed Xenopus oocytes., Journal Of Cellular Physiology, June 2005; 202(3), 814-821

33. Morales-Tlalpan V., Arellano R., Díaz-Muñoz M., Interplay between ryanodine and IP3 receptors in ATP-stimulated mouse luteinized-granulosa cells., Cellular Calcium, January 2005; 37(0), 203-213

34. Tapia V.V., Arellano R., Mas J., ARP2 A NOVEL PROTEIN INVOLVED IN APOPTOSIS OF LNCAP CELLS SHARES A HIGH DEGREE HOMOLOGY WITH SPLICING FACTOR PRP8., Molecular And Cellular Biochemistry, January 2005; 269(0), 189-201

35. Arellano R., Martínez-Torres A., Garay E., Ionic currents activated via purinergic receptors in the cumulus cell-enclosed mouse oocyte., Biology Of Reproduction, January 2002; 67(0), 837-846

36. Torres, M.R., Aguilar, M.B., Falcón, A., Sánchez, L., Radwan, F.F.Y., Burnett, J. W., Heimer de la Cotera, E., Arellano-O., R., "Electrophysiological and hemolytic activity elicited by the venom of the jellyfish Cassiopea xamachana", Toxicon, November 2001; 39(0), 1297-1307

37. Li P., Gao X.-G., Arellano R., V. Renugopalakrishnan., GLYCOSYLATED AND PHOSPHORYLATED PROTEINS -EXPRESSION IN YEAST AND OOCYTES OF XENOPUS: PROSPECTS AND CHALLENGES RELEVANCE TO EXPRESSION OF THERMOSTABLE PROTEINS., Protein Expression And Purification, January 2001; 22(0), 369-380

38. Pérez-Samartín A. L., Miledi R., Arellano R., ACTIVATION OF VOLUME-REGULATED CL(-) CHANNELS BY ACH AND ATP IN XENOPUS FOLLICLES., Journal Of Physiology-London, January 2000; 525.3(0), 721-734

39. Arellano R., Garay E., Miledi R., Muscarinic receptor heterogeneity in follicle-enclosed Xenopus oocytes., Journal Of Physiology-London, January 1999; 521(0), 409-419

40. Arellano R., Garay E., Miledi R., CL-currents activated via purinergic receptors in Xrnopus follicles , American Journal Of Physiology-Cell Physiology, January 1998; 43(0), C333-C340

41. Arellano R., Miledi R., FUNCTIONAL ROLE OF FOLLICULAR CELLS IN THE GENERATION OF OSMOLARITY-DEPENDENT CL- CURRENTS IN XENOPUS FOLLICLES., Journal Of Physiology-London, January 1995; 488.2(0), 351-357

42. Arellano R., Woodward R.M., Miledi R., A MONOVALENT CATIONIC CONDUCTANCE THAT IS BLOCKED BY EXTRACELLULAR DIVALENT CATIONS IN XENOPUS OOCYTES., Journal Of Physiology-London, January 1995; 484.3(0), 593-604

43. ARELLANO, R. O., AND MILEDI, R., OSMODEPENDENT CL CURRENTS ACTIVATED BY CYCLIC AMP INFOLLICLE ENCLOSED XENOPUS OOCYTES., Proceedings Of The Royal Society B, January 1994; 258(0), 229-235

44. ARELLANO, R. O., AND MILEDI, R., NOVEL CL CURRENTS ELICITED BY FOLLICLE STIMULATING HORMONE AND ACETYLCHOLINE IN FOLLICLEENCLOSED XENOPUS OOCYTES., Journal Of General Physiology, January 1993; 102(0), 833-857

45. MATUTE, C., ARELLANO, R. O., CONDEGUERRI, B., AND MILEDI, R., MRNA CODING FOR NEUROTRANSMITTER RECEPTORS IN A HUMAN ASTROCYTOMA., Proceedings Of The National Academy Of Sciences Of The United States Of America, January 1992; 89(0), 3399-3403

46. Moreno, A. P., R. O. Arellano, A. Rivera & F. Ramon, HUMORAL FACTORS REDUCE GAP JUNCTION SENSITIVITY TO CYTOPLASMIC PH. II. IN VITRO MANIPULATIONS., American Journal Of Physiology, January 1991; 260(260), C1039-C1045

47. Arellano, R.O., A. Rivera & F. Ramon, PROTEIN PHOSPHORYLATION AND HYDROGEN IONS MODULATE CALCIUM-INDUCED CLOSURE OF GAP JUNCTION CHANNELS., Biophysical Journal, January 1990; 57(57), 363-367

48. Arellano, R.O., F. Ramon, A. Rivera & G.A. Zampighi, CALMODULIN ACTS AS AN INTERMEDIARY FOR THE EFFECTS OF CALCIUM ON GAP JUNCTIONS FROM CRAYFISH LATERAL AXONS., Journal Of Membrane Biology, January 1988; 101(101), 119-131

49. Ramon, F., R. O. Arellano, A. Rivera & G.A. Zampighi, EFFECTS OF INTERNALLY PERFUSED CALMODULIN ON THE JUNCTIONAL RESISTANCE OF CRAYFISH LATERAL AXONS. IN: GAP JUNCTIONS. MODERN CELL BIOLOGY VOLUME 7 (E.L. HERTZBERG AND R.G. JOHNSON, EDS.). ALAN R., Modern Cell Biology, January 1988; 7(Volume 7), 255-265

50. Arellano, R.O., F. Ramon, A. Rivera & G.A. Zampighi, LOWERING OF PH DOES NOT DIRECTLY AFFECT THE JUNCTIONAL RESISTANCE OF CRAYFISH LATERAL AXONS., Journal Of Membrane Biology, January 1986; 94(94), 293-299

Most Recent Advised Theses

1. Cindy Lucero García García (estudiante), MECANISMOS MOLECULARES DEL INFLUJO DE CA2+, ACTIVADO POR NEUROTRANSMISORES EN EL LINAJE OLIGODENDROGLIAL , Modalidad: Tesis, Maestría en Ciencias (Neurobiología), Maestría, Instituto de Neurobiología UNAM-Juriquilla, Instituto de Neurobiología UNAM-Juriquilla, Fecha de presentación de examen: 2023-08-14, Arellano Ostoa Rogelio (Director)

2. María Berenice Varela Correa (estudiante), Expresión del Receptor Oligodendroglial en células HEK293., Modalidad: Tesis, Maestría en Ciencias (Neurobiología), Maestría, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Fecha de presentación de examen: 2022-09-23, Arellano Ostoa Rogelio (Director)

3. BERENICE ADRIANA GUTIÉRREZ GREBENKOVA (estudiante), EXPRESIÓN DEL RECEPTOR GABAA OLIGONDENDROGLIAL EN EL CEREBRO HUMANO, Modalidad: Informe académico, Programa Nacional de Servicio Social en Investigación en Salud, Licenciatura, Escuela de Medicina, Instituto Tecnológico de Monterrey, Fecha de presentación de examen: 2022-01-31, Arellano Ostoa Rogelio (Director)

4. Rainald Pablo Ordaz (estudiante), Identidad del receptor GABAA oligodendroglial, Modalidad: Candidatura a grado de doctor, PDCB, Doctorado, INB UNAM, Instituto de Neurobiología UNAM-Juriquilla, Fecha de presentación de examen: 2019-09-25, Arellano Ostoa Rogelio (Director)

5. Juan Pablo Moctezuma Hernández (estudiante), Insensibilidad a H+ de los canales tipo Kir en oligodendrocitos del nervio óptico de la rata, Modalidad: Por proyecto de investigación, Maestría en Ciencias (Neurobiología), Maestría, Instituto de Neurobiología UNAM-Juriquilla, INB-UNAM, Instituto de Neurobiología UNAM-Juriquilla, Fecha de presentación de examen: 2017-10-06, Arellano Ostoa Rogelio (Director)

Most Recent Chapters in Books

1. ROGELIO O. ARELLANO, RICHARD M. WOODWARD, RICARDO MILEDI, ION CHANNELS, 1a, , Estados Unidos de América, 1996

2. RAMON, F., ARELLANO, R. O., AND RIVERA, A., BIOPHYSICS OF GAP JUNCTION CHANNELS, 1a, , Estados Unidos de América, 1991

3. RAMON, F., ARELLANO, R. O., RIVERA, A., AND ZAMPIGUI, G. A., GAP JUNCTIONS, MODERN CELL BIOLOGY, 1a, , Estados Unidos de América, 1988